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Article

miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer

  • Authors:
    • Dong Wang
    • Junjie Ma
    • Xiangyu Ji
    • Feng Xu
    • Yucheng Wei
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Department of Thoracic Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China, Department of Anesthesia, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China
  • Pages: 608-616
    |
    Published online on: November 2, 2016
       https://doi.org/10.3892/or.2016.5214
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Abstract

The present study investigated the role of miR-141 regulation of eukaryotic initiation factor-4E (EIF4E) expression in docetaxel chemoresistance of human non-small cell lung cancer (NSCLC). The expression of miR-141 in docetaxel chemoresistant patients with NSCLCs was markedly higher than those of non-docetaxel chemoresistant patients with NSCLCs. The expression of EIF4E in docetaxel chemoresistant patients with NSCLCs was markedly lower than those of non-docetaxel chemoresistant patients with NSCLCs. Downregulation of miR-141 suppressed cell proliferation, induced cell death and increased caspase-3 activity in H1299 or H2009/docetaxel cells. Downregulation of miR-141 also increased the protein expression of EIF4E, VEGF, c-Myc and Bax in H1299 or H2009/docetaxel cells. Conversely, up­regulation of miR-141 promoted cell proliferation, inhibited cell death and caspase-3 activity in H1299 or H2009/docetaxel cell. Upregulation of miR-141 suppressed EIF4E, VEGF, c-Myc protein expression and inhibited Bax in H1299 or H2009/docetaxel cells. Thus, the present study is the first to show the induction of miR-141/EIF4E expression in an acquired model of docetaxel chemoresistant patients with NSCLCs. This serves as a mechanism of acquired docetaxel chemoresistant patients with NSCLCs, possibly through direct interactions with VEGF, c-Myc, and Bax, therefore presenting a potential therapeutic target for the treatment of docetaxel chemoresistant patients with NSCLCs.
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Copy and paste a formatted citation
Spandidos Publications style
Wang D, Ma J, Ji X, Xu F and Wei Y: miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. Oncol Rep 37: 608-616, 2017.
APA
Wang, D., Ma, J., Ji, X., Xu, F., & Wei, Y. (2017). miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. Oncology Reports, 37, 608-616. https://doi.org/10.3892/or.2016.5214
MLA
Wang, D., Ma, J., Ji, X., Xu, F., Wei, Y."miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer". Oncology Reports 37.1 (2017): 608-616.
Chicago
Wang, D., Ma, J., Ji, X., Xu, F., Wei, Y."miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer". Oncology Reports 37, no. 1 (2017): 608-616. https://doi.org/10.3892/or.2016.5214
Copy and paste a formatted citation
x
Spandidos Publications style
Wang D, Ma J, Ji X, Xu F and Wei Y: miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. Oncol Rep 37: 608-616, 2017.
APA
Wang, D., Ma, J., Ji, X., Xu, F., & Wei, Y. (2017). miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer. Oncology Reports, 37, 608-616. https://doi.org/10.3892/or.2016.5214
MLA
Wang, D., Ma, J., Ji, X., Xu, F., Wei, Y."miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer". Oncology Reports 37.1 (2017): 608-616.
Chicago
Wang, D., Ma, J., Ji, X., Xu, F., Wei, Y."miR-141 regulation of EIF4E expression affects docetaxel chemoresistance of non-small cell lung cancer". Oncology Reports 37, no. 1 (2017): 608-616. https://doi.org/10.3892/or.2016.5214
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