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Article

Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma

  • Authors:
    • Kai Jiang
    • Wei Li
    • Shuxin Shang
    • Lu Sun
    • Kun Guo
    • Shu Zhang
    • Yinkun Liu
  • View Affiliations / Copyright

    Affiliations: Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, P.R. China, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China, Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
  • Pages: 2141-2150
    |
    Published online on: January 28, 2016
       https://doi.org/10.3892/or.2016.4601
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Abstract

Golgi protein 73 (GP73), a resident Golgi type-II membrane protein, is often upregulated in hepatocytes. In the present study, shRNA-mediated suppression of GP73 expression in hepatocellular carcinoma (HCC) cell lines (MHCC97H, HCCLM3) resulted in a significant inhibition of cell motility and invasion and also led to the regression of epithelial-mesenchymal transition phenotypes. In contrast, overexpression of GP73 in the SMMC7721 cell line retrieved the expression of EMT markers, and promoted cell motility and invasion. High expression of GP73 was also found in HCC tissues with metastasis, as detected by western blot and immunohistochemistry analyses. Kaplan-Meier survival analysis showed that the survival of patients with high GP73 expression was significantly poorer than that of patients with low GP73 expression (p=0.027). Our findings demonstrated an important role of GP73 in HCC metastasis, and indicated that GP73 is a candidate target for HCC therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang K, Li W, Shang S, Sun L, Guo K, Zhang S and Liu Y: Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma. Oncol Rep 35: 2141-2150, 2016.
APA
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., & Liu, Y. (2016). Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma. Oncology Reports, 35, 2141-2150. https://doi.org/10.3892/or.2016.4601
MLA
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., Liu, Y."Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma". Oncology Reports 35.4 (2016): 2141-2150.
Chicago
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., Liu, Y."Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma". Oncology Reports 35, no. 4 (2016): 2141-2150. https://doi.org/10.3892/or.2016.4601
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang K, Li W, Shang S, Sun L, Guo K, Zhang S and Liu Y: Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma. Oncol Rep 35: 2141-2150, 2016.
APA
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., & Liu, Y. (2016). Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma. Oncology Reports, 35, 2141-2150. https://doi.org/10.3892/or.2016.4601
MLA
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., Liu, Y."Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma". Oncology Reports 35.4 (2016): 2141-2150.
Chicago
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., Liu, Y."Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma". Oncology Reports 35, no. 4 (2016): 2141-2150. https://doi.org/10.3892/or.2016.4601
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