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Article

MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN

  • Authors:
    • Jiansong Chen
    • Dingding Yan
    • Weiliang Wu
    • Jian Zhu
    • Wensong Ye
    • Qiang Shu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Children's Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, P.R. China, Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, P.R. China, Department of Tumor Surgery, Children's Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, P.R. China
  • Pages: 3285-3292
    |
    Published online on: March 31, 2016
       https://doi.org/10.3892/or.2016.4719
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Abstract

MicroRNAs, which serve as post-transcriptional modulators of numerous genes, have been found to be important regulators during the pathogenesis of osteosarcoma. This study demonstrates for the first time that microRNA-130a (miR-130a) is significantly upregulated in osteosarcoma, and associated with the metastasis of osteosarcoma. Elevated level of miR-130a was closely correlated with poor clinical features and prognosis of osteosarcoma patients. In vitro assays revealed that miR-130a could potentiate the migration, invasion and the epithelial-mesenchymal transtion (EMT) of osteosarcoma cells. Moreover, phosphatase and tensin homolog (PTEN) was confirmed as not only a direct downstream target but also a functional mediator of miR-130a. MiR-130a exerted promoting effects on metastatic behavior and EMT of osteosarcoma cells through suppressing PTEN expression. Based on these findings, we conclude that miR-130a is a promising prognostic biomarker for osteosarcoma patients, and targeting miR-130a may be a potential treatment option for osteosarcoma patients with metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Yan D, Wu W, Zhu J, Ye W and Shu Q: MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN. Oncol Rep 35: 3285-3292, 2016.
APA
Chen, J., Yan, D., Wu, W., Zhu, J., Ye, W., & Shu, Q. (2016). MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN. Oncology Reports, 35, 3285-3292. https://doi.org/10.3892/or.2016.4719
MLA
Chen, J., Yan, D., Wu, W., Zhu, J., Ye, W., Shu, Q."MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN". Oncology Reports 35.6 (2016): 3285-3292.
Chicago
Chen, J., Yan, D., Wu, W., Zhu, J., Ye, W., Shu, Q."MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN". Oncology Reports 35, no. 6 (2016): 3285-3292. https://doi.org/10.3892/or.2016.4719
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Yan D, Wu W, Zhu J, Ye W and Shu Q: MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN. Oncol Rep 35: 3285-3292, 2016.
APA
Chen, J., Yan, D., Wu, W., Zhu, J., Ye, W., & Shu, Q. (2016). MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN. Oncology Reports, 35, 3285-3292. https://doi.org/10.3892/or.2016.4719
MLA
Chen, J., Yan, D., Wu, W., Zhu, J., Ye, W., Shu, Q."MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN". Oncology Reports 35.6 (2016): 3285-3292.
Chicago
Chen, J., Yan, D., Wu, W., Zhu, J., Ye, W., Shu, Q."MicroRNA-130a promotes the metastasis and epithelial-mesenchymal transition of osteosarcoma by targeting PTEN". Oncology Reports 35, no. 6 (2016): 3285-3292. https://doi.org/10.3892/or.2016.4719
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