T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12

  • Authors:
    • Zongmiao Wan
    • Dongjie Jiang
    • Su Chen
    • Jian Jiao
    • Lei Ji
    • Abdus Saboor Shah
    • Haifeng Wei
    • Xinghai Yang
    • Xiaotao Li
    • Ying Wang
    • Jianru Xiao
  • View Affiliations

  • Published online on: May 9, 2016     https://doi.org/10.3892/or.2016.4792
  • Pages: 306-314
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Abstract

T-box transcription factor brachyury and matrix metalloproteinases (MMPs) play important roles in non-small cell lung cancer (NSCLC) cell invasion and metastasis. However, the association between Brachyury and the MMP family has not yet been fully investigated. The present study aimed to assess the influence of Brachyury on the expression of 23 MMP members and to further explore the mechanisms involved in the promotion of NSCLC cell invasion by Brachyury and MMPs in the H460 and H1299 stable cell lines. The protein expression levels and correlations between the brachyury transcription factor and the targeted MMPs were also validated in 52 NSCLC patient tissue samples. We observed that brachyury significantly upregulated MMP12 expression to promote NSCLC cell invasion. We also found a potential binding site for the brachyury transcription factor in the MMP12 promoter.
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July-2016
Volume 36 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Wan Z, Jiang D, Chen S, Jiao J, Ji L, Shah AS, Wei H, Yang X, Li X, Wang Y, Wang Y, et al: T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12. Oncol Rep 36: 306-314, 2016
APA
Wan, Z., Jiang, D., Chen, S., Jiao, J., Ji, L., Shah, A.S. ... Xiao, J. (2016). T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12. Oncology Reports, 36, 306-314. https://doi.org/10.3892/or.2016.4792
MLA
Wan, Z., Jiang, D., Chen, S., Jiao, J., Ji, L., Shah, A. S., Wei, H., Yang, X., Li, X., Wang, Y., Xiao, J."T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12". Oncology Reports 36.1 (2016): 306-314.
Chicago
Wan, Z., Jiang, D., Chen, S., Jiao, J., Ji, L., Shah, A. S., Wei, H., Yang, X., Li, X., Wang, Y., Xiao, J."T-box transcription factor brachyury promotes tumor cell invasion and metastasis in non-small cell lung cancer via upregulation of matrix metalloproteinase 12". Oncology Reports 36, no. 1 (2016): 306-314. https://doi.org/10.3892/or.2016.4792