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Article

Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells

  • Authors:
    • Dong Hwan Kim
    • Min Jeong Kim
    • Bokyung Sung
    • Hongsuk Suh
    • Jee H. Jung
    • Hae Young Chung
    • Nam Deuk Kim
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Molecular Inflammation Research Center for Aging Intervention, Pusan National University, Busan 46241, Republic of Korea, Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Republic of Korea
  • Pages: 281-288
    |
    Published online on: November 7, 2016
       https://doi.org/10.3892/or.2016.5219
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Abstract

Resveratrol, a polyphenolic compound, is a naturally occurring phytochemical and is found in a variety of plants, including grapes, berries and peanuts. It has gained much attention for its potential anticancer activity against various types of human cancer. However, the usefulness of resveratrol as a chemotherapeutic agent is limited by its photosensitivity and metabolic instability. In this study the effects of a synthetic analogue of resveratrol, HS-1793, on the proliferation and apoptotic cell death were investigated using HCT116 human colon cancer cells. Although this compound has been reported to have anticancer activities in several human cancer cell lines, the therapeutic effects of HS-1793 on human colon cancer and its mechanisms of action have not been extensively studied. HS-1793 inhibited cell growth and induced apoptotic cell death in a concentration-dependent fashion. Induction of apoptosis was determined by morphological changes, cleavage of poly(ADP-ribose) polymerase, alteration of Bax/Bcl-2 expression ratio, and caspase activations. Flow cytometric analysis revealed that HS-1793 induced G2/M arrest in the cell cycle progression in HCT116 cells. Furthermore, HS-1793 showed more potent anticancer effects in several aspects than resveratrol in HCT116 cells. In addition, HS-1793 suppressed Akt and the phosphatidylinositol-3 kinase/Akt inhibitor LY294002 was found to enhance its induction of apoptosis. Thus, these findings suggest that HS-1793 have potential as a candidate chemotherapeutic agent against human colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Kim DH, Kim MJ, Sung B, Suh H, Jung JH, Chung HY and Kim ND: Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep 37: 281-288, 2017.
APA
Kim, D.H., Kim, M.J., Sung, B., Suh, H., Jung, J.H., Chung, H.Y., & Kim, N.D. (2017). Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncology Reports, 37, 281-288. https://doi.org/10.3892/or.2016.5219
MLA
Kim, D. H., Kim, M. J., Sung, B., Suh, H., Jung, J. H., Chung, H. Y., Kim, N. D."Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells". Oncology Reports 37.1 (2017): 281-288.
Chicago
Kim, D. H., Kim, M. J., Sung, B., Suh, H., Jung, J. H., Chung, H. Y., Kim, N. D."Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells". Oncology Reports 37, no. 1 (2017): 281-288. https://doi.org/10.3892/or.2016.5219
Copy and paste a formatted citation
x
Spandidos Publications style
Kim DH, Kim MJ, Sung B, Suh H, Jung JH, Chung HY and Kim ND: Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep 37: 281-288, 2017.
APA
Kim, D.H., Kim, M.J., Sung, B., Suh, H., Jung, J.H., Chung, H.Y., & Kim, N.D. (2017). Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncology Reports, 37, 281-288. https://doi.org/10.3892/or.2016.5219
MLA
Kim, D. H., Kim, M. J., Sung, B., Suh, H., Jung, J. H., Chung, H. Y., Kim, N. D."Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells". Oncology Reports 37.1 (2017): 281-288.
Chicago
Kim, D. H., Kim, M. J., Sung, B., Suh, H., Jung, J. H., Chung, H. Y., Kim, N. D."Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells". Oncology Reports 37, no. 1 (2017): 281-288. https://doi.org/10.3892/or.2016.5219
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