Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)

  • Authors:
    • Meng Xie
    • Dafydd Alwyn Dart
    • Sioned Owen
    • Xianzi Wen
    • Jiafu Ji
    • Wenguo Jiang
  • View Affiliations

  • Published online on: June 27, 2016     https://doi.org/10.3892/or.2016.4908
  • Pages: 1191-1198
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Gastric cancer (GC) remains the third most common cause of cancer deaths worldwide and carries a high rate of metastatic risk contributing to the main cause of treatment failure. An accumulation of data has resulted in a better understanding of the molecular network of GC, however, gaps still exist between the unique bio-resources and clinical application. MicroRNAs are an important part of non-coding RNAs and behave as major regulators of tumour biology, alongside their well-known roles as intrinsic factors of gene expression in cellular processes, via their post-transcriptional regulation of components of signalling pathways in a coordinated manner. Deregulation of the miR-1, -133 and -206 family plays a key role in tumorigenesis, progression, invasion and metastasis. This review aims to provide a summary of recent findings on the miR-1, -133 and -206 family in GC and how this knowledge might be exploited for the development of future miRNA-based therapies for the treatment of GC.
View Figures
View References

Related Articles

Journal Cover

September-2016
Volume 36 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xie M, Dart DA, Owen S, Wen X, Ji J and Jiang W: Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review). Oncol Rep 36: 1191-1198, 2016
APA
Xie, M., Dart, D.A., Owen, S., Wen, X., Ji, J., & Jiang, W. (2016). Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review). Oncology Reports, 36, 1191-1198. https://doi.org/10.3892/or.2016.4908
MLA
Xie, M., Dart, D. A., Owen, S., Wen, X., Ji, J., Jiang, W."Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)". Oncology Reports 36.3 (2016): 1191-1198.
Chicago
Xie, M., Dart, D. A., Owen, S., Wen, X., Ji, J., Jiang, W."Insights into roles of the miR-1, -133 and -206 family in gastric cancer (Review)". Oncology Reports 36, no. 3 (2016): 1191-1198. https://doi.org/10.3892/or.2016.4908