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Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review)

  • Authors:
    • Dragana Nikitovic
    • Rafaela‑Maria Kavasi
    • Aikaterini Berdiaki
    • Dionysios J. Papachristou
    • John Tsiaoussis
    • Demetrios A. Spandidos
    • Aristides M. Tsatsakis
    • George N. Tzanakakis
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy‑Histology‑Embryology, School of Medicine, University of Crete, Heraklion 71003, Greece, Department of Anatomy‑Histology‑Embryology, Unit of Bone and Soft Tissue Studies, School of Medicine, University of Patras, Patras 26504, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, Heraklion 71003, Greece, Laboratory of Toxicology, Medical School, University of Crete, Heraklion 71003, Greece
    Copyright: © Nikitovic et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1787-1792
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    Published online on: August 1, 2016
       https://doi.org/10.3892/or.2016.4986
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Abstract

Osteosarcoma (OS) is a primary bone tumor of mesenchymal origin mostly affecting children and adolescents. The OS extracellular matrix (ECM) is extensively altered as compared to physiological bone tissue. Indeed, the main characteristic of the most common osteoblastic subtype of OS is non‑mineralized osteoid production. Parathyroid hormone (PTH) is a polypeptide hormone secreted by the chief cells of the parathyroid glands. The PTH-related peptide (PTHrP) may be comprised of 139, 141 or 173 amino acids and exhibits considerate N‑terminal amino acid sequence homology with PTH. The function of PTH/PTHrP is executed through the activation of the PTH receptor 1 (PTHR1) and respective downstream intracellular pathways which regulate skeletal development, bone turnover and mineral ion homeostasis. Both PTHR1 and its PTH/PTHrP ligands have been shown to be expressed in OS and to affect the functions of these tumor cells. This review aims to highlight the less well known aspects of PTH/PTHrP functions in the progression of OS by focusing on ECM-dependent signaling.
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Copy and paste a formatted citation
Spandidos Publications style
Nikitovic D, Kavasi RM, Berdiaki A, Papachristou DJ, Tsiaoussis J, Spandidos DA, Tsatsakis AM and Tzanakakis GN: Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review). Oncol Rep 36: 1787-1792, 2016.
APA
Nikitovic, D., Kavasi, R., Berdiaki, A., Papachristou, D.J., Tsiaoussis, J., Spandidos, D.A. ... Tzanakakis, G.N. (2016). Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review). Oncology Reports, 36, 1787-1792. https://doi.org/10.3892/or.2016.4986
MLA
Nikitovic, D., Kavasi, R., Berdiaki, A., Papachristou, D. J., Tsiaoussis, J., Spandidos, D. A., Tsatsakis, A. M., Tzanakakis, G. N."Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review)". Oncology Reports 36.4 (2016): 1787-1792.
Chicago
Nikitovic, D., Kavasi, R., Berdiaki, A., Papachristou, D. J., Tsiaoussis, J., Spandidos, D. A., Tsatsakis, A. M., Tzanakakis, G. N."Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review)". Oncology Reports 36, no. 4 (2016): 1787-1792. https://doi.org/10.3892/or.2016.4986
Copy and paste a formatted citation
x
Spandidos Publications style
Nikitovic D, Kavasi RM, Berdiaki A, Papachristou DJ, Tsiaoussis J, Spandidos DA, Tsatsakis AM and Tzanakakis GN: Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review). Oncol Rep 36: 1787-1792, 2016.
APA
Nikitovic, D., Kavasi, R., Berdiaki, A., Papachristou, D.J., Tsiaoussis, J., Spandidos, D.A. ... Tzanakakis, G.N. (2016). Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review). Oncology Reports, 36, 1787-1792. https://doi.org/10.3892/or.2016.4986
MLA
Nikitovic, D., Kavasi, R., Berdiaki, A., Papachristou, D. J., Tsiaoussis, J., Spandidos, D. A., Tsatsakis, A. M., Tzanakakis, G. N."Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review)". Oncology Reports 36.4 (2016): 1787-1792.
Chicago
Nikitovic, D., Kavasi, R., Berdiaki, A., Papachristou, D. J., Tsiaoussis, J., Spandidos, D. A., Tsatsakis, A. M., Tzanakakis, G. N."Parathyroid hormone/parathyroid hormone-related peptide regulate osteosarcoma cell functions: Focus on the extracellular matrix (Review)". Oncology Reports 36, no. 4 (2016): 1787-1792. https://doi.org/10.3892/or.2016.4986
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