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miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer

  • Authors:
    • Meisi Yan
    • Xiaobo Li
    • Dandan Tong
    • Changsong Han
    • Ran Zhao
    • Yan He
    • Xiaoming Jin
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 65-71
    |
    Published online on: April 25, 2016
       https://doi.org/10.3892/or.2016.4767
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Abstract

MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely unknown. Herein, we demonstrate that miR-136 is an anti-invasive microRNA in TNBC and suppresses mesenchymal invasion and metastasis. Our results demonstrated that miR-136 was downregulated in TNBC and negative correlated with the WHO grades. However, RASAL2 was identified as a functional target of miR-136, and was overexpressed in TNBC and correlates with pathological grades. Moreover, overexpression of RASAL2 in a breast cancer cell line rescued miR-136-mediated cell migration and invasion. In conclusion, these results indicate that the miR-136/RASAL2/MET axis act as a suppressor of TNBC metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Yan M, Li X, Tong D, Han C, Zhao R, He Y and Jin X: miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer. Oncol Rep 36: 65-71, 2016.
APA
Yan, M., Li, X., Tong, D., Han, C., Zhao, R., He, Y., & Jin, X. (2016). miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer. Oncology Reports, 36, 65-71. https://doi.org/10.3892/or.2016.4767
MLA
Yan, M., Li, X., Tong, D., Han, C., Zhao, R., He, Y., Jin, X."miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer". Oncology Reports 36.1 (2016): 65-71.
Chicago
Yan, M., Li, X., Tong, D., Han, C., Zhao, R., He, Y., Jin, X."miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer". Oncology Reports 36, no. 1 (2016): 65-71. https://doi.org/10.3892/or.2016.4767
Copy and paste a formatted citation
x
Spandidos Publications style
Yan M, Li X, Tong D, Han C, Zhao R, He Y and Jin X: miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer. Oncol Rep 36: 65-71, 2016.
APA
Yan, M., Li, X., Tong, D., Han, C., Zhao, R., He, Y., & Jin, X. (2016). miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer. Oncology Reports, 36, 65-71. https://doi.org/10.3892/or.2016.4767
MLA
Yan, M., Li, X., Tong, D., Han, C., Zhao, R., He, Y., Jin, X."miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer". Oncology Reports 36.1 (2016): 65-71.
Chicago
Yan, M., Li, X., Tong, D., Han, C., Zhao, R., He, Y., Jin, X."miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer". Oncology Reports 36, no. 1 (2016): 65-71. https://doi.org/10.3892/or.2016.4767
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