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Article

Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells

  • Authors:
    • Lin Li
    • Xian-Zi Wen
    • Zhao-De Bu
    • Xiao-Jing Cheng
    • Xiao-Fang Xing
    • Xiao-Hong Wang
    • Lian-Hai Zhang
    • Ting Guo
    • Hong Du
    • Ying Hu
    • Biao Fan
    • Jia-Fu Ji
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital and Institute, Beijing, P.R. China, Department of Gastrointestinal Surgery, Peking University Cancer Hospital and Institute, Beijing, P.R. China, Department of Tissue Bank, Peking University Cancer Hospital and Institute, Beijing, P.R. China
  • Pages: 3009-3017
    |
    Published online on: March 9, 2016
       https://doi.org/10.3892/or.2016.4666
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Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) holds promise for cancer therapy due to its unique capacity to selectively trigger apoptosis in cancer cells. However, TRAIL therapy is greatly hampered by its resistance. A preclinical successful strategy is to identify combination treatments that sensitize resistant cancers to TRAIL. In the present study, we fully assessed TRAIL sensitivity in 9 gastric cancer cell lines. We found combined administration of paclitaxel (PTX) markedly enhanced TRAIL-induced apoptosis in resistant cancer cells both in vitro and in vivo. The sensitization to TRAIL was accompanied by activation of mitochondrial apoptotic pathway, upregulation of TRAIL receptors and downregulation of anti-apoptotic proteins including C-IAP1, C-IAP2, Livin and Mcl-1. Noticeably, we found PTX could suppress the activation of mitogen-activated protein kinases (MAPKs). Inhibition of MAPKs using specific inhibitors (ERK inhibitor U0126, JNK inhibitor SP600125 and P38 inhibitor SB202190) facilitated TRAIL-mediated apoptosis and cytotoxicity. Additionally, SP600125 upregulated TRAL receptors as well as downregulated C-IAP2 and Mcl-1 suggesting the anti-apoptotic role of JNK. Thus, PTX-induced suppression of MAPKs may contribute to restoring TRAIL senstitivity. Collectively, our comprehensive analyses gave new insight into the role of PTX on enhancing TRAIL sensitivity, and provided theoretical references on the development of combination treatment in TRAIL-resistant gastric cancer.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Call JA, Eckhardt SG and Camidge DR: Targeted manipulation of apoptosis in cancer treatment. Lancet Oncol. 9:1002–1011. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Pitti RM, Marsters SA, Ruppert S, Donahue CJ, Moore A and Ashkenazi A: Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J Biol Chem. 271:12687–12690. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Kischkel FC, Lawrence DA, Chuntharapai A, Schow P, Kim KJ and Ashkenazi A: Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity. 12:611–620. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Samraj AK, Keil E, Ueffing N, Schulze-Osthoff K and Schmitz I: Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis. J Biol Chem. 281:29652–29659. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Herbst RS, Eckhardt SG, Kurzrock R, Ebbinghaus S, O'Dwyer PJ, Gordon MS, Novotny W, Goldwasser MA, Tohnya TM, Lum BL, et al: Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. J Clin Oncol. 28:2839–2846. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Soria JC, Smit E, Khayat D, Besse B, Yang X, Hsu CP, Reese D, Wiezorek J and Blackhall F: Phase 1b study of dulanermin (recombinant human Apo2L/TRAIL) in combination with paclitaxel, carboplatin, and bevacizumab in patients with advanced non-squamous non-small-cell lung cancer. J Clin Oncol. 28:1527–1533. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Wiezorek J, Holland P and Graves J: Death receptor agonists as a targeted therapy for cancer. Clin Cancer Res. 16:1701–1708. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Dimberg LY, Anderson CK, Camidge R, Behbakht K, Thorburn A and Ford HL: On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene. 32:1341–1350. 2013. View Article : Google Scholar

10 

Prasad S, Kim JH, Gupta SC and Aggarwal BB: Targeting death receptors for TRAIL by agents designed by Mother Nature. Trends Pharmacol Sci. 35:520–536. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Horak P, Pils D, Haller G, Pribill I, Roessler M, Tomek S, Horvat R, Zeillinger R, Zielinski C and Krainer M: Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer. Mol Cancer Res. 3:335–343. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Bin L, Thorburn J, Thomas LR, Clark PE, Humphreys R and Thorburn A: Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding. J Biol Chem. 282:28189–28194. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Zhang Y and Zhang B: TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5. Mol Cancer Res. 6:1861–1871. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Grotzer MA, Eggert A, Zuzak TJ, Janss AJ, Marwaha S, Wiewrodt BR, Ikegaki N, Brodeur GM and Phillips PC: Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression. Oncogene. 19:4604–4610. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Ricci MS, Kim SH, Ogi K, Plastaras JP, Ling J, Wang W, Jin Z, Liu YY, Dicker DT, Chiao PJ, et al: Reduction of TRAIL-induced Mcl-1 and cIAP2 by c-Myc or sorafenib sensitizes resistant human cancer cells to TRAIL-induced death. Cancer Cell. 12:66–80. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Munshi A, Pappas G, Honda T, McDonnell TJ, Younes A, Li Y and Meyn RE: TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2. Oncogene. 20:3757–3765. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Finlay D, Vamos M, González-López M, Ardecky RJ, Ganji SR, Yuan H, Su Y, Cooley TR, Hauser CT, Welsh K, et al: Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: Roles of XIAP and cIAPs. Mol Cancer Ther. 13:5–15. 2014. View Article : Google Scholar :

18 

Kocab AJ, Veloso A, Paulsen MT, Ljungman M and Duckett CS: Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling. Oncogene. 34:5472–5481. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Mucha SR, Rizzani A, Gerbes AL, Camaj P, Thasler WE, Bruns CJ, Eichhorst ST, Gallmeier E, Kolligs FT, Göke B, et al: JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand. Gut. 58:688–698. 2009. View Article : Google Scholar

20 

Lee HH, Jeong JW, Lee JH, Kim GY, Cheong J, Jeong YK, Yoo YH and Choi YH: Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway. Oncol Rep. 30:1257–1264. 2013.PubMed/NCBI

21 

Liu J, Qu X, Xu L, Zhang Y, Qu J, Hou K and Liu Y: Phosphoinositide 3-kinase/Akt and nuclear factor κB pathways are involved in tumor necrosis factor-related apoptosis-inducing ligand resistance in human gastric cancer cells. Mol Med Rep. 3:491–496. 2010. View Article : Google Scholar

22 

Wan Z, Pan H, Liu S, Zhu J, Qi W, Fu K, Zhao T and Liang J: Downregulation of SNAIL sensitizes hepatocellular carcinoma cells to TRAIL-induced apoptosis by regulating the NF-κB pathway. Oncol Rep. 33:1560–1566. 2015.PubMed/NCBI

23 

Nazim UM, Jeong JK, Seol JW, Hur J, Eo SK, Lee JH and Park SY: Inhibition of the autophagy flux by gingerol enhances TRAIL-induced tumor cell death. Oncol Rep. 33:2331–2336. 2015.PubMed/NCBI

24 

Liu YJ, Lin YC, Lee JC, Kuo SC, Ho CT, Huang LJ, Kuo DH and Way TD: CCT327 enhances TRAIL-induced apoptosis through the induction of death receptors and downregulation of cell survival proteins in TRAIL-resistant human leukemia cells. Oncol Rep. 32:1257–1264. 2014.PubMed/NCBI

25 

Pasquier E, Carré M, Pourroy B, Camoin L, Rebaï O, Briand C and Braguer D: Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway. Mol Cancer Ther. 3:1301–1310. 2004.PubMed/NCBI

26 

Gong J, Yang D, Kohanim S, Humphreys R, Broemeling L and Kurzrock R: Novel in vivo imaging shows up-regulation of death receptors by paclitaxel and correlates with enhanced antitumor effects of receptor agonist antibodies. Mol Cancer Ther. 5:2991–3000. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Hunter TB, Manimala NJ, Luddy KA, Catlin T and Antonia SJ: Paclitaxel and TRAIL synergize to kill paclitaxel-resistant small cell lung cancer cells through a caspase-independent mechanism mediated through AIF. Anticancer Res. 31:3193–3204. 2011.PubMed/NCBI

28 

Nimmanapalli R, Perkins CL, Orlando M, O'Bryan E, Nguyen D and Bhalla KN: Pretreatment with paclitaxel enhances apo-2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of prostate cancer cells by inducing death receptors 4 and 5 protein levels. Cancer Res. 61:759–763. 2001.PubMed/NCBI

29 

Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G and Yaffe MB: Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 149:780–794. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Tsuburaya A, Yoshida K, Kobayashi M, Yoshino S, Takahashi M, Takiguchi N, Tanabe K, Takahashi N, Imamura H, Tatsumoto N, et al: Sequential paclitaxel followed by tegafur and uracil (UFT) or S-1 versus UFT or S-1 monotherapy as adjuvant chemotherapy for T4a/b gastric cancer (SAMIT): A phase 3 factorial randomised controlled trial. Lancet Oncol. 15:886–893. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Trivedi R, Maurya R and Mishra DP: Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway. Cell Death Dis. 5:e14652014. View Article : Google Scholar : PubMed/NCBI

32 

McDaid HM and Horwitz SB: Selective potentiation of paclitaxel (taxol)-induced cell death by mitogen-activated protein kinase kinase inhibition in human cancer cell lines. Mol Pharmacol. 60:290–301. 2001.PubMed/NCBI

33 

von Haefen C, Wieder T, Essmann F, Schulze-Osthoff K, Dörken B and Daniel PT: Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. Oncogene. 22:2236–2247. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Do MT, Na M, Kim HG, Khanal T, Choi JH, Jin SW, Oh SH, Hwang IH, Chung YC, Kim HS, et al: Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways. Food Chem Toxicol. 71:51–59. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Paterson AL, Shannon NB, Lao-Sirieix P, Ong CA, Peters CJ, O'Donovan M and Fitzgerald RC: A systematic approach to therapeutic target selection in oesophago-gastric cancer. Gut. 62:1415–1424. 2013. View Article : Google Scholar

36 

Söderström TS, Poukkula M, Holmström TH, Heiskanen KM and Eriksson JE: Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8. J Immunol. 169:2851–2860. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Mandal R, Raab M, Matthess Y, Becker S, Knecht R and Strebhardt K: pERK 1/2 inhibit caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner. Mol Oncol. 8:232–249. 2014. View Article : Google Scholar

38 

Yerbes R, López-Rivas A, Reginato MJ and Palacios C: Control of FLIP(L) expression and TRAIL resistance by the extracellular signal-regulated kinase1/2 pathway in breast epithelial cells. Cell Death Differ. 19:1908–1916. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Kim EY, Ryu JH and Kim AK: CAPE promotes TRAIL-induced apoptosis through the upregulation of TRAIL receptors via activation of p38 and suppression of JNK in SK-Hep1 hepatocellular carcinoma cells. Int J Oncol. 43:1291–1300. 2013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Wen X, Bu Z, Cheng X, Xing X, Wang X, Zhang L, Guo T, Du H, Hu Y, Hu Y, et al: Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells. Oncol Rep 35: 3009-3017, 2016.
APA
Li, L., Wen, X., Bu, Z., Cheng, X., Xing, X., Wang, X. ... Ji, J. (2016). Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells. Oncology Reports, 35, 3009-3017. https://doi.org/10.3892/or.2016.4666
MLA
Li, L., Wen, X., Bu, Z., Cheng, X., Xing, X., Wang, X., Zhang, L., Guo, T., Du, H., Hu, Y., Fan, B., Ji, J."Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells". Oncology Reports 35.5 (2016): 3009-3017.
Chicago
Li, L., Wen, X., Bu, Z., Cheng, X., Xing, X., Wang, X., Zhang, L., Guo, T., Du, H., Hu, Y., Fan, B., Ji, J."Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells". Oncology Reports 35, no. 5 (2016): 3009-3017. https://doi.org/10.3892/or.2016.4666
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Wen X, Bu Z, Cheng X, Xing X, Wang X, Zhang L, Guo T, Du H, Hu Y, Hu Y, et al: Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells. Oncol Rep 35: 3009-3017, 2016.
APA
Li, L., Wen, X., Bu, Z., Cheng, X., Xing, X., Wang, X. ... Ji, J. (2016). Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells. Oncology Reports, 35, 3009-3017. https://doi.org/10.3892/or.2016.4666
MLA
Li, L., Wen, X., Bu, Z., Cheng, X., Xing, X., Wang, X., Zhang, L., Guo, T., Du, H., Hu, Y., Fan, B., Ji, J."Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells". Oncology Reports 35.5 (2016): 3009-3017.
Chicago
Li, L., Wen, X., Bu, Z., Cheng, X., Xing, X., Wang, X., Zhang, L., Guo, T., Du, H., Hu, Y., Fan, B., Ji, J."Paclitaxel enhances tumoricidal potential of TRAIL via inhibition of MAPK in resistant gastric cancer cells". Oncology Reports 35, no. 5 (2016): 3009-3017. https://doi.org/10.3892/or.2016.4666
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