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Article

Angiotensin II promotes endometrial cancer cell survival

  • Authors:
    • Magdalena Nowakowska
    • Zuzanna Matysiak-Burzyńska
    • Karolina Kowalska
    • Elżbieta Płuciennik
    • Kamila Domińska
    • Agnieszka W. Piastowska-Ciesielska
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Carcinogenesis, Medical University of Lodz, Lodz 90-752, Poland, Department of Comparative Endocrinology, Medical University of Lodz, Lodz 90-752, Poland
  • Pages: 1101-1110
    |
    Published online on: June 21, 2016
       https://doi.org/10.3892/or.2016.4887
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Abstract

Endometrial cancer (EC) is one of the most common female cancers. One of the key processes involved in EC development is uncontrolled proliferation stimulated by local factors such as angiotensin. The aim of the present study was to evaluate the influence of angiotensin II (Ang II) on human EC cells. Biological assays and gene expression analysis were performed on three cell lines: ISH, MFE-296 and MFE-280. Our results indicated that at the beginning of cancerogenesis Ang II induced abnormal proliferation at lower doses. We also showed that dose-dependent induction of proliferation was connected with changes in the expression of MKI67, CCND1 and CCNE1 genes in well- and poorly differentiated cancer cells. After Ang II treatment, poorly differentiated endometrial cancer cell line acquired a mesenchymal phenotype, which was characterized by induced expression of EMT-related genes (VIM, CD44, SNAI1, ZEB1 and ZEB2). Our study revealed that Ang II influences EC cells in terms of cancer-related processes, and is responsible for increased proliferation, reduction in apoptosis, increased mobility and modulation of adhesion potential. Its effect and effectiveness appear to be highly connected with the differentiation status of the cancerous cells, as Ang II appears to play a crucial role in the early and late stages of malignant transformation.
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View References

1 

Wojciechowska U and Didkowska J: Illness and deaths from malignant tumors in Poland. National Cancer Registry, Cancer Centre. Institute for them. Maria Sklodowska - Curie. ISSN: 0867-8251http://onkologia.org.pl/wp-content/uploads/BIUL2013.pdf.

2 

Piastowska-Ciesielska AW, Płuciennik E, Wójcik-Krowiranda K, Bieńkiewicz A, Bednarek A and Ochędalski T: Analysis of the expression of angiotensin II type 1 receptor and VEGF in endometrial adenocarcinoma with different clinicopathological characteristics. Tumour Biol. 33:767–774. 2012. View Article : Google Scholar

3 

Matysiak ZE, Ochędalski T and Piastowska-Ciesielska AW: The evaluation of involvement of angiotensin II, its receptors, and androgen receptor in endometrial cancer. Gynecol Endocrinol. 31:1–6. 2015. View Article : Google Scholar

4 

Rodrigues-Ferreira S, Abdelkarim M, Dillenburg-Pilla P, Luissint AC, di-Tommaso A, Deshayes F, Pontes CL, Molina A, Cagnard N, Letourneur F, et al: Angiotensin II facilitates breast cancer cell migration and metastasis. PloS One. 7:e356672012. View Article : Google Scholar : PubMed/NCBI

5 

Deshayes F and Nahmias C: Angiotensin receptors: A new role in cancer? Trends Endocrinol Metab. 16:293–299. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Shan T, Zhang L, Zhao C, Chen W, Zhang Y and Li G: Angiotensin-(1–7) and angiotensin II induce the transdifferentiation of human endometrial epithelial cells in vitro. Mol Med Rep. 9:2180–2186. 2014.PubMed/NCBI

7 

Yin T, Ma X, Zhao L, Cheng K and Wang H: Angiotensin II promotes NO production, inhibits apoptosis and enhances adhesion potential of bone marrow-derived endothelial progenitor cells. Cell Res. 18:792–799. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Tokinaga Y, Kimoto Y, Ogawa K, Mizumoto K, Tange K and Hatano Y: Reduction of adhesion formation by an angiotensin type 1 receptor antagonist. Langenbecks Arch Surg. 396:127–132. 2011. View Article : Google Scholar

9 

Domińska K, Piastowska-Ciesielska AW, Lachowicz-Ochędalska A and Ochędalski T: Similarities and differences between effects of angiotensin III and angiotensin II on human prostate cancer cell migration and proliferation. Peptides. 37:200–206. 2012. View Article : Google Scholar

10 

Piastowska-Ciesielska AW, Domińska K, Nowakowska M, Gajewska M, Gajos-Michniewicz A and Ochędalski T: Angiotensin modulates human mammary epithelial cell motility. J Renin Angiotensin Aldosterone Syst. 15:419–429. 2014. View Article : Google Scholar

11 

Zhao Y, Wang H, Li X, Cao M, Lu H, Meng Q, Pang H, Li H, Nadolny C, Dong X, et al: Ang II-AT1R increases cell migration through PI3K/AKT and NF-κB pathways in breast cancer. J Cell Physiol. 229:1855–1862. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Zhao Y, Chen X, Cai L, Yang Y, Sui G and Fu S: Angiotensin II/angiotensin II type I receptor (AT1R) signaling promotes MCF-7 breast cancer cells survival via PI3-kinase/Akt pathway. J Cell Physiol. 225:168–173. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Uemura H, Ishiguro H, Nakaigawa N, Nagashima Y, Miyoshi Y, Fujinami K, Sakaguchi A and Kubota Y: Angiotensin II receptor blocker shows antiproliferative activity in prostate cancer cells: A possibility of tyrosine kinase inhibitor of growth factor. Mol Cancer Ther. 2:1139–1147. 2003.PubMed/NCBI

14 

De Paepe B, Verstraeten VM, De Potter CR and Bullock GR: Increased angiotensin II type-2 receptor density in hyperplasia, DCIS and invasive carcinoma of the breast is paralleled with increased iNOS expression. Histochem Cell Biol. 117:13–19. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Guo R, Gu J, Zhang Z, Wang Y and Gu C: MicroRNA-410 functions as a tumor suppressor by targeting angiotensin II type 1 receptor in pancreatic cancer. IUBMB life. 67:42–53. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Kinoshita J, Fushida S, Harada S, Yagi Y, Fujita H, Kinami S, Ninomiya I, Fujimura T, Kayahara M, Yashiro M, et al: Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERk1/2, NF-κB and survivin. Int J Oncol. 34:1573–1582. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Mohammad RM, Muqbil I, Lowe L, Yedjou C, Hsu HY, Lin LT, Siegelin MD, Fimognari C, Kumar NB, Dou QP, et al: Broad targeting of resistance to apoptosis in cancer. Semin Cancer Biol. 35(Suppl): S78–S103. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zhao Y, Chen X, Cai L, Yang Y, Sui G and Wu J: Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells. Acta Biochim Biophys Sin (Shanghai). 40:304–310. 2008. View Article : Google Scholar

19 

Wolf G and Wenzel UO: Angiotensin II and cell cycle regulation. Hypertension. 43:693–698. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Zapiecki K, Manahan KJ, Miller GA and Geisler JP: Cyclin E is overexpressed by clear cell carcinomas of the endometrium and is a prognostic indicator of survival. Eur J Gynaecol Oncol. 36:114–116. 2015.PubMed/NCBI

21 

Shevra CR, Ghosh A and Kumar M: Cyclin D1 and KI-67 expression in normal, hyperplastic and neoplastic endometrium. J Postgrad Med. 61:15–20. 2015. View Article : Google Scholar

22 

Okegawa T, Pong RC, Li Y and Hsieh JT: The role of cell adhesion molecule in cancer progression and its application in cancer therapy. Acta Biochim Pol. 51:445–457. 2004.PubMed/NCBI

23 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Takeda H, Katagata Y, Hozumi Y and Kondo S: Effects of angiotensin II receptor signaling during skin wound healing. Am J Pathol. 165:1653–1662. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Sakai H, Matsuura K, Tanaka Y, Honda T, Nishida T and Inui M: Signaling mechanism underlying the promotion of keratinocyte migration by angiotensin II. Mol Pharmacol. 87:277–285. 2015. View Article : Google Scholar

26 

Liu Y, Tian X, Cui M and Zhao S: Safflower yellow inhibits angiotensin II-induced adventitial fibroblast proliferation and migration. J Pharmacol Sci. 126:107–114. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Puddefoot JR, Udeozo UK, Barker S and Vinson GP: The role of angiotensin II in the regulation of breast cancer cell adhesion and invasion. Endocr Relat Cancer. 13:895–903. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Bokhari AA and Syed V: Inhibition of transforming growth factor-β (TGF-β) signaling by Scutellaria baicalensis and Fritillaria cirrhosa extracts in endometrial cancer. J Cell Biochem. 116:1797–1805. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Piestrzeniewicz-Ulanska D, Brys M, Semczuk A, Rechberger T, Jakowicki JA and Krajewska WM: TGF-β signaling is disrupted in endometrioid-type endometrial carcinomas. Gynecol Oncol. 95:173–180. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Saad S, Stanners SR, Yong R, Tang O and Pollock CA: Notch mediated epithelial to mesenchymal transformation is associated with increased expression of the Snail transcription factor. Int J Biochem Cell Biol. 42:1115–1122. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Okazaki M, Fushida S, Harada S, Tsukada T, Kinoshita J, Oyama K, Tajima H, Ninomiya I, Fujimura T and Ohta T: The angiotensin II type 1 receptor blocker candesartan suppresses proliferation and fibrosis in gastric cancer. Cancer Lett. 355:46–53. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Qian YR, Guo Y, Wan HY, Fan L, Feng Y, Ni L, Xiang Y and Li QY: Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition. Oncol Rep. 29:2408–2414. 2013.PubMed/NCBI

33 

Okamoto K, Tajima H, Nakanuma S, Sakai S, Makino I, Kinoshita J, Hayashi H, Nakamura K, Oyama K, Nakagawara H, et al: Angiotensin II enhances epithelial-to-mesenchymal transition through the interaction between activated hepatic stellate cells and the stromal cell-derived factor-1/CXCR4 axis in intrahepatic cholangiocarcinoma. Int J Oncol. 41:573–582. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Nowakowska M, Matysiak-Burzyńska Z, Kowalska K, Płuciennik E, Domińska K and Piastowska-Ciesielska AW: Angiotensin II promotes endometrial cancer cell survival. Oncol Rep 36: 1101-1110, 2016.
APA
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., & Piastowska-Ciesielska, A.W. (2016). Angiotensin II promotes endometrial cancer cell survival. Oncology Reports, 36, 1101-1110. https://doi.org/10.3892/or.2016.4887
MLA
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., Piastowska-Ciesielska, A. W."Angiotensin II promotes endometrial cancer cell survival". Oncology Reports 36.2 (2016): 1101-1110.
Chicago
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., Piastowska-Ciesielska, A. W."Angiotensin II promotes endometrial cancer cell survival". Oncology Reports 36, no. 2 (2016): 1101-1110. https://doi.org/10.3892/or.2016.4887
Copy and paste a formatted citation
x
Spandidos Publications style
Nowakowska M, Matysiak-Burzyńska Z, Kowalska K, Płuciennik E, Domińska K and Piastowska-Ciesielska AW: Angiotensin II promotes endometrial cancer cell survival. Oncol Rep 36: 1101-1110, 2016.
APA
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., & Piastowska-Ciesielska, A.W. (2016). Angiotensin II promotes endometrial cancer cell survival. Oncology Reports, 36, 1101-1110. https://doi.org/10.3892/or.2016.4887
MLA
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., Piastowska-Ciesielska, A. W."Angiotensin II promotes endometrial cancer cell survival". Oncology Reports 36.2 (2016): 1101-1110.
Chicago
Nowakowska, M., Matysiak-Burzyńska, Z., Kowalska, K., Płuciennik, E., Domińska, K., Piastowska-Ciesielska, A. W."Angiotensin II promotes endometrial cancer cell survival". Oncology Reports 36, no. 2 (2016): 1101-1110. https://doi.org/10.3892/or.2016.4887
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