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Article

miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1

  • Authors:
    • Wenlong Cao
    • Weiyuan Wei
    • Zexu Zhan
    • Yubo Xie
    • Qiang Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Anaesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
  • Pages: 2583-2591
    |
    Published online on: February 29, 2016
       https://doi.org/10.3892/or.2016.4643
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Abstract

Routine chemotherapy as an important treatment mode often can not be effective because of multidrug resistance (MDR). MicroRNA (miRNA) modulates the expression of a great number of genes, including MDR. In this study, the expression of miR-1284 was reduced in gastric cancer (GC) tissue specimens with metastasis and in vincristine-resistant (VCR) GC SGC7901 cells (SGC-7901/VCR) compared to that in the controls. Recombinant lentiviral vectors with miR-1284 led to the overexpression of miR-1284 mRNA and reversed the chemoresistance of SGC7901/VCR cells, promoted cell cycle arrested at the G0/G1 phase, accelerated drug-induced apoptosis, and decreased migration and invasiveness of SGC-7901/VCR. In addition, the overexpression of miR-1284 sensitized tumors to chemotherapy in vivo. Our data provide combined evidence that miR-1284 can heighten the expression of MYC and reduce the expression of JUN, MMP12, and EIF4A1 that was the direct target. In conclusion, miR-1284 can function as a new regulator to reduce GC MDR cells by targeting EIF4A1.
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Copy and paste a formatted citation
Spandidos Publications style
Cao W, Wei W, Zhan Z, Xie Y and Xiao Q: miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1. Oncol Rep 35: 2583-2591, 2016.
APA
Cao, W., Wei, W., Zhan, Z., Xie, Y., & Xiao, Q. (2016). miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1. Oncology Reports, 35, 2583-2591. https://doi.org/10.3892/or.2016.4643
MLA
Cao, W., Wei, W., Zhan, Z., Xie, Y., Xiao, Q."miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1". Oncology Reports 35.5 (2016): 2583-2591.
Chicago
Cao, W., Wei, W., Zhan, Z., Xie, Y., Xiao, Q."miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1". Oncology Reports 35, no. 5 (2016): 2583-2591. https://doi.org/10.3892/or.2016.4643
Copy and paste a formatted citation
x
Spandidos Publications style
Cao W, Wei W, Zhan Z, Xie Y and Xiao Q: miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1. Oncol Rep 35: 2583-2591, 2016.
APA
Cao, W., Wei, W., Zhan, Z., Xie, Y., & Xiao, Q. (2016). miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1. Oncology Reports, 35, 2583-2591. https://doi.org/10.3892/or.2016.4643
MLA
Cao, W., Wei, W., Zhan, Z., Xie, Y., Xiao, Q."miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1". Oncology Reports 35.5 (2016): 2583-2591.
Chicago
Cao, W., Wei, W., Zhan, Z., Xie, Y., Xiao, Q."miR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1". Oncology Reports 35, no. 5 (2016): 2583-2591. https://doi.org/10.3892/or.2016.4643
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