Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer

  • Authors:
    • Ruirui Yang
    • Ying Zeng
    • Haifan Xu
    • Zhuo Chen
    • Mengqin Xiang
    • Yun Fu
    • Yufang Yin
    • Jing Zhong
    • Min Zeng
    • Peihua Wang
    • Qin You
    • Xi Zeng
  • View Affiliations

  • Published online on: June 2, 2016     https://doi.org/10.3892/or.2016.4845
  • Pages: 929-935
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is one of the major pre-mRNA-binding proteins, that is involved in translational modifications. In our previous studies, we found that hnRNP K is associated with human gastric cancer. The protein levels of hnRNP K were detected in cell lines and tissue microarrays. The correlation between hnRNP K expression and patient survival rate was evaluated by Kaplan-Meier survival analysis. In addition, we also detected hnRNP K expression in preoperative and postoperative serum samples from patients with gastric cancer, and serum samples from healthy volunteers. We found that hnRNP K was overexpressed in the gastric cancer cell lines. The levels of hnRNP K were significantly elevated in the gastric cancer tissues compared with that noted in the tumor-adjacent gastric mucosal and normal gastric mucosal sampes, and hnRNP K expression was found to correlate with tumor stage and lymph node metastasis. However, the level of serum hnRNP K did not differ significantly between gastric cancer patients and healthy volunteers. We also found that patients whose tumors showed elevated expression of hnRNP K had poor survival. The present study suggests that hnRNP K is a promising tissue biomarker for diagnosing gastric cancer and is a prognostic indicator for patients with gastric cancer.
View Figures
View References

Related Articles

Journal Cover

August-2016
Volume 36 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang R, Zeng Y, Xu H, Chen Z, Xiang M, Fu Y, Yin Y, Zhong J, Zeng M, Wang P, Wang P, et al: Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer. Oncol Rep 36: 929-935, 2016.
APA
Yang, R., Zeng, Y., Xu, H., Chen, Z., Xiang, M., Fu, Y. ... Zeng, X. (2016). Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer. Oncology Reports, 36, 929-935. https://doi.org/10.3892/or.2016.4845
MLA
Yang, R., Zeng, Y., Xu, H., Chen, Z., Xiang, M., Fu, Y., Yin, Y., Zhong, J., Zeng, M., Wang, P., You, Q., Zeng, X."Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer". Oncology Reports 36.2 (2016): 929-935.
Chicago
Yang, R., Zeng, Y., Xu, H., Chen, Z., Xiang, M., Fu, Y., Yin, Y., Zhong, J., Zeng, M., Wang, P., You, Q., Zeng, X."Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer". Oncology Reports 36, no. 2 (2016): 929-935. https://doi.org/10.3892/or.2016.4845