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Article

Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia

  • Authors:
    • Yuxuan Che
    • Xing Ren
    • Liye Xu
    • Xiaolei Ding
    • Xuan Zhang
    • Xiuhua Sun
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China, College of Stomatology, Dalian Medical University, Dalian, Liaoning 116027, P.R. China
  • Pages: 3025-3033
    |
    Published online on: March 11, 2016
       https://doi.org/10.3892/or.2016.4673
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Abstract

The fucosyltransferases are key enzymes in cell surface antigen synthesis during multidrug resistance (MDR) development. The aim of the present study was to analyze the alteration of α(1,2)-fucosyltransferase involved in MDR development in human chronic myeloid leukemia (CML). FUT1 was overexpressed in three CML/MDR cell lines and peripheral blood mononuclear cells (PBMC) of CML patients. However, no significant changes of FUT2 were observed. The altered levels of FUT1 had a significant impact on the phenotypic variation of MDR of K562 and K562/ADR cells, the activity of EGFR/MAPK pathway and P-glycoprotein (P-gp) expression. Blocking the EGFR/MAPK pathway by its specific inhibitor PD153035 or EGFR small interfering RNA (siRNA) resulted in the reduced MDR of K562/ADR cells. This study indicated that α(1,2)-fucosyltransferase involved in the development of MDR of CML cells probably through FUT1 regulated the activity of EGFR/MAPK signaling pathway and the expression of P-gp.
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Copy and paste a formatted citation
Spandidos Publications style
Che Y, Ren X, Xu L, Ding X, Zhang X and Sun X: Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia. Oncol Rep 35: 3025-3033, 2016.
APA
Che, Y., Ren, X., Xu, L., Ding, X., Zhang, X., & Sun, X. (2016). Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia. Oncology Reports, 35, 3025-3033. https://doi.org/10.3892/or.2016.4673
MLA
Che, Y., Ren, X., Xu, L., Ding, X., Zhang, X., Sun, X."Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia". Oncology Reports 35.5 (2016): 3025-3033.
Chicago
Che, Y., Ren, X., Xu, L., Ding, X., Zhang, X., Sun, X."Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia". Oncology Reports 35, no. 5 (2016): 3025-3033. https://doi.org/10.3892/or.2016.4673
Copy and paste a formatted citation
x
Spandidos Publications style
Che Y, Ren X, Xu L, Ding X, Zhang X and Sun X: Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia. Oncol Rep 35: 3025-3033, 2016.
APA
Che, Y., Ren, X., Xu, L., Ding, X., Zhang, X., & Sun, X. (2016). Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia. Oncology Reports, 35, 3025-3033. https://doi.org/10.3892/or.2016.4673
MLA
Che, Y., Ren, X., Xu, L., Ding, X., Zhang, X., Sun, X."Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia". Oncology Reports 35.5 (2016): 3025-3033.
Chicago
Che, Y., Ren, X., Xu, L., Ding, X., Zhang, X., Sun, X."Critical involvement of the α(1,2)-fucosyltransferase in multidrug resistance of human chronic myeloid leukemia". Oncology Reports 35, no. 5 (2016): 3025-3033. https://doi.org/10.3892/or.2016.4673
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