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Review

The biological role of epithelial-mesenchymal transition in lung cancer (Review)

  • Authors:
    • Woo Jung Sung
    • Hongtae Kim
    • Kwan-Kyu Park
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Catholic University of Daegu College of Medicine, Nam-gu, Daegu 42472, Republic of Korea, Department of Anatomy, Catholic University of Daegu College of Medicine, Nam-gu, Daegu 42472, Republic of Korea
  • Pages: 1199-1206
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    Published online on: July 21, 2016
       https://doi.org/10.3892/or.2016.4964
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Abstract

Epithelial-mesenchymal transition (EMT) is a process whereby epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders and fibrotic tissue remodeling to lung cancer. Lung cancer is the most lethal form of cancer worldwide, and despite significant therapeutic improvements, the patient survival rate still remains low. Activation of EMT endows invasive and metastatic properties upon cancer cells that favor successful colonization of distal target organs. The present review provides a brief insight into the mechanism and biological assessment methods of EMT in lung cancer and summarizes the recent literature highlighting the controversial experimental data and conclusions.
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Copy and paste a formatted citation
Spandidos Publications style
Sung WJ, Kim H and Park K: The biological role of epithelial-mesenchymal transition in lung cancer (Review). Oncol Rep 36: 1199-1206, 2016.
APA
Sung, W.J., Kim, H., & Park, K. (2016). The biological role of epithelial-mesenchymal transition in lung cancer (Review). Oncology Reports, 36, 1199-1206. https://doi.org/10.3892/or.2016.4964
MLA
Sung, W. J., Kim, H., Park, K."The biological role of epithelial-mesenchymal transition in lung cancer (Review)". Oncology Reports 36.3 (2016): 1199-1206.
Chicago
Sung, W. J., Kim, H., Park, K."The biological role of epithelial-mesenchymal transition in lung cancer (Review)". Oncology Reports 36, no. 3 (2016): 1199-1206. https://doi.org/10.3892/or.2016.4964
Copy and paste a formatted citation
x
Spandidos Publications style
Sung WJ, Kim H and Park K: The biological role of epithelial-mesenchymal transition in lung cancer (Review). Oncol Rep 36: 1199-1206, 2016.
APA
Sung, W.J., Kim, H., & Park, K. (2016). The biological role of epithelial-mesenchymal transition in lung cancer (Review). Oncology Reports, 36, 1199-1206. https://doi.org/10.3892/or.2016.4964
MLA
Sung, W. J., Kim, H., Park, K."The biological role of epithelial-mesenchymal transition in lung cancer (Review)". Oncology Reports 36.3 (2016): 1199-1206.
Chicago
Sung, W. J., Kim, H., Park, K."The biological role of epithelial-mesenchymal transition in lung cancer (Review)". Oncology Reports 36, no. 3 (2016): 1199-1206. https://doi.org/10.3892/or.2016.4964
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