Angiotensin II promotes endometrial cancer cell survival

  • Authors:
    • Magdalena Nowakowska
    • Zuzanna Matysiak-Burzyńska
    • Karolina Kowalska
    • Elżbieta Płuciennik
    • Kamila Domińska
    • Agnieszka W. Piastowska-Ciesielska
  • View Affiliations

  • Published online on: June 21, 2016     https://doi.org/10.3892/or.2016.4887
  • Pages: 1101-1110
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Abstract

Endometrial cancer (EC) is one of the most common female cancers. One of the key processes involved in EC development is uncontrolled proliferation stimulated by local factors such as angiotensin. The aim of the present study was to evaluate the influence of angiotensin II (Ang II) on human EC cells. Biological assays and gene expression analysis were performed on three cell lines: ISH, MFE-296 and MFE-280. Our results indicated that at the beginning of cancerogenesis Ang II induced abnormal proliferation at lower doses. We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation.
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August-2016
Volume 36 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Nowakowska M, Matysiak-Burzyńska Z, Kowalska K, Płuciennik E, Domińska K and Piastowska-Ciesielska AW: Angiotensin II promotes endometrial cancer cell survival. Oncol Rep 36: 1101-1110, 2016
APA
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., & Piastowska-Ciesielska, A.W. (2016). Angiotensin II promotes endometrial cancer cell survival. Oncology Reports, 36, 1101-1110. https://doi.org/10.3892/or.2016.4887
MLA
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., Piastowska-Ciesielska, A. W."Angiotensin II promotes endometrial cancer cell survival". Oncology Reports 36.2 (2016): 1101-1110.
Chicago
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., Piastowska-Ciesielska, A. W."Angiotensin II promotes endometrial cancer cell survival". Oncology Reports 36, no. 2 (2016): 1101-1110. https://doi.org/10.3892/or.2016.4887