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Article

SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways

  • Authors:
    • Jinghui Yang
    • Qiwei Yang
    • Jing Yu
    • Ximeng Li
    • Shan Yu
    • Xuewen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatopancreatobiliary Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, Central Laboratory, Second Hospital, Jilin University, Changchun, Jilin 130041, P.R. China, Department of Nephrology, China-Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China, Central Laboratory, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130012, P.R. China, Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China
  • Pages: 3566-3576
    |
    Published online on: April 20, 2016
       https://doi.org/10.3892/or.2016.4757
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Abstract

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (SPOCK1) has been reported to promote the growth and progression of various tumors. In this study, we focus on assessing the effect of SPOCK1 on proliferation, migration and invasion in glioma cells and elucidating its related mechanisms. The results of our present study demonstrated that overexpression of SPOCK1 promoted the proliferation and inhibited apoptosis in glioma cells. Additionally, overexpression of SPOCK1 promoted the migration and invasion potential of glioma cells. Moreover, we demonstrated that PI3K/AKT and Wnt/β-catenin signaling pathways were activated by SPOCK1 over­expression. SPOCK1 silencing has precisely the opposite effect. In conclusion, our study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K/AKT and Wnt/β-catenin pathways, which provides a potential theoretical basis for clinical treatment of glioma.
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1 

Taylor LP: Diagnosis, treatment, and prognosis of glioma: Five new things. Neurology. 75(Suppl 1): S28–S32. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Brada M, Stenning S, Gabe R, Thompson LC, Levy D, Rampling R, Erridge S, Saran F, Gattamaneni R, Hopkins K, et al: Temozolomide versus procarbazine, lomustine, and vincristine in recurrent high-grade glioma. J Clin Oncol. 28:4601–4608. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Morris PG and Lassman AB: Medical oncology: Optimizing chemotherapy and radiotherapy for anaplastic glioma. Nat Rev Clin Oncol. 7:428–430. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Gabayan AJ, Green SB, Sanan A, Jenrette J, Schultz C, Papagikos M, Tatter SP, Patel A, Amin P, Lustig R, et al: GliaSite brachytherapy for treatment of recurrent malignant gliomas: A retrospective multi-institutional analysis. Neurosurgery. 58:701–709; discussion 701–709. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Sciumè G, Santoni A and Bernardini G: Chemokines and glioma: Invasion and more. J Neuroimmunol. 224:8–12. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Butowski NA, Sneed PK and Chang SM: Diagnosis and treatment of recurrent high-grade astrocytoma. J Clin Oncol. 24:1273–1280. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Song X, Han P, Liu J, Wang Y, Li D, He J, Gong J, Li M, Tu W, Yan W, et al: Up-regulation of SPOCK1 induces epithelial-mesenchymal transition and promotes migration and invasion in esophageal squamous cell carcinoma. J Mol Histol. 46:347–356. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Miao L, Wang Y, Xia H, Yao C, Cai H and Song Y: SPOCK1 is a novel transforming growth factor-β target gene that regulates lung cancer cell epithelial-mesenchymal transition. Biochem Biophys Res Commun. 440:792–797. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Li Y, Chen L, Chan TH, Liu M, Kong KL, Qiu JL, Li Y, Yuan YF and Guan XY: SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. Gastroenterology. 144:179–191.e4. 2013. View Article : Google Scholar

10 

Shu YJ, Weng H, Ye YY, Hu YP, Bao RF, Cao Y, Wang XA, Zhang F, Xiang SS, Li HF, et al: SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway. Mol Cancer. 14:122015. View Article : Google Scholar : PubMed/NCBI

11 

Colin C, Baeza N, Bartoli C, Fina F, Eudes N, Nanni I, Martin PM, Ouafik L and Figarella-Branger D: Identification of genes differentially expressed in glioblastoma versus pilocytic astrocytoma using suppression subtractive hybridization. Oncogene. 25:2818–2826. 2006. View Article : Google Scholar

12 

Taillibert S, Pedretti M and Sanson M: Current classification of gliomas. Presse Med. 33:1274–1277. 2004.In French. View Article : Google Scholar : PubMed/NCBI

13 

Beetz C, Bergner S, Brodoehl S, Brodhun M, Ewald C, Kalff R, Krüger J, Patt S, Kiehntopf M and Deufel T: Outcome-based profiling of astrocytic tumours identifies prognostic gene expression signatures which link molecular and morphology-based pathology. Int J Oncol. 29:1183–1191. 2006.PubMed/NCBI

14 

Kayaselçuk F, Zorludemir S, Gümürdühü D, Zeren H and Erman T: PCNA and Ki-67 in central nervous system tumors: Correlation with the histological type and grade. J Neurooncol. 57:115–121. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, et al: Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 287:14289–14300. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Alderson LM, Castleberg RL, Harsh GR IV, Louis DN and Henson JW: Human gliomas with wild-type p53 express bcl-2. Cancer Res. 55:999–1001. 1995.PubMed/NCBI

17 

Deckert-Schlüter M, Rang A and Wiestler OD: Apoptosis and apoptosis-related gene products in primary non-Hodgkin's lymphoma of the central nervous system. Acta Neuropathol. 96:157–162. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Rossé T, Olivier R, Monney L, Rager M, Conus S, Fellay I, Jansen B and Borner C: Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature. 391:496–499. 1998. View Article : Google Scholar : PubMed/NCBI

19 

Borner C: The Bcl-2 protein family: Sensors and checkpoints for life-or-death decisions. Mol Immunol. 39:615–647. 2003. View Article : Google Scholar

20 

Porter AG and Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 6:99–104. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Lin C, Holland RE Jr, Donofrio JC, McCoy MH, Tudor LR and Chambers TM: Caspase activation in equine influenza virus induced apoptotic cell death. Vet Microbiol. 84:357–365. 2002. View Article : Google Scholar

22 

Brown GT and Murray GI: Current mechanistic insights into the roles of matrix metalloproteinases in tumour invasion and metastasis. J Pathol. 237:273–281. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Sawaya RE, Yamamoto M, Gokaslan ZL, Wang SW, Mohanam S, Fuller GN, McCutcheon IE, Stetler-Stevenson WG, Nicolson GL and Rao JS: Expression and localization of 72 kDa type IV collagenase (MMP-2) in human malignant gliomas in vivo. Clin Exp Metastasis. 14:35–42. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Rao JS, Steck PA, Mohanam S, Stetler-Stevenson WG, Liotta LA and Sawaya R: Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors. Cancer Res. 53(Suppl): 2208–2211. 1993.PubMed/NCBI

25 

Forsyth PA, Wong H, Laing TD, Rewcastle NB, Morris DG, Muzik H, Leco KJ, Johnston RN, Brasher PM, Sutherland G, et al: Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas. Br J Cancer. 79:1828–1835. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Sawaya R, Go Y, Kyritisis AP, Uhm J, Venkaiah B, Mohanam S, Gokaslan ZL and Rao JS: Elevated levels of Mr 92,000 type IV collagenase during tumor growth in vivo. Biochem Biophys Res Commun. 251:632–636. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Ströbele S, Schneider M, Schneele L, Siegelin MD, Nonnenmacher L, Zhou S, Karpel-Massler G, Westhoff MA, Halatsch ME and Debatin KM: A Potential role for the inhibition of PI3K signaling in glioblastoma therapy. PLoS One. 10:e01316702015. View Article : Google Scholar : PubMed/NCBI

28 

Jiao Y, Li H, Liu Y, Guo A, Xu X, Qu X, Wang S, Zhao J, Li Y and Cao Y: Resveratrol inhibits the invasion of glioblastoma-initiating cells via down-regulation of the PI3K/Akt/NF-κB signaling pathway. Nutrients. 7:4383–4402. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Shi L, Fei X, Wang Z and You Y: PI3K inhibitor combined with miR-125b inhibitor sensitize TMZ-induced anti-glioma stem cancer effects through inactivation of Wnt/β-catenin signaling pathway. In Vitro Cell Dev Biol Anim. 51:1047–1055. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Geuna E, Milani A, Martinello R, Aversa C, Valabrega G, Scaltriti M and Montemurro F: Buparlisib, an oral pan-PI3K inhibitor for the treatment of breast cancer. Expert Opin Investig Drugs. 24:421–431. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ku BM, Jho EH, Bae YH, Sun JM, Ahn JS, Park K and Ahn MJ: BYL719, a selective inhibitor of phosphoinositide 3-Kinase α, enhances the effect of selumetinib (AZD6244, ARRY-142886) in KRAS-mutant non-small cell lung cancer. Invest New Drugs. 33:12–21. 2015. View Article : Google Scholar

32 

Brabletz T, Herrmann K, Jung A, Faller G and Kirchner T: Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas. Am J Pathol. 156:865–870. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Yang N, Wang Y, Hui L, Li X and Jiang X: SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway. Tumour Biol. 36:8625–8635. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Lee KS, Kwak Y, Nam KH, Kim DW, Kang SB, Choe G, Kim WH and Lee HS: c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer. PLoS One. 10:e01397272015. View Article : Google Scholar : PubMed/NCBI

35 

Leone A, Roca MS, Ciardiello C, Terranova-Barberio M, Vitagliano C, Ciliberto G, Mancini R, Di Gennaro E, Bruzzese F and Budillon A: Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway. Free Radic Biol Med. 89:287–299. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Ouyang Q, Chen G, Zhou J, Li L, Dong Z, Yang R, Xu L, Cui H, Xu M and Yi L: Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p. Neuro Oncol. 18:216–226. 2016. View Article : Google Scholar

37 

Suk FM, Lin SY, Lin RJ, Hsine YH, Liao YJ, Fang SU and Liang YC: Bortezomib inhibits Burkitt's lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression. Oncotarget. 6:25988–26001. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Fu Q, Chen Z, Gong X, Cai Y, Chen Y, Ma X, Zhu R and Jin J: β-Catenin expression is regulated by an IRES-dependent mechanism and stimulated by paclitaxel in human ovarian cancer cells. Biochem Biophys Res Commun. 461:21–27. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Yang Q, Yu J, Li X, Yu S and Zhang X: SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways. Oncol Rep 35: 3566-3576, 2016.
APA
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., & Zhang, X. (2016). SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways. Oncology Reports, 35, 3566-3576. https://doi.org/10.3892/or.2016.4757
MLA
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., Zhang, X."SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways". Oncology Reports 35.6 (2016): 3566-3576.
Chicago
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., Zhang, X."SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways". Oncology Reports 35, no. 6 (2016): 3566-3576. https://doi.org/10.3892/or.2016.4757
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Yang Q, Yu J, Li X, Yu S and Zhang X: SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways. Oncol Rep 35: 3566-3576, 2016.
APA
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., & Zhang, X. (2016). SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways. Oncology Reports, 35, 3566-3576. https://doi.org/10.3892/or.2016.4757
MLA
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., Zhang, X."SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways". Oncology Reports 35.6 (2016): 3566-3576.
Chicago
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., Zhang, X."SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways". Oncology Reports 35, no. 6 (2016): 3566-3576. https://doi.org/10.3892/or.2016.4757
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