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Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer

  • Authors:
    • Chunliang Shang
    • Wenhui Zhu
    • Tianyu Liu
    • Wei Wang
    • Guangxin Huang
    • Jiaming Huang
    • Peizhen Zhao
    • Yunhe Zhao
    • Shuzhong Yao
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China, Department of Preventive Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China, Department of Joint Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P.R. China, Faculty of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, P.R. China
    Copyright: © Shang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3185-3197
    |
    Published online on: March 29, 2016
       https://doi.org/10.3892/or.2016.4715
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Abstract

Pelvic lymph node metastasis (PLNM) is an independent prognostic parameter and determines the treatment strategies of cervical cancer. Increasing evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in the process of tumor biological functions. This study aimed to mine lymph node metastasis-associated lncRNAs and investigate their potential pathophysiological mechanism in cervical cancer lymph node metastasis. We applied the lncRNA-mining approach to identify lncRNA transcripts represented on Affymetrix human genome U133 plus 2.0 microarrays from Gene Expression Omnibus (GEO) and then by validation in clinical specimens. The biological role and molecular mechanism of these lncRNAs were predicted by bioinformatic analysis. Subsequently, a receiver operating characteristic (ROC) curve and survival curve were conducted to evaluate the diagnostic and prognostic value of candidate lncRNAs. In total, 234 differentially expressed lncRNAs were identified to significantly associate with pelvic lymph node metastasis in early-stage cervical cancer. Our qRT-PCR results were consistent with the mining analysis (P<0.05). The functional enrichment analysis suggested that these lncRNAs may be involved in the biological process of lymph node metastasis. The ROC curves demonstrated satisfactory discrimination power of MIR100HG and AC024560.2 with areas under the curve of 0.801 and 0.837, respectively. Survival curve also indicated that patients with high MIR100HG expression had a tendency of poor prognosis. This is the first study to successfully mine the lncRNA expression patterns in PLNM of early-stage cervical cancer. MIR100HG and AC024560.2 may be a potential biomarkers of PLNM and these lncRNAs may provide broader perspective for combating cervical cancer metastasis.
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View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Carlson RW, Larsen JK, McClure J, Fitzgerald CL, Venook AP, Benson AB III and Anderson BO: International adaptations of NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 12:643–648. 2014.PubMed/NCBI

3 

Selman TJ, Mann C, Zamora J, Appleyard TL and Khan K: Diagnostic accuracy of tests for lymph node status in primary cervical cancer: A systematic review and meta-analysis. CMAJ. 178:855–862. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Landoni F, Maneo A, Colombo A, Placa F, Milani R, Perego P, Favini G, Ferri L and Mangioni C: Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer. Lancet. 350:535–540. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Hosaka M, Watari H, Mitamura T, Konno Y, Odagiri T, Kato T, Takeda M and Sakuragi N: Survival and prognosticators of node-positive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy. Int J Clin Oncol. 16:33–38. 2011. View Article : Google Scholar

6 

Dong Y, Wang X, Wang Y, Liu Y, Zhang J, Qian W and Wu S: Validity of 18F-fluorodeoxyglucose positron emission tomography/computed tomography for pretreatment evaluation of patients with cervical carcinoma: A retrospective pathology-matched study. Int J Gynecol Cancer. 24:1642–1647. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Nogami Y, Banno K, Irie H, Iida M, Kisu I, Masugi Y, Tanaka K, Tominaga E, Okuda S, Murakami K, et al: The efficacy of preoperative positron emission tomography-computed tomography (PET-CT) for detection of lymph node metastasis in cervical and endometrial cancer: Clinical and pathological factors influencing it. Jpn J Clin Oncol. 45:26–34. 2015. View Article : Google Scholar

8 

Diaz JP, Gemignani ML, Pandit-Taskar N, Park KJ, Murray MP, Chi DS, Sonoda Y, Barakat RR and Abu-Rustum NR: Sentinel lymph node biopsy in the management of early-stage cervical carcinoma. Gynecol Oncol. 120:347–352. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Grigsby PW, Watson M, Powell MA, Zhang Z and Rader JS: Gene expression patterns in advanced human cervical cancer. Int J Gynecol Cancer. 16:562–567. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Wang W, Jia HL, Huang JM, Liang YC, Tan H, Geng HZ, Guo LY and Yao SZ: Identification of biomarkers for lymph node metastasis in early-stage cervical cancer by tissue-based proteomics. Br J Cancer. 110:1748–1758. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Kim T, Choi J, Kim WY, Choi CH, Lee J, Bae D, Son D, Kim J, Park BK, Ahn G, et al: Gene expression profiling for the prediction of lymph node metastasis in patients with cervical cancer. Cancer Sci. 99:31–38. 2008.

12 

Huang L, Zheng M, Zhou QM, Zhang MY, Jia WH, Yun JP and Wang HY: Identification of a gene-expression signature for predicting lymph node metastasis in patients with early stage cervical carcinoma. Cancer. 117:3363–3373. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Biewenga P, Buist MR, Moerland PD, Ver Loren van Themaat E, van Kampen AHC, ten Kate FJW and Baas F: Gene expression in early stage cervical cancer. Gynecol Oncol. 108:520–526. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Bhan A and Mandal SS: Long noncoding RNAs: Emerging stars in gene regulation, epigenetics and human disease. Chem Med Chem. 9:1932–1956. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Sun NX, Ye C, Zhao Q, Zhang Q, Xu C, Wang SB, Jin ZJ, Sun SH, Wang F and Li W: Long noncoding RNA-EBIC promotes tumor cell invasion by binding to EZH2 and repressing E-cadherin in cervical cancer. PLoS One. 9:e1003402014. View Article : Google Scholar : PubMed/NCBI

16 

Cao S, Liu W, Li F, Zhao W and Qin C: Decreased expression of lncRNA GAS5 predicts a poor prognosis in cervical cancer. Int J Clin Exp Pathol. 7:6776–6783. 2014.PubMed/NCBI

17 

Huang L, Liao LM, Liu AW, Wu JB, Cheng XL, Lin JX and Zheng M: Overexpression of long noncoding RNA HOTAIR predicts a poor prognosis in patients with cervical cancer. Arch Gynecol Obstet. 290:717–723. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Noordhuis MG, Fehrmann RSN, Wisman GBA, Nijhuis ER, van Zanden JJ, Moerland PD, Ver Loren, van Themaat E, Volders HH, Kok M, ten Hoor KA, et al: Involvement of the TGF-beta and beta-catenin pathways in pelvic lymph node metastasis in early-stage cervical cancer. Clin Cancer Res. 17:1317–1330. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Zhang X, Sun S, Pu JKS, Tsang ACO, Lee D, Man VOY, Lui WM, Wong STS and Leung GKK: Long non-coding RNA expression profiles predict clinical phenotypes in glioma. Neurobiol Dis. 48:1–8. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Yang F, Zhang L, Huo XS, Yuan JH, Xu D, Yuan SX, Zhu N, Zhou WP, Yang GS, Wang YZ, et al: Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology. 54:1679–1689. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Michiels S, Koscielny S and Hill C: Prediction of cancer outcome with microarrays: A multiple random validation strategy. Lancet. 365:488–492. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Adler J and Parmryd I: Quantifying colocalization by correlation: The Pearson correlation coefficient is superior to the Mander's overlap coefficient. Cytometry A. 77:733–742. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Liu JB, Dai CM, Su XY, Cao L, Qin R and Kong QB: Gene microarray assessment of multiple genes and signal pathways involved in androgen-dependent prostate cancer becoming androgen independent. Asian Pac J Cancer Prev. 15:9791–9795. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al The Gene Ontology Consortium: Gene ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 102:15545–15550. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Liao Q, Liu C, Yuan X, Kang S, Miao R, Xiao H, Zhao G, Luo H, Bu D, Zhao H, et al: Large-scale prediction of long non-coding RNA functions in a coding-non-coding gene co-expression network. Nucleic Acids Res. 39:3864–3878. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Macdonald AI, Sun P, Hernandez-Lopez H, Aasen T, Hodgins MB, Edward M, Roberts S, Massimi P, Thomas M, Banks L, et al: A functional interaction between the MAGUK protein hDlg and the gap junction protein connexin 43 in cervical tumour cells. Biochem J. 446:9–21. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Emmrich S, Streltsov A, Schmidt F, Thangapandi VR, Reinhardt D and Klusmann JH: LincRNAs MONC and MIR100HG act as oncogenes in acute megakaryoblastic leukemia. Mol Cancer. 13:1712014. View Article : Google Scholar : PubMed/NCBI

29 

Iancu IV, Botezatu A, Goia-Ruşanu CD, Stănescu A, Huică I, Nistor E, Anton G and Pleşa A: TGF-beta signalling pathway factors in HPV-induced cervical lesions. Roum Arch Microbiol Immunol. 69:113–118. 2010.

30 

Chen Q, Cao HZ and Zheng PS: LGR5 promotes the proliferation and tumor formation of cervical cancer cells through the Wnt/β-catenin signaling pathway. Oncotarget. 5:9092–9105. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Yang G, Lu X and Yuan L: LncRNA: A link between RNA and cancer. Biochim Biophys Acta. 1839:1097–1109. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Hu Y, Chen HY, Yu CY, Xu J, Wang JL, Qian J, Zhang X and Fang JY: A long non-coding RNA signature to improve prognosis prediction of colorectal cancer. Oncotarget. 5:2230–2242. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Lampe PD and Lau AF: The effects of connexin phosphorylation on gap junctional communication. Int J Biochem Cell Biol. 36:1171–1186. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Steinhoff I, Leykauf K, Bleyl U, Dürst M and Alonso A: Phosphorylation of the gap junction protein Connexin43 in CIN III lesions and cervical carcinomas. Cancer Lett. 235:291–297. 2006. View Article : Google Scholar

35 

Broustas CG, Gokhale PC, Rahman A, Dritschilo A, Ahmad I and Kasid U: BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. J Biol Chem. 279:26780–26788. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM and Lippman SM: The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc Natl Acad Sci USA. 100:9968–9973. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Shang C, Zhu W, Liu T, Wang W, Huang G, Huang J, Zhao P, Zhao Y and Yao S: Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer. Oncol Rep 35: 3185-3197, 2016.
APA
Shang, C., Zhu, W., Liu, T., Wang, W., Huang, G., Huang, J. ... Yao, S. (2016). Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer. Oncology Reports, 35, 3185-3197. https://doi.org/10.3892/or.2016.4715
MLA
Shang, C., Zhu, W., Liu, T., Wang, W., Huang, G., Huang, J., Zhao, P., Zhao, Y., Yao, S."Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer". Oncology Reports 35.6 (2016): 3185-3197.
Chicago
Shang, C., Zhu, W., Liu, T., Wang, W., Huang, G., Huang, J., Zhao, P., Zhao, Y., Yao, S."Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer". Oncology Reports 35, no. 6 (2016): 3185-3197. https://doi.org/10.3892/or.2016.4715
Copy and paste a formatted citation
x
Spandidos Publications style
Shang C, Zhu W, Liu T, Wang W, Huang G, Huang J, Zhao P, Zhao Y and Yao S: Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer. Oncol Rep 35: 3185-3197, 2016.
APA
Shang, C., Zhu, W., Liu, T., Wang, W., Huang, G., Huang, J. ... Yao, S. (2016). Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer. Oncology Reports, 35, 3185-3197. https://doi.org/10.3892/or.2016.4715
MLA
Shang, C., Zhu, W., Liu, T., Wang, W., Huang, G., Huang, J., Zhao, P., Zhao, Y., Yao, S."Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer". Oncology Reports 35.6 (2016): 3185-3197.
Chicago
Shang, C., Zhu, W., Liu, T., Wang, W., Huang, G., Huang, J., Zhao, P., Zhao, Y., Yao, S."Characterization of long non-coding RNA expression profiles in lymph node metastasis of early-stage cervical cancer". Oncology Reports 35, no. 6 (2016): 3185-3197. https://doi.org/10.3892/or.2016.4715
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