S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation

  • Authors:
    • Teng Hua
    • Shuangge Liu
    • Xiaoyan Xin
    • Liqiong Cai
    • Rui Shi
    • Shuqi Chi
    • Dilu Feng
    • Hongbo Wang
  • View Affiliations

  • Published online on: April 20, 2016     https://doi.org/10.3892/or.2016.4760
  • Pages: 3419-3426
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Abstract

Epithelial-mesenchymal transition (EMT) is a major cause of endometrial cancer (EC) to initiate invasion and metastasis. S100A4, a calcium-binding protein, is implicated in multistage of tumorigenesis and tumor progression. The correlation between S100A4 and EMT in EC is still unclear. This study was aimed to clarify the role of S100A4 in EC and the relationship between S100A4 expression and EMT markers. S100A4, E-cadherin, and vimentin were detected in tissues of EC patients (n=50) by immunohistochemistry. The impact of S100A4 on EC cell proliferation, migration and invasion was investigated via RNA interference, and the correlation between S100A4 and EMT markers were also explored. The results showed that S100A4 was significantly increased in epithelial cells of EC compared with the normal endometrium (P<0.05), also S100A4 level was positively related to age (P=0.021), histological grade (P<0.001), and lymph node metastasis (P<0.001). Additionally, silencing of S100A4 remarkably attenuated EC cell migration and invasion. Significant morphological change accompanied with the downregulation of EMT markers, E-cadherin and vimentin were also observed. Aberrant S100A4 expression may predict EC progression and play an important role in regulating EC cell invasion through EMT regulation. Hence, S100A4 is a promising therapeutic target.
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June-2016
Volume 35 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hua T, Liu S, Xin X, Cai L, Shi R, Chi S, Feng D and Wang H: S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation. Oncol Rep 35: 3419-3426, 2016
APA
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S. ... Wang, H. (2016). S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation. Oncology Reports, 35, 3419-3426. https://doi.org/10.3892/or.2016.4760
MLA
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S., Feng, D., Wang, H."S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation". Oncology Reports 35.6 (2016): 3419-3426.
Chicago
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S., Feng, D., Wang, H."S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation". Oncology Reports 35, no. 6 (2016): 3419-3426. https://doi.org/10.3892/or.2016.4760