Open Access

Tumor-suppressing roles of miR-214 and miR-218 in breast cancer

  • Authors:
    • Bo Liu
    • Yanfeng Tian
    • Fang Li
    • Zengren Zhao
    • Xia Jiang
    • Congjie Zhai
    • Xiaodong Han
    • Like Zhang
  • View Affiliations

  • Published online on: April 15, 2016     https://doi.org/10.3892/or.2016.4749
  • Pages: 3178-3184
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that are key post-transcriptional regulators of gene expression. MicroRNA-214 (miR-214) and microRNA-218 (miR-218) have shown the function of tumor suppressors in various types of human cancers. However, the biological functions of miR-214 and miR-218 in breast cancer have not been elucidated completely. The present study evaluated the expression and biological function of miR-214 and miR-218 in human breast cancer. Our results revealed that the expression of miR-214 and miR-218 were significantly decreased in breast cancer tissues compared with adjacent tissues. The aberrant expression of miR-214 and miR-218 were negatively associated with Ki-67, and the miR-218 expression was positively associated with progesterone receptor (PR) in breast cancer tissues. In vitro, the cell proliferation and migration were decreased, cell apoptosis was induced, and cell cycle was also disturbed in miR-214 or miR-218 overexpressed breast cancer cells. Our results demonstrated that miR-214 and miR-218 function as tumor suppressors in breast cancer, and may become biomarkers and potential therapeutic targets in breast cancer.
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June-2016
Volume 35 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Liu B, Tian Y, Li F, Zhao Z, Jiang X, Zhai C, Han X and Zhang L: Tumor-suppressing roles of miR-214 and miR-218 in breast cancer. Oncol Rep 35: 3178-3184, 2016
APA
Liu, B., Tian, Y., Li, F., Zhao, Z., Jiang, X., Zhai, C. ... Zhang, L. (2016). Tumor-suppressing roles of miR-214 and miR-218 in breast cancer. Oncology Reports, 35, 3178-3184. https://doi.org/10.3892/or.2016.4749
MLA
Liu, B., Tian, Y., Li, F., Zhao, Z., Jiang, X., Zhai, C., Han, X., Zhang, L."Tumor-suppressing roles of miR-214 and miR-218 in breast cancer". Oncology Reports 35.6 (2016): 3178-3184.
Chicago
Liu, B., Tian, Y., Li, F., Zhao, Z., Jiang, X., Zhai, C., Han, X., Zhang, L."Tumor-suppressing roles of miR-214 and miR-218 in breast cancer". Oncology Reports 35, no. 6 (2016): 3178-3184. https://doi.org/10.3892/or.2016.4749