SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways

  • Authors:
    • Jinghui Yang
    • Qiwei Yang
    • Jing Yu
    • Ximeng Li
    • Shan Yu
    • Xuewen Zhang
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  • Published online on: April 20, 2016     https://doi.org/10.3892/or.2016.4757
  • Pages: 3566-3576
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Abstract

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (SPOCK1) has been reported to promote the growth and progression of various tumors. In this study, we focus on assessing the effect of SPOCK1 on proliferation, migration and invasion in glioma cells and elucidating its related mechanisms. The results of our present study demonstrated that overexpression of SPOCK1 promoted the proliferation and inhibited apoptosis in glioma cells. Additionally, overexpression of SPOCK1 promoted the migration and invasion potential of glioma cells. Moreover, we demonstrated that PI3K/AKT and Wnt/β-catenin signaling pathways were activated by SPOCK1 over­expression. SPOCK1 silencing has precisely the opposite effect. In conclusion, our study suggests that SPOCK1 promotes proliferation, migration and invasion in glioma cells by activating PI3K/AKT and Wnt/β-catenin pathways, which provides a potential theoretical basis for clinical treatment of glioma.
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June-2016
Volume 35 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Yang J, Yang Q, Yu J, Li X, Yu S and Zhang X: SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways. Oncol Rep 35: 3566-3576, 2016
APA
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., & Zhang, X. (2016). SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways. Oncology Reports, 35, 3566-3576. https://doi.org/10.3892/or.2016.4757
MLA
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., Zhang, X."SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways". Oncology Reports 35.6 (2016): 3566-3576.
Chicago
Yang, J., Yang, Q., Yu, J., Li, X., Yu, S., Zhang, X."SPOCK1 promotes the proliferation, migration and invasion of glioma cells through PI3K/AKT and Wnt/β-catenin signaling pathways". Oncology Reports 35, no. 6 (2016): 3566-3576. https://doi.org/10.3892/or.2016.4757