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Article

Stromal interaction molecule 1 plays an important role in gastric cancer progression

  • Authors:
    • Jin-Mei Xu
    • Yan Zhou
    • Long Gao
    • Shu-Xian Zhou
    • Wei-Hua Liu
    • Xiao-An Li
  • View Affiliations / Copyright

    Affiliations: The Gastroenterology Tumor and Microenvironment Laboratory, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Xindu, Chengdu, Sichuan 610041, P.R. China
  • Pages: 3496-3504
    |
    Published online on: March 24, 2016
       https://doi.org/10.3892/or.2016.4704
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Abstract

Studies have shown that stromal interaction molecule 1 (STIM1) is expressed in a variety of cancers and is related to tumor growth. The present study aimed to investigate the expression and roles of STIM1 in gastric carcinoma. Immunohistochemistry and western blotting revealed that STIM1 was expressed at higher levels in gastric cancer tissues (82%) than these levels in normal gastric tissues (42%). In addition, STIM1 was also expressed in tumor vascular endothelial cells. The effects of STIM1 on proliferation, apoptosis, adhesion, invasion and migration of gastric cancer cells were detected by MTT assay, flow cytometry, cell adhesion assay and Transwell assay, respectively. The results shown that STIM1 knockdown did not alter proliferation or apoptosis, but promoted cell adhesion and inhibited migration and invasion in the gastric cancer cells. In addition, STIM1 knockdown did not alter the expression or phosphorylation of mitogen-activated protein kinase (MEK) or extracellular signal-regulated kinase (ERK), implying that STIM1 affected gastric cancer cell migration through a pathway independent of the MEK/ERK pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Zhou Y, Gao L, Zhou S, Liu W and Li X: Stromal interaction molecule 1 plays an important role in gastric cancer progression. Oncol Rep 35: 3496-3504, 2016.
APA
Xu, J., Zhou, Y., Gao, L., Zhou, S., Liu, W., & Li, X. (2016). Stromal interaction molecule 1 plays an important role in gastric cancer progression. Oncology Reports, 35, 3496-3504. https://doi.org/10.3892/or.2016.4704
MLA
Xu, J., Zhou, Y., Gao, L., Zhou, S., Liu, W., Li, X."Stromal interaction molecule 1 plays an important role in gastric cancer progression". Oncology Reports 35.6 (2016): 3496-3504.
Chicago
Xu, J., Zhou, Y., Gao, L., Zhou, S., Liu, W., Li, X."Stromal interaction molecule 1 plays an important role in gastric cancer progression". Oncology Reports 35, no. 6 (2016): 3496-3504. https://doi.org/10.3892/or.2016.4704
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Zhou Y, Gao L, Zhou S, Liu W and Li X: Stromal interaction molecule 1 plays an important role in gastric cancer progression. Oncol Rep 35: 3496-3504, 2016.
APA
Xu, J., Zhou, Y., Gao, L., Zhou, S., Liu, W., & Li, X. (2016). Stromal interaction molecule 1 plays an important role in gastric cancer progression. Oncology Reports, 35, 3496-3504. https://doi.org/10.3892/or.2016.4704
MLA
Xu, J., Zhou, Y., Gao, L., Zhou, S., Liu, W., Li, X."Stromal interaction molecule 1 plays an important role in gastric cancer progression". Oncology Reports 35.6 (2016): 3496-3504.
Chicago
Xu, J., Zhou, Y., Gao, L., Zhou, S., Liu, W., Li, X."Stromal interaction molecule 1 plays an important role in gastric cancer progression". Oncology Reports 35, no. 6 (2016): 3496-3504. https://doi.org/10.3892/or.2016.4704
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