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Article

Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET

  • Authors:
    • Zhandong Zhang
    • Ye Kong
    • Wei Yang
    • Fei Ma
    • Yonglei Zhang
    • Sheqing Ji
    • Er-Min Ma
    • Hongxing Liu
    • Yongshun Chen
    • Yawei Hua
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China, Surgical Oncology, The People Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China, Department of Radiotherapy, Affiliated Tumor Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China
  • Pages: 2391-2397
    |
    Published online on: August 11, 2016
       https://doi.org/10.3892/or.2016.5016
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Abstract

Cisplatin (DDP) based chemotherapy is still the main strategy of human gastric cancer (GC) treatment. However, drug resistance is a major obstacle for DDP chemotherapy. Recent studies indicated that the resistance could be modulated by the regulation of dysregulated microRNAs (miRs). Previous study also found miR-34a was associated with cell proliferation and apoptosis in human GC; however, the relationship between miR-34a and DDP resistance still remains unexplored. The purpose of this study was to investigate whether miR-34a is associated with DDP resistance in human GC cells. Our study found that the expression of miR-34a was significantly decreased in DDP resistance human GC tissues and DDP resistance human GC SGC7901/DDP cells compared with normal GC tissues and cells. Upregulation of miR-34a enhanced the DDP sensitivity of SGC7901/DDP cells to DDP through the inhibition of cell proliferation and induction of cell apoptosis; on the other hand downregulation of miR-34a could weaken the DDP sensitivity of SGC7901 cells to DDP. Further study found that MET was a direct target of miR-34a and the regulation of MET could affect the DDP sensitivity of SGC7901/DDP cells. Moreover, our study also indicated that up­regulation of miR-34a could decrease the expression of MET in SGC7901/DDP cells. Therefore, our findings suggested miR-34a could modulate human gastric cancer cell DDP sensitivity by regulation of cell proliferation and apoptosis via targeting MET, potentially benefiting human GC treatment in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Kong Y, Yang W, Ma F, Zhang Y, Ji S, Ma E, Liu H, Chen Y, Hua Y, Hua Y, et al: Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET. Oncol Rep 36: 2391-2397, 2016.
APA
Zhang, Z., Kong, Y., Yang, W., Ma, F., Zhang, Y., Ji, S. ... Hua, Y. (2016). Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET. Oncology Reports, 36, 2391-2397. https://doi.org/10.3892/or.2016.5016
MLA
Zhang, Z., Kong, Y., Yang, W., Ma, F., Zhang, Y., Ji, S., Ma, E., Liu, H., Chen, Y., Hua, Y."Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET". Oncology Reports 36.4 (2016): 2391-2397.
Chicago
Zhang, Z., Kong, Y., Yang, W., Ma, F., Zhang, Y., Ji, S., Ma, E., Liu, H., Chen, Y., Hua, Y."Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET". Oncology Reports 36, no. 4 (2016): 2391-2397. https://doi.org/10.3892/or.2016.5016
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Kong Y, Yang W, Ma F, Zhang Y, Ji S, Ma E, Liu H, Chen Y, Hua Y, Hua Y, et al: Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET. Oncol Rep 36: 2391-2397, 2016.
APA
Zhang, Z., Kong, Y., Yang, W., Ma, F., Zhang, Y., Ji, S. ... Hua, Y. (2016). Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET. Oncology Reports, 36, 2391-2397. https://doi.org/10.3892/or.2016.5016
MLA
Zhang, Z., Kong, Y., Yang, W., Ma, F., Zhang, Y., Ji, S., Ma, E., Liu, H., Chen, Y., Hua, Y."Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET". Oncology Reports 36.4 (2016): 2391-2397.
Chicago
Zhang, Z., Kong, Y., Yang, W., Ma, F., Zhang, Y., Ji, S., Ma, E., Liu, H., Chen, Y., Hua, Y."Upregulation of microRNA-34a enhances the DDP sensitivity of gastric cancer cells by modulating proliferation and apoptosis via targeting MET". Oncology Reports 36, no. 4 (2016): 2391-2397. https://doi.org/10.3892/or.2016.5016
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