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Article

MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib

  • Authors:
    • A.L.R. Bordinhão
    • A.F. Evangelista
    • R.J.S. Oliveira
    • T. Macedo
    • H.C. Silveira
    • R.M. Reis
    • M.M. Marques
  • View Affiliations / Copyright

    Affiliations: Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil
  • Pages: 3197-3206
    |
    Published online on: October 7, 2016
       https://doi.org/10.3892/or.2016.5153
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Abstract

Cediranib, a pan-tyrosine kinase inhibitor is showing promising results for the treatment of several solid tumours. In breast cancer, its effects remain unclear, and there are no predictive biomarkers. Several studies have examined the expression profiles of microRNAs (miRNAs) in response to different chemotherapy treatments and found that the expression patterns may be associated with the treatment response. Therefore, our aim was to evaluate the cellular behaviour and differential expression profiles of miRNAs in breast cancer cell lines exposed to cediranib. The biological effect of this drug was measured by viability, migration, invasion and cell death in in vitro assays. Signaling pathways were assessed using a human phospho-receptor tyrosine kinase array. Furthermore, using a miRNA array and quantitative real-time PCR (qRT‑PCR), we assessed the relative expression of miRNAs following cediranib treatment. The breast cancer cell lines exhibited a distinct cytotoxic response to cediranib treatment. Cediranib exposure resulted in a decrease in the cell migration and invasion of all the breast cancer cell lines. Treatment with cediranib appeared to be able to modulate the activation of several RTKs that are targets of cediranib such as EGFR and a new potential target ROR2. Furthermore, this drug was able to modulate the expression profile of different microRNAs such as miR-494, miR-923, miR-449a, miR-449b and miR-886-3 in breast cancer cell lines. These miRNAs are reported to regulate genes involved in important molecular processes, according to bioinformatics prediction tools.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Lønning PE: Molecular basis for therapy resistance. Mol Oncol. 4:284–300. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Arpino G, Green SJ, Allred DC, Lew D, Martino S, Osborne CK and Elledge RM: HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: A southwest oncology group study. Clin Cancer Res. 10:5670–5676. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Wedge SR, Kendrew J, Hennequin LF, Valentine PJ, Barry ST, Brave SR, Smith NR, James NH, Dukes M, Curwen JO, et al: AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res. 65:4389–4400. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Brave SR, Ratcliffe K, Wilson Z, James NH, Ashton S, Wainwright A, Kendrew J, Dudley P, Broadbent N, Sproat G, et al: Assessing the activity of cediranib, a VEGFR-2/3 tyrosine kinase inhibitor, against VEGFR-1 and members of the structurally related PDGFR family. Mol Cancer Ther. 10:861–873. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Drevs J, Siegert P, Medinger M, Mross K, Strecker R, Zirrgiebel U, Harder J, Blum H, Robertson J, Jürgensmeier JM, et al: Phase I clinical study of AZD2171, an oral vascular endothelial growth factor signaling inhibitor, in patients with advanced solid tumors. J Clin Oncol. 25:3045–3054. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, et al: Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 28:2817–2823. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Goss GD, Arnold A, Shepherd FA, Dediu M, Ciuleanu TE, Fenton D, Zukin M, Walde D, Laberge F, Vincent MD, et al: Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study. J Clin Oncol. 28:49–55. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Dahut WL, Madan RA, Karakunnel JJ, Adelberg D, Gulley JL, Turkbey IB, Chau CH, Spencer SD, Mulquin M, Wright J, et al: Phase II clinical trial of cediranib in patients with metastatic castration-resistant prostate cancer. BJU Int. 111:1269–1280. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Martinho O, Silva-Oliveira R, Miranda-Gonçalves V, Clara C, Almeida JR, Carvalho AL, Barata JT and Reis RM: In vitro and in vivo analysis of RTK inhibitor efficacy and identification of its novel targets in glioblastomas. Transl Oncol. 6:187–196. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Miller KD, Miller M, Mehrotra S, Agarwal B, Mock BH, Zheng QH, Badve S, Hutchins GD and Sledge GW Jr: A physiologic imaging pilot study of breast cancer treated with AZD2171. Clin Cancer Res. 12:281–288. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Denduluri N, Tan AR, Walshe J, Berman A, Yang SX, Chow CK and Swain SM: A pilot study to evaluate the vascular endothelial growth factor receptor tyrosine kinase inhibitor AZD2171 and chemotherapy in locally advanced and inflammatory breast cancer. Clin Breast Cancer. 6:460–463. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Hyams DM, Chan A, de Oliveira C, Snyder R, Vinholes J, Audeh MW, Alencar VM, Lombard J, Mookerjee B, Xu J, et al: Cediranib in combination with fulvestrant in hormone-sensitive metastatic breast cancer: A randomized Phase II study. Invest New Drugs. 31:1345–1354. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Liu JF, Tolaney SM, Birrer M, Fleming GF, Buss MK, Dahlberg SE, Lee H, Whalen C, Tyburski K, Winer E, et al: A Phase 1 trial of the poly(ADP-ribose) polymerase inhibitor olaparib (AZD2281) in combination with the anti-angiogenic cediranib (AZD2171) in recurrent epithelial ovarian or triple-negative breast cancer. Eur J Cancer. 49:2972–2978. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Sahebjam S, Bedard PL, Castonguay V, Chen Z, Reedijk M, Liu G, Cohen B, Zhang WJ, Clarke B, Zhang T, et al: A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503). Br J Cancer. 109:943–949. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Almeida MI, Reis RM and Calin GA: MicroRNA history: Discovery, recent applications, and next frontiers. Mutat Res. 717:1–8. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M, et al: Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 101:2999–3004. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol. 302:1–12. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Garzon R, Marcucci G and Croce CM: Targeting microRNAs in cancer: Rationale, strategies and challenges. Nat Rev Drug Discov. 9:775–789. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Harquail J, Benzina S and Robichaud GA: MicroRNAs and breast cancer malignancy: An overview of miRNA-regulated cancer processes leading to metastasis. Cancer Biomark. 11:269–280. 2012.PubMed/NCBI

22 

Singh R and Mo YY: Role of microRNAs in breast cancer. Cancer Biol Ther. 14:201–212. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Valastyan S: Roles of microRNAs and other non-coding RNAs in breast cancer metastasis. J Mammary Gland Biol Neoplasia. 17:23–32. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Marino ALF, Evangelista AF, Vieira RAC, Macedo T, Kerr LM, Abrahão-Machado LF, Longatto-Filho A, Silveira HC and Marques MM: MicroRNA expression as risk biomarker of breast cancer metastasis: A pilot retrospective case-cohort study. BMC Cancer. 14:7392014. View Article : Google Scholar : PubMed/NCBI

25 

Wiemer EAC: Role of microRNAs in anti-cancer drug resistanceMicroRNAs in Cancer Translational Research. Cho WCS: Springer; Netherlands: pp. 449–483. 2011, http://link.springer.com/chapter/10.1007/978-94-007-0298-1_19Accessed November 20, 2013. View Article : Google Scholar

26 

Kastl L, Brown I and Schofield AC: miRNA-34a is associated with docetaxel resistance in human breast cancer cells. Breast Cancer Res Treat. 131:445–454. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Climent J, Dimitrow P, Fridlyand J, Palacios J, Siebert R, Albertson DG, Gray JW, Pinkel D, Lluch A and Martinez-Climent JA: Deletion of chromosome 11q predicts response to anthracycline-based chemotherapy in early breast cancer. Cancer Res. 67:818–826. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG and Yang JM: Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol. 76:582–588. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF and Pogribny IP: Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther. 7:2152–2159. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Liang Z, Wu H, Xia J, Li Y, Zhang Y, Huang K, Wagar N, Yoon Y, Cho HT, Scala S, et al: Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol. 79:817–824. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Andorfer CA, Necela BM, Thompson EA and Perez EA: MicroRNA signatures: Clinical biomarkers for the diagnosis and treatment of breast cancer. Trends Mol Med. 17:313–319. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Mahadevan D, Cooke L, Riley C, Swart R, Simons B, Della Croce K, Wisner L, Iorio M, Shakalya K, Garewal H, et al: A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors. Oncogene. 26:3909–3919. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Weiss GJ, Bemis LT, Nakajima E, Sugita M, Birks DK, Robinson WA, Varella-Garcia M, Bunn PA Jr, Haney J, Helfrich BA, et al: EGFR regulation by microRNA in lung cancer: Correlation with clinical response and survival to gefitinib and EGFR expression in cell lines. Ann Oncol. 19:1053–1059. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Dirks WG, Faehnrich S, Estella IAJ and Drexler HG: Short tandem repeat DNA typing provides an international reference standard for authentication of human cell lines. ALTEX. 22:103–109. 2005.PubMed/NCBI

35 

drc R Package. http://cran.r-project.org/web/packages/drc/

36 

The R project for statistical computing. http://www.r-project.org

37 

Pinto F, Pértega-Gomes N, Pereira MS, Vizcaíno JR, Monteiro P, Henrique RM, Baltazar F, Andrade RP and Reis RM: T-box transcription factor brachyury is associated with prostate cancer progression and aggressiveness. Clin Cancer Res. 20:4949–4961. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Martinho O, Zucca LE and Reis RM: AXL as a modulator of sunitinib response in glioblastoma cell lines. Exp Cell Res. 332:1–10. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Viana CR, Neto CS, Kerr LM, Palmero EI, Marques MMC, Colaiacovo T, de Queiroz Junior AF, Carvalho AL and Siqueira SA: The interference of cold ischemia time in the quality of total RNA from frozen tumor samples. Cell Tissue Bank. 14:167–173. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Macedo C, Evangelista AF, Marques MM, Octacílio-Silva S, Donadi EA, Sakamoto-Hojo ET and Passos GA: Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cells. Immunobiology. 218:554–560. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Aroma-light. http://www.bioconductor.org/packages/2.12/bioc/html/aroma.light.html

42 

Hong F, Breitling R, McEntee CW, Wittner BS, Nemhauser JL and Chory J: RankProd: A bioconductor package for detecting differentially expressed genes in meta-analysis. Bioinformatics. 22:2825–2827. 2006. View Article : Google Scholar : PubMed/NCBI

43 

gplots: Various R programming tools for plotting data. http://cran.r-project.org/web/packages/gplots/index.html

44 

mirDIP: microRNA data integration portal. http://ophid.utoronto.ca/mirDIP/

45 

Bioinformatics Resouces DAVID: 6.7. http://david.abcc.ncifcrf.gov

46 

Supek F, Bošnjak M, Škunca N and Šmuc T: REVIGO summarizes and visualizes long lists of gene ontology terms. PLoS One. 6:e218002011. View Article : Google Scholar : PubMed/NCBI

47 

Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e452001. View Article : Google Scholar : PubMed/NCBI

48 

Andersen CL, Jensen JL and Ørntoft TF: Normalization of real-time quantitative reverse transcription-PCR data: A model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res. 64:5245–5250. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Lindahl T, Satoh MS, Poirier GG and Klungland A: Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci. 20:405–411. 1995. View Article : Google Scholar : PubMed/NCBI

50 

Downward J: Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer. 3:11–22. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Tao LY, Liang YJ, Wang F, Chen LM, Yan YY, Dai CL and Fu LW: Cediranib (recentin, AZD2171) reverses ABCB1- and ABCC1-mediated multidrug resistance by inhibition of their transport function. Cancer Chemother Pharmacol. 64:961–969. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Tetsu O, Phuchareon J, Eisele DW, Hangauer MJ and McCormick F: AKT inactivation causes persistent drug tolerance to EGFR inhibitors. Pharmacol Res. 102:132–137. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Ford CE, Ma SS Qian, Quadir A and Ward RL: The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis. Int J Cancer. 133:779–787. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Henry C, Quadir A, Hawkins NJ, Jary E, Llamosas E, Kumar D, Daniels B, Ward RL and Ford CE: Expression of the novel Wnt receptor ROR2 is increased in breast cancer and may regulate both β-catenin dependent and independent Wnt signalling. J Cancer Res Clin Oncol. 141:243–254. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Malavaki CJ, Roussidis AE, Gialeli C, Kletsas D, Tsegenidis T, Theocharis AD, Tzanakakis GN and Karamanos NK: Imatinib as a key inhibitor of the platelet-derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells. FEBS J. 280:2477–2489. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Thanigaimani S, Kichenadasse G and Mangoni AA: The emerging role of vascular endothelial growth factor (VEGF) in vascular homeostasis: Lessons from recent trials with anti-VEGF drugs. Curr Vasc Pharmacol. 9:358–380. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Zhou M, Liu Z, Zhao Y, Ding Y, Liu H, Xi Y, Xiong W, Li G, Lu J, Fodstad O, et al: MicroRNA-125b confers the resistance of breast cancer cells to paclitaxel through suppression of pro-apoptotic Bcl-2 antagonist killer 1 (Bak1) expression. J Biol Chem. 285:21496–21507. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Nordentoft I, Birkenkamp-Demtroder K, Agerbæk M, Theodorescu D, Ostenfeld MS, Hartmann A, Borre M, Ørntoft TF and Dyrskjøt L: miRNAs associated with chemo-sensitivity in cell lines and in advanced bladder cancer. BMC Med Genomics. 5:402012. View Article : Google Scholar : PubMed/NCBI

59 

Yin W, Wang P, Wang X, Song W, Cui X, Yu H and Zhu W: Identification of microRNAs and mRNAs associated with multidrug resistance of human laryngeal cancer Hep-2 cells. Braz J Med Biol Res. 46:546–554. 2013. View Article : Google Scholar : PubMed/NCBI

60 

Lee K, Kunkeaw N, Jeon SH, Lee I, Johnson BH, Kang GY, Bang JY, Park HS, Leelayuwat C and Lee YS: Precursor miR-886, a novel noncoding RNA repressed in cancer, associates with PKR and modulates its activity. RNA. 17:1076–1089. 2011. View Article : Google Scholar : PubMed/NCBI

61 

Jeon SH, Lee K, Lee KS, Kunkeaw N, Johnson BH, Holthauzen LMF, Gong B, Leelayuwat C and Lee YS: Characterization of the direct physical interaction of nc886, a cellular non-coding RNA, and PKR. FEBS Lett. 586:3477–3484. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Jeon SH, Johnson BH and Lee YS: A tumor surveillance model: A non-coding RNA senses neoplastic cells and its protein partner signals cell death. Int J Mol Sci. 13:13134–13139. 2012. View Article : Google Scholar : PubMed/NCBI

63 

Cao J, Song Y, Bi N, Shen J, Liu W, Fan J, Sun G, Tong T, He J, Shi Y, et al: DNA methylation-mediated repression of miR-886-3p predicts poor outcome of human small cell lung cancer. Cancer Res. 73:3326–3335. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Xiong Y, Zhang L, Holloway AK, Wu X, Su L and Kebebew E: MiR-886-3p regulates cell proliferation and migration, and is dysregulated in familial non-medullary thyroid cancer. PLoS One. 6:e247172011. View Article : Google Scholar : PubMed/NCBI

65 

Noonan EJ, Place RF, Basak S, Pookot D and Li LC: miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells. Oncotarget. 1:349–358. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Miao LJ, Huang SF, Sun ZT, Gao ZY, Zhang RX, Liu Y and Wang J: MiR-449c targets c-Myc and inhibits NSCLC cell progression. FEBS Lett. 587:1359–1365. 2013. View Article : Google Scholar : PubMed/NCBI

67 

Luo W, Huang B, Li Z, Li H, Sun L, Zhang Q, Qiu X and Wang E: MicroRNA-449a is downregulated in non-small cell lung cancer and inhibits migration and invasion by targeting c-Met. PLoS One. 8:e647592013. View Article : Google Scholar : PubMed/NCBI

68 

Fang Y, Gu X, Li Z, Xiang J and Chen Z: miR-449b inhibits the proliferation of SW1116 colon cancer stem cells through downregulation of CCND1 and E2F3 expression. Oncol Rep. 30:399–406. 2013.PubMed/NCBI

69 

Bou Kheir T, Futoma-Kazmierczak E, Jacobsen A, Krogh A, Bardram L, Hother C, Grønbæk K, Federspiel B, Lund AH and Friis-Hansen L: miR-449 inhibits cell proliferation and is down-regulated in gastric cancer. Mol Cancer. 10:292011. View Article : Google Scholar : PubMed/NCBI

70 

Feng M and Yu Q: miR-449 regulates CDK-Rb-E2F1 through an auto-regulatory feedback circuit. Cell Cycle. 9:213–214. 2010. View Article : Google Scholar : PubMed/NCBI

71 

Yan F, Liu H, Hao J and Liu Z: Dynamical behaviors of Rb-E2F pathway including negative feedback loops involving miR449. PLoS One. 7:e439082012. View Article : Google Scholar : PubMed/NCBI

72 

Yang X, Feng M, Jiang X, Wu Z, Li Z, Aau M and Yu Q: miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A. Genes Dev. 23:2388–2393. 2009. View Article : Google Scholar : PubMed/NCBI

73 

Zhou X, Ren Y, Moore L, Mei M, You Y, Xu P, Wang B, Wang G, Jia Z, Pu P, et al: Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest. 90:144–155. 2010. View Article : Google Scholar : PubMed/NCBI

74 

Cho WCS, Chow ASC and Au JSK: MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1. RNA Biol. 8:125–131. 2011. View Article : Google Scholar : PubMed/NCBI

75 

Zhu H, Dougherty U, Robinson V, Mustafi R, Pekow J, Kupfer S, Li YC, Hart J, Goss K, Fichera A, et al: EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: Role of G1 regulators. Mol Cancer Res. 9:960–975. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bordinhão A, Evangelista A, Oliveira R, Macedo T, Silveira H, Reis R and Marques M: MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. Oncol Rep 36: 3197-3206, 2016.
APA
Bordinhão, A., Evangelista, A., Oliveira, R., Macedo, T., Silveira, H., Reis, R., & Marques, M. (2016). MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. Oncology Reports, 36, 3197-3206. https://doi.org/10.3892/or.2016.5153
MLA
Bordinhão, A., Evangelista, A., Oliveira, R., Macedo, T., Silveira, H., Reis, R., Marques, M."MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib". Oncology Reports 36.6 (2016): 3197-3206.
Chicago
Bordinhão, A., Evangelista, A., Oliveira, R., Macedo, T., Silveira, H., Reis, R., Marques, M."MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib". Oncology Reports 36, no. 6 (2016): 3197-3206. https://doi.org/10.3892/or.2016.5153
Copy and paste a formatted citation
x
Spandidos Publications style
Bordinhão A, Evangelista A, Oliveira R, Macedo T, Silveira H, Reis R and Marques M: MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. Oncol Rep 36: 3197-3206, 2016.
APA
Bordinhão, A., Evangelista, A., Oliveira, R., Macedo, T., Silveira, H., Reis, R., & Marques, M. (2016). MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib. Oncology Reports, 36, 3197-3206. https://doi.org/10.3892/or.2016.5153
MLA
Bordinhão, A., Evangelista, A., Oliveira, R., Macedo, T., Silveira, H., Reis, R., Marques, M."MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib". Oncology Reports 36.6 (2016): 3197-3206.
Chicago
Bordinhão, A., Evangelista, A., Oliveira, R., Macedo, T., Silveira, H., Reis, R., Marques, M."MicroRNA profiling in human breast cancer cell lines exposed to the anti-neoplastic drug cediranib". Oncology Reports 36, no. 6 (2016): 3197-3206. https://doi.org/10.3892/or.2016.5153
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