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Article

Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway

  • Authors:
    • Jian-Ying Li
    • Jun Yu
    • Xu-Sheng Du
    • Hui-Min Zhang
    • Bo Wang
    • Hua Guo
    • Jie Bai
    • Juan-Hong Wang
    • An Liu
    • Yi-Li Wang
  • View Affiliations / Copyright

    Affiliations: Institute of Cancer Research, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of General Surgery, Affiliated Second Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710003, P.R. China, Department of Respiratory Disease, Affiliated Xi'an Central Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710003, P.R. China, Department of Pathology, Affiliated Xi'an Central Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710003, P.R. China
  • Pages: 147-154
    |
    Published online on: May 4, 2016
       https://doi.org/10.3892/or.2016.4784
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Abstract

Lung cancer is the leading cause of cancer death in the world. Safflower polysaccharide (SPS) has been used for the improvement of immunomodulatory activities and treatment of cancers. However, studies on the effect of SPS on the progression of lung cancer have rarely been reported. To study the antitumor effect of SPS on human lung cancer and its potential mechanism, non-small cell lung cancer cell lines (NSCLC), A549 and YTMLC-90 were treated with SPS at various concentrations ranging from 0.04 to 2.56 mg/ml and BALB/c nude tumor-bearing mice were injected intraperitoneally with SPS at concentrations ranging from 15 to 135 mg/kg. Results showed that SPS suppressed the proliferation of A549 and YTMLC-90 cells and induced apoptosis by increasing mRNA levels of bax and caspase-3, and inhibited tumor growth in vivo. SPS induced cell cycle arrest in the G2/M phase by decreasing the expression of cdc25B and cyclin B1. Moreover, SPS decreased the expression of Akt, p-Akt and PI3K. In mice, SPS injection enhanced immunomodulatory activities by increasing levels of TNF-α and IL-6 in tumor-bearing mice. Our findings suggest that SPS suppresses tumor growth by enhancing immunomodulatory activities and blocking the PI3K/Akt pathway. This study provides new insight into the anticancer mechanism of SPS.
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1 

Lev-Ari S, Starr A, Katzburg S, Berkovich L, Rimmon A, Ben-Yosef R, Vexler A, Ron I and Earon G: Curcumin induces apoptosis and inhibits growth of orthotopic human non-small cell lung cancer xenografts. J Nutr Biochem. 25:843–850. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Liloglou T, Bediaga NG, Brown BR, Field JK and Davies MP: Epigenetic biomarkers in lung cancer. Cancer Lett. 342:200–212. 2014. View Article : Google Scholar

3 

Hennessy BT, Smith DL, Ram PT, Lu Y and Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 4:988–1004. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Zhu Z, Sun H, Ma G, Wang Z, Li E and Liu Y and Liu Y: Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway. Int J Mol Sci. 13:2025–2035. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Zhang X-Y, Kuang J-L, Yan C-S, Tu XY, Zhao JH, Cheng XS and Ye XQ: NRSN2 promotes non-small cell lung cancer cell growth through PI3K/Akt/mTOR pathway. Int J Clin Exp Pathol. 8:2574–2581. 2015.PubMed/NCBI

6 

Chew CL, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, et al: In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes. Cancer Discov. 5:740–751. 2015. View Article : Google Scholar :

7 

Xu X, Zhang Y, Qu D, Jiang T and Li S: Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway. J Exp Clin Cancer Res. 30:332011. View Article : Google Scholar : PubMed/NCBI

8 

Hou Z, Zhao W, Zhou J, Shen L, Zhan P, Xu C, Chang C, Bi H, Zou J, Yao X, et al: A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. Int J Biochem Cell Biol. 53:380–388. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Tian T, Li J, Li B, Wang Y, Li M, Ma D and Wang X: Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells. Tumour Biol. 35:4137–4145. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Zhou X, Tang L, Xu Y, Zhou G and Wang Z: Towards a better understanding of medicinal uses of Carthamus tinctorius L. in traditional Chinese medicine: A phytochemical and pharmacological review. J Ethnopharmacol. 151:27–43. 2014. View Article : Google Scholar

11 

Fan S, Lin N, Shan G, Zuo P and Cui L: Safflower yellow for acute ischemic stroke: A systematic review of randomized controlled trials. Complement Ther Med. 22:354–361. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Li LJ, Li YM, Qiao BY, Jiang S, Li X, Du HM, Han PC and Shi J: The value of safflower yellow injection for the treatment of acute cerebral infarction: A randomized controlled trial. Evid Based Complement Alternat Med. 2015:4787932015.PubMed/NCBI

13 

Liu Y, Tian X, Cui M and Zhao S: Safflower yellow inhibits angiotensin II-induced adventitial fibroblast proliferation and migration. J Pharmacol Sci. 126:107–114. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Toma W, Guimarães LL, Brito AR, Santos AR, Cortez FS, Pusceddu FH, Cesar A, Júnior LS, Pacheco MTT and Pereira CDS: Safflower oil: An integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity. Rev Bras Farmacogn. 24:538–544. 2014. View Article : Google Scholar

15 

Ali Sahari M, Morovati N, Barzegar M and Asgari S: Physicochemical and antioxidant characteristics of safflower seed oil. Curr Nutr Food Sci. 10:268–274. 2014. View Article : Google Scholar

16 

Luo Z, Zeng H, Ye Y, Liu L, Li S, Zhang J and Luo R: Safflower polysaccharide inhibits the proliferation and metastasis of MCF-7 breast cancer cell. Mol Med Rep. 11:4611–4616. 2015.PubMed/NCBI

17 

Sabah FS and Saleh AA: Evaluation of antibacterial activity of flavonoid and oil extracts from safflower (Carthamus tinctorius L.). J Nat Sci Res. 5:41–44. 2015.

18 

Yu J, Sun R, Zhao Z and Wang Y: Auricularia polytricha polysaccharides induce cell cycle arrest and apoptosis in human lung cancer A549 cells. Int J Biol Macromol. 68:67–71. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Kim Y-J, Choi W-I, Jeon B-N, Choi KC, Kim K, Kim TJ, Ham J, Jang HJ, Kang KS and Ko H: Stereospecific effects of ginsenoside 20-Rg3 inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses lung cancer migration, invasion and anoikis resistance. Toxicology. 322:23–33. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Xi SY, Zhang Q, Liu CY, Xie H, Yue LF and Gao XM: Effects of hydroxy safflower yellow-A on tumor capillary angiogenesis in transplanted human gastric adenocarcinoma BGC-823 tumors in nude mice. J Tradit Chin Med. 32:243–248. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Li W, Wu D, Wei B, Wang S, Sun H, Li X, Zhang F, Zhang C and Xin Y: Anti-tumor effect of cactus polysaccharides on lung squamous carcinoma cells (SK-MES-1). Afr J Tradit Complement Altern Med. 11:99–104. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Cui H, Wang C, Wang Y, Li Z, Zhang Y, Chen M and Li F: Pleurotus nebrodensis polysaccharide induces apoptosis in human non-small cell lung cancer A549 cells. Carbohydr Polym. 104:246–252. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Yang X, Yang Y, Tang S, Tang H, Yang G, Xu Q and Wu J: Anti-tumor effect of polysaccharides from Scutellaria barbata D. Don on the 95-D xenograft model via inhibition of the C-met pathway. J Pharmacol Sci. 125:255–263. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Sousa L, Garcia IJ, Costa TG, Silva LN, Renó CO, Oliveira ES, Tilelli CQ, Santos LL, Cortes VF, Santos HL, et al: Effects of iron overload on the activity of Na,K-ATPase and lipid profile of the human erythrocyte membrane. PLoS One. 10:e01328522015. View Article : Google Scholar : PubMed/NCBI

25 

Lu S-P and Zhao P-T: Chemical characterization of Lycium barbarum polysaccharides and their reducing myocardial injury in ischemia/reperfusion of rat heart. Int J Biol Macromol. 47:681–684. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Ji Y, Ji C and Wang C: Study on S180 Tumor Mice Erythrocyte Membrance Function of Sargassum Fusiform Polysaccharides. 7th Asian-Pacific Conference on Medical and Biological Engineering; Springer; pp. 531–533. 2008, https://www.researchgate.net/publication/226856649_Study_on_S180_Tumor_Mice_erythrocyte_Membrance_Function_of_Sargassum_Fusiform_Polysaccharides.

27 

Chu H-L, Mao H, Feng W, Liu JW and Geng Y: Effects of sulfated polysaccharide from Masson pine (Pinus massoniana) pollen on the proliferation and cell cycle of HepG2 cells. Int J Biol Macromol. 55:104–108. 2013. View Article : Google Scholar

28 

Mao F, Xiao B, Jiang Z, Zhao J, Huang X and Guo J: Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0/G1 phase arrest. Med Oncol. 28:121–126. 2011. View Article : Google Scholar

29 

Cao Y, Ruan Y, Shen T, Huang X, Li M, Yu W, Zhu Y, Man Y, Wang S and Li J: Astragalus polysaccharide suppresses doxorubicin-induced cardiotoxicity by regulating the PI3k/Akt and p38MAPK pathways. Oxid Med Cell Longev. 2014:6742192014. View Article : Google Scholar : PubMed/NCBI

30 

Chen J, Jin X, Chen J and Liu C: Glycyrrhiza polysaccharide induces apoptosis and inhibits proliferation of human hepatocellular carcinoma cells by blocking PI3K/AKT signal pathway. Tumour Biol. 34:1381–1389. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Xie X, Zou G and Li C: Antitumor and immunomodulatory activities of a water-soluble polysaccharide from Chaenomeles speciosa. Carbohydr Polym. 132:323–329. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Bao XL, Yuan HH, Wang CZ, Fan W and Lan MB: Polysaccharides from Cymbopogon citratus with antitumor and immunomodulatory activity. Pharm Biol. 53:117–124. 2015. View Article : Google Scholar

33 

Wakabayashi T, Hirokawa S, Yamauchi N, Kataoka T, Woo JT and Nagai K: Immunomodulating activities of polysaccharide fractions from dried safflower petals. Cytotechnology. 25:205–211. 1997. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Yu J, Du X, Zhang H, Wang B, Guo H, Bai J, Wang J, Liu A, Wang Y, Wang Y, et al: Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway. Oncol Rep 36: 147-154, 2016.
APA
Li, J., Yu, J., Du, X., Zhang, H., Wang, B., Guo, H. ... Wang, Y. (2016). Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway. Oncology Reports, 36, 147-154. https://doi.org/10.3892/or.2016.4784
MLA
Li, J., Yu, J., Du, X., Zhang, H., Wang, B., Guo, H., Bai, J., Wang, J., Liu, A., Wang, Y."Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway". Oncology Reports 36.1 (2016): 147-154.
Chicago
Li, J., Yu, J., Du, X., Zhang, H., Wang, B., Guo, H., Bai, J., Wang, J., Liu, A., Wang, Y."Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway". Oncology Reports 36, no. 1 (2016): 147-154. https://doi.org/10.3892/or.2016.4784
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Yu J, Du X, Zhang H, Wang B, Guo H, Bai J, Wang J, Liu A, Wang Y, Wang Y, et al: Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway. Oncol Rep 36: 147-154, 2016.
APA
Li, J., Yu, J., Du, X., Zhang, H., Wang, B., Guo, H. ... Wang, Y. (2016). Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway. Oncology Reports, 36, 147-154. https://doi.org/10.3892/or.2016.4784
MLA
Li, J., Yu, J., Du, X., Zhang, H., Wang, B., Guo, H., Bai, J., Wang, J., Liu, A., Wang, Y."Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway". Oncology Reports 36.1 (2016): 147-154.
Chicago
Li, J., Yu, J., Du, X., Zhang, H., Wang, B., Guo, H., Bai, J., Wang, J., Liu, A., Wang, Y."Safflower polysaccharide induces NSCLC cell apoptosis by inhibition of the Akt pathway". Oncology Reports 36, no. 1 (2016): 147-154. https://doi.org/10.3892/or.2016.4784
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