miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression

  • Authors:
    • Feng Xiong
    • Keyun Liu
    • Fumei Zhang
    • Kaihui Sha
    • Xinyuan Wang
    • Xiaojuan Guo
    • Ning Huang
  • View Affiliations

  • Published online on: February 16, 2016     https://doi.org/10.3892/or.2016.4624
  • Pages: 3000-3008
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Abstract

While miR-204 expression may be linked to renal cell carcinoma (RCC) progression, the detailed mechanisms remain unclear. In the present study, we demonstrated that miR-204 was differentially expressed in RCC tissues when compared with surrounding normal kidney tissues. Ectopic overexpression of miR-204 in human RCC cells suppressed cell proliferation and invasion in vitro and in vivo. Mechanism dissection revealed that miR-204 may function through RAB22A signals to inhibit RCC proliferation and invasion. Overexpression of RAB22A by oe-RAB22A was able to partially reverse the miR-204-mediated suppression of RCC tumor progression. Together, these results revealed that miR-204 suppressed RCC proliferation and invasion by directly targeting the RAB22A gene. Targeting newly identified RAB22A with miR-204 may aid in the suppression of RCC proliferation and invasion.
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May-2016
Volume 35 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Xiong F, Liu K, Zhang F, Sha K, Wang X, Guo X and Huang N: miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression. Oncol Rep 35: 3000-3008, 2016
APA
Xiong, F., Liu, K., Zhang, F., Sha, K., Wang, X., Guo, X., & Huang, N. (2016). miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression. Oncology Reports, 35, 3000-3008. https://doi.org/10.3892/or.2016.4624
MLA
Xiong, F., Liu, K., Zhang, F., Sha, K., Wang, X., Guo, X., Huang, N."miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression". Oncology Reports 35.5 (2016): 3000-3008.
Chicago
Xiong, F., Liu, K., Zhang, F., Sha, K., Wang, X., Guo, X., Huang, N."miR-204 inhibits the proliferation and invasion of renal cell carcinoma by inhibiting RAB22A expression". Oncology Reports 35, no. 5 (2016): 3000-3008. https://doi.org/10.3892/or.2016.4624