Open Access

Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses

  • Authors:
    • Hisanori Shoji
    • Masahiko Motegi
    • Yosuke Takakusagi
    • Takayuki Asao
    • Hiroyuki Kuwano
    • Takeo Takahashi
    • Kyoji Ogoshi
  • View Affiliations

  • Published online on: December 7, 2016     https://doi.org/10.3892/or.2016.5300
  • Pages: 695-704
  • Copyright: © Shoji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to evaluate a previously reported predictive formula of output-limiting symptoms induced by radiofrequency (RF) to determine the efficacy of this neoadjuvant chemoradiation (NACR) and concurrent RF thermal therapy. The present study included 81 consecutive patients with confirmed diagnoses of rectal adenocarcinoma that was localized in the mid-low rectum (up to 12 cm from the anal verge) who received NACR [intensity-modulated radiotherapy (IMRT), 50 Gy/25 fractions, capecitabine 1,700 mg/m2/day for 5 days/week)] with concurrent thermal therapy (Thermotron-RF8, once a week for 5 weeks with 50 min irradiation). Patients with progressive disease (PD) did not receive RF outputs higher than the predicted value. Some patients who were predicted to receive more output in fact received more than the predicted output. In patients who were predicted to receive moderately higher outputs, 37.5% of the patients experienced pathological complete responses, which was the highest rate, while in those who did not receive more than the predicted output, 66.7% of the patients experienced PD, which was the highest rate in the present study. We speculate that RF thermal therapy may offset the chemoradiation effects in some patients. Adding thermal therapy as a multimodality therapy to NACR potentially affects patients with lower predicted outputs and actual observed outputs slightly higher than the predictive value. Our predictive equation for initial energy output, in which output‑limiting symptoms can be used to predict treatment efficacy, consequently, can be used to decide whether to continue this treatment modality.
View Figures
View References

Related Articles

Journal Cover

February-2017
Volume 37 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shoji H, Motegi M, Takakusagi Y, Asao T, Kuwano H, Takahashi T and Ogoshi K: Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses. Oncol Rep 37: 695-704, 2017
APA
Shoji, H., Motegi, M., Takakusagi, Y., Asao, T., Kuwano, H., Takahashi, T., & Ogoshi, K. (2017). Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses. Oncology Reports, 37, 695-704. https://doi.org/10.3892/or.2016.5300
MLA
Shoji, H., Motegi, M., Takakusagi, Y., Asao, T., Kuwano, H., Takahashi, T., Ogoshi, K."Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses". Oncology Reports 37.2 (2017): 695-704.
Chicago
Shoji, H., Motegi, M., Takakusagi, Y., Asao, T., Kuwano, H., Takahashi, T., Ogoshi, K."Chemoradiotherapy and concurrent radiofrequency thermal therapy to treat primary rectal cancer and prediction of treatment responses". Oncology Reports 37, no. 2 (2017): 695-704. https://doi.org/10.3892/or.2016.5300