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Article

miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7

  • Authors:
    • Jingzhu Zhao
    • Chuanxiang Hu
    • Jiadong Chi
    • Jiansen Li
    • Chen Peng
    • Xinwei Yun
    • Dapeng Li
    • Yang Yu
    • Yigong Li
    • Ming Gao
    • Xiangqian Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin National Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin National Clinical Research Center for Cancer, Tianjin 300060, P.R. China
  • Pages: 1143-1149
    |
    Published online on: June 22, 2016
       https://doi.org/10.3892/or.2016.4891
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Abstract

Recent studies suggest that aberrant expression of miR-24 is linked to various human cancers, including tongue squamous cell carcinoma (TSCC). F-box and WD-40 domain protein 7 (FBXW7), a tumor-suppressor gene, is responsible for the degradation of several proto-oncogenes. However, the function and mechanism of miR-24 and FBXW7 in TSCC remains unclear. In the present study, we found that miR-24 was increased in TSCC tissues and cell lines, and that upregulation of miR-24 was associated with advanced clinical stage and a shorter overall survival of TSCC patients. Inhibition of miR-24 significantly suppressed the proliferation, migration and invasion of TSCC cells in vitro. Furthermore, miR-24 repressed FBXW7 expression by directly binding to the 3-untranslated region of FBXW7. Moreover, the suppression of FBXW7 increased the proliferation, migration and invasion of TSCC cells, and the restoration of FBXW7 substantially attenuated the oncogenic effects of miR-24. In conclusion, our results demonstrated that upregulation of miR-24 was associated with tumor progression and poor prognosis in TSCC patients, and that overexpression of miR-24 was correlated with the proliferation, migration and invasion of TSCC cells in vitro, at least partially through regulation of its functional target FBXW7. Thus, miR-24 may serve as a novel potential biomarker for the prognosis of TSCC patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Hu C, Chi J, Li J, Peng C, Yun X, Li D, Yu Y, Li Y, Gao M, Gao M, et al: miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7. Oncol Rep 36: 1143-1149, 2016.
APA
Zhao, J., Hu, C., Chi, J., Li, J., Peng, C., Yun, X. ... Zheng, X. (2016). miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7. Oncology Reports, 36, 1143-1149. https://doi.org/10.3892/or.2016.4891
MLA
Zhao, J., Hu, C., Chi, J., Li, J., Peng, C., Yun, X., Li, D., Yu, Y., Li, Y., Gao, M., Zheng, X."miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7". Oncology Reports 36.2 (2016): 1143-1149.
Chicago
Zhao, J., Hu, C., Chi, J., Li, J., Peng, C., Yun, X., Li, D., Yu, Y., Li, Y., Gao, M., Zheng, X."miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7". Oncology Reports 36, no. 2 (2016): 1143-1149. https://doi.org/10.3892/or.2016.4891
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Hu C, Chi J, Li J, Peng C, Yun X, Li D, Yu Y, Li Y, Gao M, Gao M, et al: miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7. Oncol Rep 36: 1143-1149, 2016.
APA
Zhao, J., Hu, C., Chi, J., Li, J., Peng, C., Yun, X. ... Zheng, X. (2016). miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7. Oncology Reports, 36, 1143-1149. https://doi.org/10.3892/or.2016.4891
MLA
Zhao, J., Hu, C., Chi, J., Li, J., Peng, C., Yun, X., Li, D., Yu, Y., Li, Y., Gao, M., Zheng, X."miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7". Oncology Reports 36.2 (2016): 1143-1149.
Chicago
Zhao, J., Hu, C., Chi, J., Li, J., Peng, C., Yun, X., Li, D., Yu, Y., Li, Y., Gao, M., Zheng, X."miR-24 promotes the proliferation, migration and invasion in human tongue squamous cell carcinoma by targeting FBXW7". Oncology Reports 36, no. 2 (2016): 1143-1149. https://doi.org/10.3892/or.2016.4891
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