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Article

DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma

  • Authors:
    • Jie Sun
    • Fangfang Bi
    • Yang Yang
    • Yuan Zhang
    • Aihua Jin
    • Jinzi Li
    • Zhenhua Lin
  • View Affiliations / Copyright

    Affiliations: Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, Jilin 133002, P.R. China, Department of Internal Medicine, Yanbian University Hospital, Yanji, Jilin 133002, P.R. China, Department of Pediatrics, Yanbian University Hospital, Yanji, Jilin 133002, P.R. China
  • Pages: 857-864
    |
    Published online on: December 8, 2016
       https://doi.org/10.3892/or.2016.5302
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Abstract

DEK, a transcription factor, is involved in mRNA splicing, transcriptional control, cell division and differentiation. Recent studies suggest that DEK overexpression can promote tumorigenesis in a wide range of cancer cell types. However, little is known concerning the status of DEK in pancreatic ductal adenocarcinoma (PDAC). Based on the microarray data from Gene Expression Omnibus (GEO), the expression levels of DEK mRNA in PDAC tissues were significantly higher than levels in the adjacent non-tumor tissues. To explore the clinical features of DEK overexpression in PDAC, 87 PDAC and 52 normal pancreas tissues were selected for immunoenzyme staining of the DEK protein. Localization of the DEK protein was detected in PANC-1 pancreatic cancer cells using immunofluorescence (IF) staining. The correlations between DEK overexpression and the clinical features of PDAC were evaluated using the Chi-squared (χ2) and Fisher's exact tests. The survival rates were calculated by the Kaplan-Meier method, and the relationship between prognostic factors and patient survival was also analyzed by the Cox proportional hazard models. The expression levels of DEK mRNA in PDAC tissues were significantly higher than that in the adjacent non‑tumor tissues. The DEK protein showed a primarily nuclear staining pattern in PDAC. The positive rate of the DEK protein was 52.9% (46/87) in PDAC, which was significantly higher than that in the adjacent normal pancreatic tissues (7.7%, 4/52). DEK overexpression in PDAC was correlated with tumor size, histological grade, tumor‑node‑metastasis (TNM) stage and overall survival (OS) rates. In addition, multivariate analysis demonstrated that DEK overexpression was an independent prognostic factor along with histological grade and TNM stage in patients with PDAC. In conclusion, DEK overexpression is associated with PDAC progression and may be a potential biomarker for poor prognostic evaluation in PDAC.
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1 

Urayama S: Pancreatic cancer early detection: Expanding higher-risk group with clinical and metabolomics parameters. World J Gastroenterol. 21:1707–1717. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Vernejoul F, Faure P, Benali N, Calise D, Tiraby G, Pradayrol L, Susini C and Buscail L: Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models. Cancer Res. 62:6124–6131. 2002.PubMed/NCBI

3 

Recaldini C, Carrafiello G, Bertolotti E, Angeretti MG and Fugazzola C: Contrast-enhanced ultrasonograpic findings in pancreatic tumors. Int J Med Sci. 5:203–208. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Stathis A and Moore MJ: Advanced pancreatic carcinoma: Current treatment and future challenges. Nat Rev Clin Oncol. 7:163–172. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Lee SH, Kim H, Hwang JH, Lee HS, Cho JY, Yoon YS and Han HS: Breast cancer resistance protein expression is associated with early recurrence and decreased survival in resectable pancreatic cancer patients. Pathol Int. 62:167–175. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Liu K, Ji B, Zhang W, Liu S, Wang Y and Liu Y: Comparison of iodine-125 seed implantation and pancreaticoduodenectomy in the treatment of pancreatic cancer. Int J Med Sci. 11:893–896. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Yamashita K, Miyamoto A, Hama N, Asaoka T, Maeda S, Omiya H, Takami K, Doki Y, Mori M and Nakamori S: Survival impact of pulmonary metastasis as recurrence of pancreatic ductal adenocarcinoma. Dig Surg. 32:464–471. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Van den Broeck A, Vankelecom H, Van Eijsden R, Govaere O and Topal B: Molecular markers associated with outcome and metastasis in human pancreatic cancer. J Exp Clin Cancer Res. 31:682012. View Article : Google Scholar : PubMed/NCBI

9 

Niccolai E, Cappello P, Taddei A, Ricci F, D'Elios MM, Benagiano M, Bechi P, Bencini L, Ringressi MN, Coratti A, et al: Peripheral ENO1-specific T cells mirror the intratumoral immune response and their presence is a potential prognostic factor for pancreatic adenocarcinoma. Int J Oncol. 49:393–401. 2016.PubMed/NCBI

10 

Ma C, Nong K, Wu B, Dong B, Bai Y, Zhu H, Wang W, Huang X, Yuan Z and Ai K: miR-212 promotes pancreatic cancer cell growth and invasion by targeting the hedgehog signaling pathway receptor patched-1. J Exp Clin Cancer Res. 33:542014. View Article : Google Scholar : PubMed/NCBI

11 

von Lindern M, Fornerod M, van Baal S, Jaegle M, de Wit T, Buijs A and Grosveld G: The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol. 12:1687–1697. 1992. View Article : Google Scholar : PubMed/NCBI

12 

Khodadoust MS, Verhaegen M, Kappes F, Riveiro-Falkenbach E, Cigudosa JC, Kim DS, Chinnaiyan AM, Markovitz DM and Soengas MS: Melanoma proliferation and chemoresistance controlled by the DEK oncogene. Cancer Res. 69:6405–6413. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Shibata T, Kokubu A, Miyamoto M, Hosoda F, Gotoh M, Tsuta K, Asamura H, Matsuno Y, Kondo T, Imoto I, et al: DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung. Oncogene. 29:4671–4681. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Sammons M, Wan SS, Vogel NL, Mientjes EJ, Grosveld G and Ashburner BP: Negative regulation of the RelA/p65 transactivation function by the product of the DEK proto-oncogene. J Biol Chem. 281:26802–26812. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Gamble MJ and Fisher RP: SET and PARP1 remove DEK from chromatin to permit access by the transcription machinery. Nat Struct Mol Biol. 14:548–555. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Wise-Draper TM, Morreale RJ, Morris TA, Mintz-Cole RA, Hoskins EE, Balsitis SJ, Husseinzadeh N, Witte DP, Wikenheiser- Brokamp KA, Lambert PF, et al: DEK proto-oncogene expression interferes with the normal epithelial differentiation program. Am J Pathol. 174:71–81. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Kappes F, Fahrer J, Khodadoust MS, Tabbert A, Strasser C, Mor-Vaknin N, Moreno-Villanueva M, Bürkle A, Markovitz DM and Ferrando-May E: DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. Mol Cell Biol. 28:3245–3257. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Kroes RA, Jastrow A, McLone MG, Yamamoto H, Colley P, Kersey DS, Yong VW, Mkrdichian E, Cerullo L, Leestma J, et al: The identification of novel therapeutic targets for the treatment of malignant brain tumors. Cancer Lett. 156:191–198. 2000. View Article : Google Scholar : PubMed/NCBI

19 

von Lindern M, van Baal S, Wiegant J, Raap A, Hagemeijer A and Grosveld G: can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3 half to different genes: Characterization of the set gene. Mol Cell Biol. 12:3346–3355. 1992. View Article : Google Scholar : PubMed/NCBI

20 

Sanchez-Carbayo M, Socci ND, Lozano JJ, Li W, Charytonowicz E, Belbin TJ, Prystowsky MB, Ortiz AR, Childs G and Cordon-Cardo C: Gene discovery in bladder cancer progression using cDNA microarrays. Am J Pathol. 163:505–516. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Kondoh N, Wakatsuki T, Ryo A, Hada A, Aihara T, Horiuchi S, Goseki N, Matsubara O, Takenaka K, Shichita M, et al: Identification and characterization of genes associated with human hepatocellular carcinogenesis. Cancer Res. 59:4990–4996. 1999.PubMed/NCBI

22 

Lin L, Piao J, Gao W, Piao Y, Jin G, Ma Y, Li J and Lin Z: DEK over expression as an independent biomarker for poor prognosis in colorectal cancer. BMC Cancer. 13:3662013. View Article : Google Scholar : PubMed/NCBI

23 

Liu S, Wang X, Sun F, Kong J, Li Z and Lin Z: DEK overexpression is correlated with the clinical features of breast cancer. Pathol Int. 62:176–181. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Piao J, Shang Y, Liu S, Piao Y, Cui X, Li Y and Lin Z: High expression of DEK predicts poor prognosis of gastric adenocarcinoma. Diagn Pathol. 9:672014. View Article : Google Scholar : PubMed/NCBI

25 

Chatterjee D, Katz MH, Rashid A, Wang H, Iuga AC, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Crane CH, et al: Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma. Am J Surg Pathol. 36:409–417. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zhou HY, Wang Y, Zhang J, Ruan CP, Wang WJ, Sun YP and Hu ZQ: Retrograde vs conventional dissection technique in pancreaticoduodenectomy: A pilot study. JAMA Surg. 149:604–607. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Vinnedge LM Privette, Kappes F, Nassar N and Wells SI: Stacking the DEK: From chromatin topology to cancer stem cells. Cell Cycle. 12:51–66. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Pease NA, Wise-Draper T and Vinnedge L Privette: Dissecting the potential interplay of DEK functions in inflammation and cancer. J Oncol. 2015:1065172015. View Article : Google Scholar : PubMed/NCBI

29 

Kappes F, Damoc C, Knippers R, Przybylski M, Pinna LA and Gruss C: Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK. Mol Cell Biol. 24:6011–6020. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Sawatsubashi S, Murata T, Lim J, Fujiki R, Ito S, Suzuki E, Tanabe M, Zhao Y, Kimura S, Fujiyama S, et al: A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Genes Dev. 24:159–170. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Sandén C, Järvstråt L, Lennartsson A, Brattås PL, Nilsson B and Gullberg U: The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation. Mol Cancer. 13:2152014. View Article : Google Scholar : PubMed/NCBI

32 

Vinnedge LM Privette, McClaine R, Wagh PK, Wikenheiser-Brokamp KA, Waltz SE and Wells SI: The human DEK oncogene stimulates β-catenin signaling, invasion and mammosphere formation in breast cancer. Oncogene. 30:2741–2752. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Vinnedge LM Privette, Benight NM, Wagh PK, Pease NA, Nashu MA, Serrano-Lopez J, Adams AK, Cancelas JA, Waltz SE and Wells SI: The DEK oncogene promotes cellular proliferation through paracrine Wnt signaling in Ron receptor-positive breast cancers. Oncogene. 34:2325–2336. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Adams AK, Bolanos LC, Dexheimer PJ, Karns RA, Aronow BJ, Komurov K, Jegga AG, Casper KA, Patil YJ, Wilson KM, et al: IRAK1 is a novel DEK transcriptional target and is essential for head and neck cancer cell survival. Oncotarget. 6:43395–43407. 2015.PubMed/NCBI

35 

Datta A, Adelson ME, Mogilevkin Y, Mordechai E, Sidi AA and Trama JP: Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer. BMC Cancer. 11:2342011. View Article : Google Scholar : PubMed/NCBI

36 

Liu X, Qi D, Qi J, Mao Z, Li X, Zhang J, Li J and Gao W: Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma. Oncol Rep. 35:155–162. 2016.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun J, Bi F, Yang Y, Zhang Y, Jin A, Li J and Lin Z: DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma. Oncol Rep 37: 857-864, 2017.
APA
Sun, J., Bi, F., Yang, Y., Zhang, Y., Jin, A., Li, J., & Lin, Z. (2017). DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma. Oncology Reports, 37, 857-864. https://doi.org/10.3892/or.2016.5302
MLA
Sun, J., Bi, F., Yang, Y., Zhang, Y., Jin, A., Li, J., Lin, Z."DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma". Oncology Reports 37.2 (2017): 857-864.
Chicago
Sun, J., Bi, F., Yang, Y., Zhang, Y., Jin, A., Li, J., Lin, Z."DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma". Oncology Reports 37, no. 2 (2017): 857-864. https://doi.org/10.3892/or.2016.5302
Copy and paste a formatted citation
x
Spandidos Publications style
Sun J, Bi F, Yang Y, Zhang Y, Jin A, Li J and Lin Z: DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma. Oncol Rep 37: 857-864, 2017.
APA
Sun, J., Bi, F., Yang, Y., Zhang, Y., Jin, A., Li, J., & Lin, Z. (2017). DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma. Oncology Reports, 37, 857-864. https://doi.org/10.3892/or.2016.5302
MLA
Sun, J., Bi, F., Yang, Y., Zhang, Y., Jin, A., Li, J., Lin, Z."DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma". Oncology Reports 37.2 (2017): 857-864.
Chicago
Sun, J., Bi, F., Yang, Y., Zhang, Y., Jin, A., Li, J., Lin, Z."DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma". Oncology Reports 37, no. 2 (2017): 857-864. https://doi.org/10.3892/or.2016.5302
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