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Article

Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1

  • Authors:
    • Jun Luo
    • Cheng Zhang
    • Congyi Wang
    • Linjun Li
    • Chunhong Li
    • Qiang Li
    • Min Zhang
    • Qingchen Wu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, The First Affiliated Hospital, Chongqing Medical University, Yuzhong, Chongqing, P.R. China, Department of Cardiothoracic Surgery, People's Hospital of Changshou, Yuzhong, Chongqing, P.R. China, Department of Oncology, Suining Sichuan Center Hospital, Yuzhong, Sichuan, P.R. China
  • Pages: 3532-3540
    |
    Published online on: April 4, 2016
       https://doi.org/10.3892/or.2016.4731
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Abstract

Tumorigenesis results from various types of dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis and senescence. The transcription factor Myc-interacting zinc finger protein 1 (Miz-1) can either activate or repress gene expression in concert with binding partners including the Myc oncoprotein in several types of tumors. Known target genes of these complexes encode the cyclin‑dependent kinase inhibitors such as cdkn2b (p15) and cdkn1a (p21). In the present study, we showed that the silencing of Miz-1 expression, through shRNA in a lentiviral vector, influenced various biological processes in two types of esophageal carcinoma cell lines. Silencing of the expression of Miz-1 inhibited cell proliferation and promoted apoptosis in vitro. Loss of Miz-1 reduced the migration ability in esophageal carcinoma cells. High expression of p21 and downregulation of cyclin D1 accompanied the knockdown of Miz-1. Our data demonstrated that esophageal cancer has a cell cycle arrest pathway via Miz-1, p21 and cyclin D1.
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Copy and paste a formatted citation
Spandidos Publications style
Luo J, Zhang C, Wang C, Li L, Li C, Li Q, Zhang M and Wu Q: Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1. Oncol Rep 35: 3532-3540, 2016.
APA
Luo, J., Zhang, C., Wang, C., Li, L., Li, C., Li, Q. ... Wu, Q. (2016). Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1. Oncology Reports, 35, 3532-3540. https://doi.org/10.3892/or.2016.4731
MLA
Luo, J., Zhang, C., Wang, C., Li, L., Li, C., Li, Q., Zhang, M., Wu, Q."Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1". Oncology Reports 35.6 (2016): 3532-3540.
Chicago
Luo, J., Zhang, C., Wang, C., Li, L., Li, C., Li, Q., Zhang, M., Wu, Q."Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1". Oncology Reports 35, no. 6 (2016): 3532-3540. https://doi.org/10.3892/or.2016.4731
Copy and paste a formatted citation
x
Spandidos Publications style
Luo J, Zhang C, Wang C, Li L, Li C, Li Q, Zhang M and Wu Q: Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1. Oncol Rep 35: 3532-3540, 2016.
APA
Luo, J., Zhang, C., Wang, C., Li, L., Li, C., Li, Q. ... Wu, Q. (2016). Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1. Oncology Reports, 35, 3532-3540. https://doi.org/10.3892/or.2016.4731
MLA
Luo, J., Zhang, C., Wang, C., Li, L., Li, C., Li, Q., Zhang, M., Wu, Q."Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1". Oncology Reports 35.6 (2016): 3532-3540.
Chicago
Luo, J., Zhang, C., Wang, C., Li, L., Li, C., Li, Q., Zhang, M., Wu, Q."Miz-1 promotes the proliferation of esophageal cancer cells via suppression of p21 and release of p21-arrested cyclin D1". Oncology Reports 35, no. 6 (2016): 3532-3540. https://doi.org/10.3892/or.2016.4731
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