Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma

  • Authors:
    • Kai Jiang
    • Wei Li
    • Shuxin Shang
    • Lu Sun
    • Kun Guo
    • Shu Zhang
    • Yinkun Liu
  • View Affiliations

  • Published online on: January 28, 2016     https://doi.org/10.3892/or.2016.4601
  • Pages: 2141-2150
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Abstract

Golgi protein 73 (GP73), a resident Golgi type-II membrane protein, is often upregulated in hepatocytes. In the present study, shRNA-mediated suppression of GP73 expression in hepatocellular carcinoma (HCC) cell lines (MHCC97H, HCCLM3) resulted in a significant inhibition of cell motility and invasion and also led to the regression of epithelial-mesenchymal transition phenotypes. In contrast, overexpression of GP73 in the SMMC7721 cell line retrieved the expression of EMT markers, and promoted cell motility and invasion. High expression of GP73 was also found in HCC tissues with metastasis, as detected by western blot and immunohistochemistry analyses. Kaplan-Meier survival analysis showed that the survival of patients with high GP73 expression was significantly poorer than that of patients with low GP73 expression (p=0.027). Our findings demonstrated an important role of GP73 in HCC metastasis, and indicated that GP73 is a candidate target for HCC therapy.
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April-2016
Volume 35 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Jiang K, Li W, Shang S, Sun L, Guo K, Zhang S and Liu Y: Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma. Oncol Rep 35: 2141-2150, 2016
APA
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., & Liu, Y. (2016). Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma. Oncology Reports, 35, 2141-2150. https://doi.org/10.3892/or.2016.4601
MLA
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., Liu, Y."Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma". Oncology Reports 35.4 (2016): 2141-2150.
Chicago
Jiang, K., Li, W., Shang, S., Sun, L., Guo, K., Zhang, S., Liu, Y."Aberrant expression of Golgi protein 73 is indicative of a poor outcome in hepatocellular carcinoma". Oncology Reports 35, no. 4 (2016): 2141-2150. https://doi.org/10.3892/or.2016.4601