Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways

  • Authors:
    • Ailin Yang
    • Haitao Fan
    • Yunfang Zhao
    • Xiaojun Zha
    • Hongbing Zhang
    • Zhongdong Hu
    • Pengfei Tu
  • View Affiliations

  • Published online on: July 25, 2016     https://doi.org/10.3892/or.2016.4969
  • Pages: 1491-1498
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Tuberous sclerosis complex (TSC) is a genetic disorder with formation of benign tumors in many different organs. It has attracted increasing attention from researchers to search for therapeutic drugs for TSC patients. Traditional Chinese medicine (TCM) has become an important source for finding antitumor drugs. Trametes robiniophila Μurr. (Huaier) is a kind of officinal fungi in China and has been applied in TCM for approximately 1,600 years. A large number of clinical applications have revealed that Huaier has good antitumor effect. In this study, we have investigated the effects of Huaier aqueous extract on two TSC cell models, including inhibition of proliferation, induction of apoptosis, cell cycle arrest, and anti-metastasis. We demonstrated that Huaier aqueous extract inhibited JAK2/STAT3 and MAPK signaling pathways in a dose-dependent manner. Therefore, based on the low toxicity and the multi-targets of Huaier treatment, Huaier may be a promising therapeutic drug for TSC.
View Figures
View References

Related Articles

Journal Cover

September-2016
Volume 36 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang A, Fan H, Zhao Y, Zha X, Zhang H, Hu Z and Tu P: Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways. Oncol Rep 36: 1491-1498, 2016.
APA
Yang, A., Fan, H., Zhao, Y., Zha, X., Zhang, H., Hu, Z., & Tu, P. (2016). Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways. Oncology Reports, 36, 1491-1498. https://doi.org/10.3892/or.2016.4969
MLA
Yang, A., Fan, H., Zhao, Y., Zha, X., Zhang, H., Hu, Z., Tu, P."Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways". Oncology Reports 36.3 (2016): 1491-1498.
Chicago
Yang, A., Fan, H., Zhao, Y., Zha, X., Zhang, H., Hu, Z., Tu, P."Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways". Oncology Reports 36, no. 3 (2016): 1491-1498. https://doi.org/10.3892/or.2016.4969