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Article

MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII

  • Authors:
    • Wei Zhang
    • Jianzhou Liu
    • Jianxin Qiu
    • Xiaoliang Fu
    • Qisheng Tang
    • Fan Yang
    • Zhiguang Zhao
    • He Wang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China, Department of Urology, Central Hospital of Baoji, Baoji, Shaanxi 721008, P.R. China
  • Pages: 3707-3715
    |
    Published online on: October 3, 2016
       https://doi.org/10.3892/or.2016.5141
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Abstract

MicroRNAs (miRNAs) have emerged as important regulators in cancer that are implicated in regulation of various cellular processes. miR-382 has been proposed as a tumor suppressor by several recent studies. However, the function of miR-382 in prostate cancer remains unknown. In this study, we aimed to investigate the potential function of miR-382 in prostate cancer. We found that miR-382 was significantly decreased in prostate cancer specimens and cancer cell lines. The overexpression of miR-382 in prostate cancer cells markedly inhibited cell proliferation, migration, and invasion. In contrast, miR-382 suppression exhibited an opposite effect. Target analysis predicted that chicken ovalbumin upstream promoter transcription factor II (COUP‑TFII) was a direct target of miR-382. This prediction was experimentally confirmed by dual-luciferase reporter assay, real-time quantitative polymerase chain reaction, and western blot analysis. Our results further demonstrated that miR-382 inhibited the downstream genes of COUP‑TFII, including Snail and matrix metalloproteinase 2 (MMP2). Moreover, the restoration of COUP‑TFII expression significantly blocked the inhibitory effect of miR-382 on cell proliferation, migration, and invasion, and Snail expression. Taken together, this study suggests that miR-382 inhibits prostate cancer cell proliferation and metastasis through inhibiting COUP‑TFII, representing an important new mechanism for understanding prostate cancer pathogenesis and providing a novel therapeutic candidate target for prostate cancer therapy.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Coleman RE: Clinical features of metastatic bone disease and risk of skeletal morbidity. Clin Cancer Res. 12:S6243–S6249. 2006. View Article : Google Scholar

3 

Mendell JT and Olson EN: MicroRNAs in stress signaling and human disease. Cell. 148:1172–1187. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Winter J, Jung S, Keller S, Gregory RI and Diederichs S: Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 11:228–234. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Esquela-Kerscher A and Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Cho WC: OncomiRs: The discovery and progress of microRNAs in cancers. Mol Cancer. 6:602007. View Article : Google Scholar : PubMed/NCBI

8 

Ranganathan K and Sivasankar V: MicroRNAs - Biology and clinical applications. J Oral Maxillofac Pathol. 18:229–234. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Wang YL, Wu S, Jiang B, Yin FF, Zheng SS and Hou SC: Role of microRNAs in prostate cancer pathogenesis. Clin Genitourin Cancer. 13:261–270. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ and O'Malley BW: COUP transcription factor is a member of the steroid receptor superfamily. Nature. 340:163–166. 1989. View Article : Google Scholar : PubMed/NCBI

11 

Tang K, Rubenstein JL, Tsai SY and Tsai MJ: COUP-TFII controls amygdala patterning by regulating neuropilin expression. Development. 139:1630–1639. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L, Tsai SY and Tsai MJ: The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 9:77–87. 2009. View Article : Google Scholar : PubMed/NCBI

13 

You LR, Lin FJ, Lee CT, DeMayo FJ, Tsai MJ and Tsai SY: Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature. 435:98–104. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Yu CT, Tang K, Suh JM, Jiang R, Tsai SY and Tsai MJ: COUP-TFII is essential for metanephric mesenchyme formation and kidney precursor cell survival. Development. 139:2330–2339. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Qin J, Chen X, Xie X, Tsai MJ and Tsai SY: COUP-TFII regulates tumor growth and metastasis by modulating tumor angiogenesis. Proc Natl Acad Sci USA. 107:3687–3692. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Qin J, Tsai SY and Tsai MJ: The critical roles of COUP-TFII in tumor progression and metastasis. Cell Biosci. 4:582014. View Article : Google Scholar : PubMed/NCBI

17 

Navab R, Gonzalez-Santos JM, Johnston MR, Liu J, Brodt P, Tsao MS and Hu J: Expression of chicken ovalbumin upstream promoter-transcription factor II enhances invasiveness of human lung carcinoma cells. Cancer Res. 64:5097–5105. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Bao Y, Gu D, Feng W, Sun X, Wang X, Zhang X, Shi Q, Cui G, Yu H, Tang C, et al: COUP-TFII regulates metastasis of colorectal adenocarcinoma cells by modulating Snail1. Br J Cancer. 111:933–943. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Polvani S, Tarocchi M, Tempesti S, Mello T, Ceni E, Buccoliero F, D'Amico M, Boddi V, Farsi M, Nesi S, et al: COUP-TFII in pancreatic adenocarcinoma: Clinical implication for patient survival and tumor progression. Int J Cancer. 134:1648–1658. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, et al: COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis. Nature. 493:236–240. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY and Tsai MJ: Dysregulation of miRNAs-COUP-TFII -FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 7:114182016. View Article : Google Scholar : PubMed/NCBI

22 

Zhou B, Song J, Han T, Huang M, Jiang H, Qiao H, Shi J and Wang Y: MiR-382 inhibits cell growth and invasion by targeting NR2F2 in colorectal cancer. Mol Carcinog. Jan 22–2016.(Epub ahead of print). doi: 10.1002/mc.22466. View Article : Google Scholar

23 

Tan H, He Q, Gong G, Wang Y, Li J, Wang J, Zhu D and Wu X: miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer. Int J Oncol. 48:181–190. 2016.PubMed/NCBI

24 

Qi B, Lu JG, Yao WJ, Chang TM, Qin XG, Ji YH, Wang TY, Liu SG, Li HC, Liu YZ, et al: Downregulation of microRNA-382 is associated with poor outcome of esophageal squamous cell carcinoma. World J Gastroenterol. 21:6884–6891. 2015.PubMed/NCBI

25 

Xu M, Jin H, Xu CX, Sun B, Mao Z, Bi WZ and Wang Y: miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma. Oncotarget. 5:9472–9483. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Thériault BL, Basavarajappa HD, Lim H, Pajovic S, Gallie BL and Corson TW: Transcriptional and epigenetic regulation of KIF14 overexpression in ovarian cancer. PLoS One. 9:e915402014. View Article : Google Scholar : PubMed/NCBI

27 

Xu M, Jin H, Xu CX, Sun B, Song ZG, Bi WZ and Wang Y: miR-382 inhibits osteosarcoma metastasis and relapse by targeting Y box-binding protein 1. Mol Ther. 23:89–98. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Hanniford D, Segura MF, Zhong J, Philips E, Jirau-Serrano X, Darvishian F, Berman RS, Shapiro RL, Pavlick AC, Brown B, et al: Identification of metastasis-suppressive microRNAs in primary melanoma. J Natl Cancer Inst. 107:1072015. View Article : Google Scholar

29 

Seok JK, Lee SH, Kim MJ and Lee YM: MicroRNA-382 induced by HIF-1α is an angiogenic miR targeting the tumor suppressor phosphatase and tensin homolog. Nucleic Acids Res. 42:8062–8072. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Bei Y, Song Y, Wang F, Dimitrova-Shumkovska J, Xiang Y, Zhao Y, Liu J, Xiao J and Yang C: miR-382 targeting PTEN-Akt axis promotes liver regeneration. Oncotarget. 7:1584–1597. 2016.PubMed/NCBI

31 

Nagasaki S, Suzuki T, Miki Y, Akahira J, Shibata H, Ishida T, Ohuchi N and Sasano H: Chicken ovalbumin upstream promoter transcription factor II in human breast carcinoma: Possible regulator of lymphangiogenesis via vascular endothelial growth factor-C expression. Cancer Sci. 100:639–645. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Shin SW, Kwon HC, Rho MS, Choi HJ, Kwak JY and Park JI: Clinical significance of chicken ovalbumin upstream promoter-transcription factor II expression in human colorectal cancer. Oncol Rep. 21:101–106. 2009.PubMed/NCBI

33 

Hawkins SM, Loomans HA, Wan YW, Ghosh-Choudhury T, Coffey D, Xiao W, Liu Z, Sangi-Haghpeykar H and Anderson ML: Expression and functional pathway analysis of nuclear receptor NR2F2 in ovarian cancer. J Clin Endocrinol Metab. 98:E1152–E1162. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Qin J, Tsai S and Tsai MJ: COUP-TFII, a prognostic marker and therapeutic target for prostate cancer. Asian J Androl. 15:360–361. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Kudo-Saito C, Shirako H, Takeuchi T and Kawakami Y: Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell. 15:195–206. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Song CH, Lee HJ, Park E and Lee K: The chicken ovalbumin upstream promoter-transcription factor II negatively regulates the transactivation of androgen receptor in prostate cancer cells. PLoS One. 7:e490262012. View Article : Google Scholar : PubMed/NCBI

37 

Litchfield LM, Appana SN, Datta S and Klinge CM: COUP-TFII inhibits NFkappaB activation in endocrine-resistant breast cancer cells. Mol Cell Endocrinol. 382:358–367. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Nakshatri H, Mendonca MS, Bhat-Nakshatri P, Patel NM, Goulet RJ Jr and Cornetta K: The orphan receptor COUP-TFII regulates G2/M progression of breast cancer cells by modulating the expression/activity of p21(WAF1/CIP1), cyclin D1, and cdk2. Biochem Biophys Res Commun. 270:1144–1153. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Rosa A and Brivanlou AH: A regulatory circuitry comprised of miR-302 and the transcription factors OCT4 and NR2F2 regulates human embryonic stem cell differentiation. EMBO J. 30:237–248. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Hu S, Wilson KD, Ghosh Z, Han L, Wang Y, Lan F, Ransohoff KJ, Burridge P and Wu JC: MicroRNA-302 increases reprogramming efficiency via repression of NR2F2. Stem Cells. 31:259–268. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Kang IH, Jeong BC, Hur SW, Choi H, Choi SH, Ryu JH, Hwang YC and Koh JT: MicroRNA-302a stimulates osteoblastic differentiation by repressing COUP-TFII expression. J Cell Physiol. 230:911–921. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Jeong BC, Kang IH, Hwang YC, Kim SH and Koh JT: MicroRNA-194 reciprocally stimulates osteogenesis and inhibits adipogenesis via regulating COUP-TFII expression. Cell Death Dis. 5:e15322014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Liu J, Qiu J, Fu X, Tang Q, Yang F, Zhao Z and Wang H: MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII . Oncol Rep 36: 3707-3715, 2016.
APA
Zhang, W., Liu, J., Qiu, J., Fu, X., Tang, Q., Yang, F. ... Wang, H. (2016). MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII . Oncology Reports, 36, 3707-3715. https://doi.org/10.3892/or.2016.5141
MLA
Zhang, W., Liu, J., Qiu, J., Fu, X., Tang, Q., Yang, F., Zhao, Z., Wang, H."MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII ". Oncology Reports 36.6 (2016): 3707-3715.
Chicago
Zhang, W., Liu, J., Qiu, J., Fu, X., Tang, Q., Yang, F., Zhao, Z., Wang, H."MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII ". Oncology Reports 36, no. 6 (2016): 3707-3715. https://doi.org/10.3892/or.2016.5141
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Liu J, Qiu J, Fu X, Tang Q, Yang F, Zhao Z and Wang H: MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII . Oncol Rep 36: 3707-3715, 2016.
APA
Zhang, W., Liu, J., Qiu, J., Fu, X., Tang, Q., Yang, F. ... Wang, H. (2016). MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII . Oncology Reports, 36, 3707-3715. https://doi.org/10.3892/or.2016.5141
MLA
Zhang, W., Liu, J., Qiu, J., Fu, X., Tang, Q., Yang, F., Zhao, Z., Wang, H."MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII ". Oncology Reports 36.6 (2016): 3707-3715.
Chicago
Zhang, W., Liu, J., Qiu, J., Fu, X., Tang, Q., Yang, F., Zhao, Z., Wang, H."MicroRNA-382 inhibits prostate cancer cell proliferation and metastasis through targeting COUP-TFII ". Oncology Reports 36, no. 6 (2016): 3707-3715. https://doi.org/10.3892/or.2016.5141
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