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Article

S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation

  • Authors:
    • Teng Hua
    • Shuangge Liu
    • Xiaoyan Xin
    • Liqiong Cai
    • Rui Shi
    • Shuqi Chi
    • Dilu Feng
    • Hongbo Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 3419-3426
    |
    Published online on: April 20, 2016
       https://doi.org/10.3892/or.2016.4760
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Abstract

Epithelial-mesenchymal transition (EMT) is a major cause of endometrial cancer (EC) to initiate invasion and metastasis. S100A4, a calcium-binding protein, is implicated in multistage of tumorigenesis and tumor progression. The correlation between S100A4 and EMT in EC is still unclear. This study was aimed to clarify the role of S100A4 in EC and the relationship between S100A4 expression and EMT markers. S100A4, E-cadherin, and vimentin were detected in tissues of EC patients (n=50) by immunohistochemistry. The impact of S100A4 on EC cell proliferation, migration and invasion was investigated via RNA interference, and the correlation between S100A4 and EMT markers were also explored. The results showed that S100A4 was significantly increased in epithelial cells of EC compared with the normal endometrium (P<0.05), also S100A4 level was positively related to age (P=0.021), histological grade (P<0.001), and lymph node metastasis (P<0.001). Additionally, silencing of S100A4 remarkably attenuated EC cell migration and invasion. Significant morphological change accompanied with the downregulation of EMT markers, E-cadherin and vimentin were also observed. Aberrant S100A4 expression may predict EC progression and play an important role in regulating EC cell invasion through EMT regulation. Hence, S100A4 is a promising therapeutic target.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC, et al Cancer Genome Atlas Research Network: Integrated genomic characterization of endometrial carcinoma. Nature. 497:67–73. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Amant F, Mirza MR, Koskas M and Creutzberg CL: Cancer of the corpus uteri. Int J Gynaecol Obstet. 131(Suppl 2): S96–S104. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Psaila B and Lyden D: The metastatic niche: Adapting the foreign soil. Nat Rev Cancer. 9:285–293. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Valastyan S and Weinberg RA: Tumor metastasis: Molecular insights and evolving paradigms. Cell. 147:275–292. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Chen H, Xu C, Jin Q and Liu Z: S100 protein family in human cancer. Am J Cancer Res. 4:89–115. 2014.PubMed/NCBI

7 

Donato R, Cannon BR, Sorci G, Riuzzi F, Hsu K, Weber DJ and Geczy CL: Functions of S100 proteins. Curr Mol Med. 13:24–57. 2013. View Article : Google Scholar :

8 

Lee SJ, Choi SY, Kim WJ, Ji M, Lee TG, Son BR, Yoon SM, Sung R, Lee EJ, Youn SJ, et al: Combined aberrant expression of E-cadherin and S100A4, but not β-catenin is associated with disease-free survival and overall survival in colorectal cancer patients. Diagn Pathol. 8:992013. View Article : Google Scholar

9 

Dahlmann M, Okhrimenko A, Marcinkowski P, Osterland M, Herrmann P, Smith J, Heizmann CW, Schlag PM and Stein U: RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis. Oncotarget. 5:3220–3233. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Lee SH, Kim H, Hwang JH, Shin E, Lee HS, Hwang DW, Cho JY, Yoon YS, Han HS and Cha BH: CD24 and S100A4 expression in resectable pancreatic cancers with earlier disease recurrence and poor survival. Pancreas. 43:380–388. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke KD and Stein U: Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker. World J Gastroenterol. 21:333–341. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Hernández JL, Padilla L, Dakhel S, Coll T, Hervas R, Adan J, Masa M, Mitjans F, Martinez JM, Coma S, et al: Therapeutic targeting of tumor growth and angiogenesis with a novel anti-S100A4 monoclonal antibody. PLoS One. 8:e724802013. View Article : Google Scholar : PubMed/NCBI

13 

Chong HI, Lee JH, Yoon MS, Suh DS, Kim K, Kim JY and Choi KU: Prognostic value of cytoplasmic expression of S100A4 protein in endometrial carcinoma. Oncol Rep. 31:2701–2707. 2014.PubMed/NCBI

14 

Xie R, Loose DS, Shipley GL, Xie S, Bassett RL Jr and Broaddus RR: Hypomethylation-induced expression of S100A4 in endometrial carcinoma. Mod Pathol. 20:1045–1054. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Zheng H and Kang Y: Multilayer control of the EMT master regulators. Oncogene. 33:1755–1763. 2014. View Article : Google Scholar

17 

Kidd ME, Shumaker DK and Ridge KM: The role of vimentin intermediate filaments in the progression of lung cancer. Am J Respir Cell Mol Biol. 50:1–6. 2014.

18 

Wang H, Shi J, Luo Y, Liao Q, Niu Y, Zhang F, Shao Z, Ding Y and Zhao L: LIM and SH3 protein 1 induces TGFβ-mediated epithelial-mesenchymal transition in human colorectal cancer by regulating S100A4 expression. Clin Cancer Res. 20:5835–5847. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Lo JF, Yu CC, Chiou SH, Huang CY, Jan CI, Lin SC, Liu CJ, Hu WY and Yu YH: The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers. Cancer Res. 71:1912–1923. 2011. View Article : Google Scholar

20 

Nitta T, Mitsuhashi T, Hatanaka Y, Miyamoto M, Oba K, Tsuchikawa T, Suzuki Y, Hatanaka KC, Hirano S and Matsuno Y: Prognostic significance of epithelial-mesenchymal transition-related markers in extrahepatic cholangiocarcinoma: Comprehensive immunohistochemical study using a tissue microarray. Br J Cancer. 111:1363–1372. 2014. View Article : Google Scholar : PubMed/NCBI

21 

McKiernan E, McDermott EW, Evoy D, Crown J and Duffy MJ: The role of S100 genes in breast cancer progression. Tumour Biol. 32:441–450. 2011. View Article : Google Scholar

22 

Rosty C, Ueki T, Argani P, Jansen M, Yeo CJ, Cameron JL, Hruban RH and Goggins M: Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol. 160:45–50. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Buetti-Dinh A, Pivkin IV and Friedman R: S100A4 and its role in metastasis - computational integration of data on biological networks. Mol Biosyst. 11:2238–2246. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Miranda KJ, Loeser RF and Yammani RR: Sumoylation and nuclear translocation of S100A4 regulate IL-1beta-mediated production of matrix metalloproteinase-13. J Biol Chem. 285:31517–31524. 2010. View Article : Google Scholar : PubMed/NCBI

25 

O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, et al: VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci USA. 108:16002–16007. 2011. View Article : Google Scholar

26 

Kim HM, Jung WH and Koo JS: Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: An immunohistochemical analysis. J Transl Med. 13:2222015. View Article : Google Scholar : PubMed/NCBI

27 

Kang YG, Jung CK, Lee A, Kang WK, Oh ST and Kang CS: Prognostic significance of S100A4 mRNA and protein expression in colorectal cancer. J Surg Oncol. 105:119–124. 2012. View Article : Google Scholar

28 

Jung EA, Cho HD, Lee JH and Oh MH: Clinicopathological significance of S100A4 expression in non-small cell lung carcinomas. Korean J Pathol. 44:477–482. 2010. View Article : Google Scholar

29 

Thiery JP and Sleeman JP: Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol. 7:131–142. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Yang WN, Ai ZH, Wang J, Xu YL and Teng YC: Correlation between the overexpression of epidermal growth factor receptor and mesenchymal makers in endometrial carcinoma. J Gynecol Oncol. 25:36–42. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Sack U, Walther W, Scudiero D, Selby M, Aumann J, Lemos C, Fichtner I, Schlag PM, Shoemaker RH and Stein U: S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells. Mol Biol Cell. 22:3344–3354. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Xie R, Schlumbrecht MP, Shipley GL, Xie S, Bassett RL Jr and Broaddus RR: S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling. Lab Invest. 89:937–947. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Knights AJ, Funnell AP, Crossley M and Pearson RC: Holding tight: Cell junctions and cancer spread. Trends Cancer Res. 8:61–69. 2012.PubMed/NCBI

34 

Goh Then Sin C, Hersch N, Rudland PS, Barraclough R, Hoffmann B and Gross SR: S100A4 downregulates filopodia formation through increased dynamic instability. Cell Adhes Migr. 5:439–447. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Hua T, Liu S, Xin X, Cai L, Shi R, Chi S, Feng D and Wang H: S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation. Oncol Rep 35: 3419-3426, 2016.
APA
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S. ... Wang, H. (2016). S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation. Oncology Reports, 35, 3419-3426. https://doi.org/10.3892/or.2016.4760
MLA
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S., Feng, D., Wang, H."S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation". Oncology Reports 35.6 (2016): 3419-3426.
Chicago
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S., Feng, D., Wang, H."S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation". Oncology Reports 35, no. 6 (2016): 3419-3426. https://doi.org/10.3892/or.2016.4760
Copy and paste a formatted citation
x
Spandidos Publications style
Hua T, Liu S, Xin X, Cai L, Shi R, Chi S, Feng D and Wang H: S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation. Oncol Rep 35: 3419-3426, 2016.
APA
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S. ... Wang, H. (2016). S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation. Oncology Reports, 35, 3419-3426. https://doi.org/10.3892/or.2016.4760
MLA
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S., Feng, D., Wang, H."S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation". Oncology Reports 35.6 (2016): 3419-3426.
Chicago
Hua, T., Liu, S., Xin, X., Cai, L., Shi, R., Chi, S., Feng, D., Wang, H."S100A4 promotes endometrial cancer progress through epithelial-mesenchymal transition regulation". Oncology Reports 35, no. 6 (2016): 3419-3426. https://doi.org/10.3892/or.2016.4760
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