Tumor metastatic promoter ABCE1 interacts with the cytoskeleton protein actin and increases cell motility

  • Authors:
    • Xu Han
    • Ye Tian
    • Dali Tian
  • View Affiliations

  • Published online on: April 19, 2016     https://doi.org/10.3892/or.2016.4751
  • Pages: 3623-3629
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Abstract

ABCE1, a member of the ATP-binding cassette (ABC) family, is a candidate tumor metastatic promoter in lung cancer. Overexpression of ABCE1 is correlated with aggressive growth and metastasis in lung cancer cells. However, the exact mechanism remains unclear. In the present study, GST pull-down assay provided evidence of the possible interaction between ABCE1 and β-actin using GST-ABCE1 as a bait protein. Co-immunoprecipitation manifested ABCE1 formed complexes with β-actin in vivo. ABCE1 overexpression significantly increased the migration of lung cancer cells which may be attributed to the promotion of F-actin rearrangements. Taken together, these data suggest that overexpression of ABCE1 produces an obvious effect on the motility of lung cancer cells through cytoskeleton rearrangement.
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June-2016
Volume 35 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Han X, Tian Y and Tian D: Tumor metastatic promoter ABCE1 interacts with the cytoskeleton protein actin and increases cell motility. Oncol Rep 35: 3623-3629, 2016
APA
Han, X., Tian, Y., & Tian, D. (2016). Tumor metastatic promoter ABCE1 interacts with the cytoskeleton protein actin and increases cell motility. Oncology Reports, 35, 3623-3629. https://doi.org/10.3892/or.2016.4751
MLA
Han, X., Tian, Y., Tian, D."Tumor metastatic promoter ABCE1 interacts with the cytoskeleton protein actin and increases cell motility". Oncology Reports 35.6 (2016): 3623-3629.
Chicago
Han, X., Tian, Y., Tian, D."Tumor metastatic promoter ABCE1 interacts with the cytoskeleton protein actin and increases cell motility". Oncology Reports 35, no. 6 (2016): 3623-3629. https://doi.org/10.3892/or.2016.4751