Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics (Review)

  • Authors:
    • Ioannis S. Vizirianakis
    • George A. Mystridis
    • Konstantinos Avgoustakis
    • Dimitrios G. Fatouros
    • Marios Spanakis
  • View Affiliations

  • Published online on: January 18, 2016     https://doi.org/10.3892/or.2016.4575
  • Pages: 1891-1904
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Abstract

The existing tumor heterogeneity and the complexity of cancer cell biology critically demand powerful translational tools with which to support interdisciplinary efforts aiming to advance personalized cancer medicine decisions in drug development and clinical practice. The development of physiologically based pharmacokinetic (PBPK) models to predict the effects of drugs in the body facilitates the clinical translation of genomic knowledge and the implementation of in vivo pharmacology experience with pharmacogenomics. Such a direction unequivocally empowers our capacity to also make personalized drug dosage scheme decisions for drugs, including molecularly targeted agents and innovative nanoformulations, i.e. in establishing pharmacotyping in prescription. In this way, the applicability of PBPK models to guide individualized cancer therapeutic decisions of broad clinical utility in nanomedicine in real-time and in a cost-affordable manner will be discussed. The latter will be presented by emphasizing the need for combined efforts within the scientific borderlines of genomics with nanotechnology to ensure major benefits and productivity for nanomedicine and personalized medicine interventions.
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April-2016
Volume 35 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Vizirianakis IS, Mystridis GA, Avgoustakis K, Fatouros DG and Spanakis M: Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics (Review). Oncol Rep 35: 1891-1904, 2016
APA
Vizirianakis, I.S., Mystridis, G.A., Avgoustakis, K., Fatouros, D.G., & Spanakis, M. (2016). Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics (Review). Oncology Reports, 35, 1891-1904. https://doi.org/10.3892/or.2016.4575
MLA
Vizirianakis, I. S., Mystridis, G. A., Avgoustakis, K., Fatouros, D. G., Spanakis, M."Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics (Review)". Oncology Reports 35.4 (2016): 1891-1904.
Chicago
Vizirianakis, I. S., Mystridis, G. A., Avgoustakis, K., Fatouros, D. G., Spanakis, M."Enabling personalized cancer medicine decisions: The challenging pharmacological approach of PBPK models for nanomedicine and pharmacogenomics (Review)". Oncology Reports 35, no. 4 (2016): 1891-1904. https://doi.org/10.3892/or.2016.4575