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Article

Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma

  • Authors:
    • M. Brisam
    • S. Rauthe
    • S. Hartmann
    • C. Linz
    • R. C. Brands
    • A. C. Kübler
    • A. Rosenwald
    • U. D. Müller-Richter
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Plastic Surgery, University Hospital Würzburg, D-97070 Würzburg, Germany, Institute of Pathology, University Würzburg, D-97080 Würzburg, Germany
  • Pages: 1979-1986
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    Published online on: January 28, 2016
       https://doi.org/10.3892/or.2016.4600
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Abstract

MAGE-A proteins are highly expressed in oral squamous cell carcinoma (OSCC) and are promising targets for cancer immunotherapy. This study examined the presence of MAGE-A expression within the tumor center (TC) and tumor invasive front (TIF) and evaluated its relationship to poor prognosis. The expression rate of each MAGE-A subtype, A1-A12, was examined in 68 OSCCs at the TIF and TC. Slides (1-µm) of tissue microarrays (diameter =0.6 mm) were immunohistochemically stained, and the findings were correlated to clinical data. Approximately 95% of the tumors had MAGE-A expression. Higher expression in the TC was shown significantly for MAGE-A1, -A5, -A6, -A9 and -A12 (P<0.05). MAGE-A2 and -A3 exhibited the opposite behavior (not significant, P>0.05). Age, tumor size, grade and survival time were not associated with the expression of certain MAGE-A subgroups. When expression in the whole tumor tissue was considered, only MAGE-A1 was expressed at a significantly higher rate in male patients (P=0.034). At the TIF, MAGE-A9 and the UICC disease stage were significantly correlated (P=0.0263), and MAGE-A6 and the UICC disease stage exhibited a strong trend (P=0.0596). The expression of MAGE-A3, -A4, -A5, -A9 and -A11 was significantly associated with lymph node metastasis, while MAGE-A4 was expressed in all regions of the tumors (TIF and TC). This study showed that higher expression of most MAGE-A antigens occurred at the TC rather than at the TIF. MAGE‑A1, -A3, -A4, -A5, -A9 and -A11 were significantly associated with clinically advanced stages of disease and seem to be of particular interest.
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Copy and paste a formatted citation
Spandidos Publications style
Brisam M, Rauthe S, Hartmann S, Linz C, Brands RC, Kübler AC, Rosenwald A and Müller-Richter UD: Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma. Oncol Rep 35: 1979-1986, 2016.
APA
Brisam, M., Rauthe, S., Hartmann, S., Linz, C., Brands, R.C., Kübler, A.C. ... Müller-Richter, U.D. (2016). Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma. Oncology Reports, 35, 1979-1986. https://doi.org/10.3892/or.2016.4600
MLA
Brisam, M., Rauthe, S., Hartmann, S., Linz, C., Brands, R. C., Kübler, A. C., Rosenwald, A., Müller-Richter, U. D."Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma". Oncology Reports 35.4 (2016): 1979-1986.
Chicago
Brisam, M., Rauthe, S., Hartmann, S., Linz, C., Brands, R. C., Kübler, A. C., Rosenwald, A., Müller-Richter, U. D."Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma". Oncology Reports 35, no. 4 (2016): 1979-1986. https://doi.org/10.3892/or.2016.4600
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Spandidos Publications style
Brisam M, Rauthe S, Hartmann S, Linz C, Brands RC, Kübler AC, Rosenwald A and Müller-Richter UD: Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma. Oncol Rep 35: 1979-1986, 2016.
APA
Brisam, M., Rauthe, S., Hartmann, S., Linz, C., Brands, R.C., Kübler, A.C. ... Müller-Richter, U.D. (2016). Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma. Oncology Reports, 35, 1979-1986. https://doi.org/10.3892/or.2016.4600
MLA
Brisam, M., Rauthe, S., Hartmann, S., Linz, C., Brands, R. C., Kübler, A. C., Rosenwald, A., Müller-Richter, U. D."Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma". Oncology Reports 35.4 (2016): 1979-1986.
Chicago
Brisam, M., Rauthe, S., Hartmann, S., Linz, C., Brands, R. C., Kübler, A. C., Rosenwald, A., Müller-Richter, U. D."Expression of MAGE-A1-A12 subgroups in the invasive tumor front and tumor center in oral squamous cell carcinoma". Oncology Reports 35, no. 4 (2016): 1979-1986. https://doi.org/10.3892/or.2016.4600
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