Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1021-335X Online ISSN: 1791-2431
Journal Cover
March-2017 Volume 37 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 37 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers

  • Authors:
    • Tiesong Zhang
    • Jing Ma
    • Chao Li
    • Ken Lin
    • Fan Lou
    • Hongchao Jiang
    • Yingqin Gao
    • Yanli Yang
    • Cheng Ming
    • Biao Ruan
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Head and Neck Surgery, Kunming Children's Hospital, Kunming, Yunnan 650032, P.R. China, Department of Anesthesiology, Kunming Children's Hospital, Kunming, Yunnan 650032, P.R. China, Department of Clinical Laboratory, Kunming Children's Hospital, Kunming, Yunnan 650032, P.R. China, Department of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China, Department of Otolaryngology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan 650032, P.R. China
  • Pages: 1653-1661
    |
    Published online on: January 13, 2017
       https://doi.org/10.3892/or.2017.5365
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Pediatric head and neck cancers account for overall 12% of all pediatric cancers. Despite recent advances in therapeutic modalities, children with tumor metastasis have poor prognosis. Therefore, there is an unmet need for new and effective treatment modalities for pediatric head and neck cancers. The present study describes a simple and efficient method for fabrication of cationic lipid‑polymer hybrid nanoparticles (CLPNs) for co‑delivery of cisplatin (CDDP) and DNA (CDDP/DNA CLPNs) for the therapy of childhood head and neck cancers. CDDP/DNA CLPNs were prepared by the modified double emulsion solvent evaporation method with self‑assembly. CDDP‑loaded CLPNs (CDDP CLPNs), CDDP-loaded polymeric nanoparticles (PNPs) (CDDP PNPs), and DNA‑loaded Lipofectamine® 2000 (DNA LIPO) were also prepared for comparison. The results illustrated that the concentration of the cationic lipid has influence on the characteristics of CLPNs. In vitro anticancer effect, in vitro transfection efficiency, in vivo antitumor and gene delivery efficacy of CDDP/DNA CLPNs have advantages over other formulations tested. In conclusion, outstanding delivery ability of CLPNs for both CDDP and DNA could combine the therapeutic efficiency of both drug and gene for the treatment of pediatric rhabdomyosarcoma (RMS).
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Ward E, DeSantis C, Robbins A, Kohler B and Jemal A: Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 64:83–103. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Choi DK and Schmidt ML: Chemotherapy in children with head and neck cancers: Perspectives and review of current therapies. Oral Maxillofacial Surg Clin N Am. 28:127–138. 2016. View Article : Google Scholar

3 

Marcus KJ and Tishler RB: Head and neck carcinomas across the age spectrum: Epidemiology, therapy, and late effects. Semin Radiat Oncol. 20:52–57. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Wang Y, Lipari P, Wang X, Hailey J, Liang L, Ramos R, Liu M, Pachter JA, Bishop WR and Wang Y: A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts. Mol Cancer Ther. 9:410–418. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Morrison R, Gardiner C, Evidente A, Kiss R and Townley H: Incorporation of ophiobolin a into novel chemoembolization particles for cancer cell treatment. Pharm Res. 31:2904–2917. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Xie M, Zhang H, Xu Y, Liu T, Chen S, Wang J and Zhang T: Expression of folate receptors in nasopharyngeal and laryngeal carcinoma and folate receptor-mediated endocytosis by molecular targeted nanomedicine. Int J Nanomed. 8:2443–2451. 2013. View Article : Google Scholar

7 

Chen Y, Xu G, Zheng Y, Yan M, Li Z, Zhou Y, Mei L and Li X: Nanoformulation of D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) diblock copolymer for siRNA targeting HIF-1α for nasopharyngeal carcinoma therapy. Int J Nanomed. 10:1375–1386. 2015.

8 

Koganti S, Jagani HV, Palanimuthu VR, Mathew JA, Rao MC and Rao JV: In vitro and in vivo evaluation of the efficacy of nanoformulation of siRNA as an adjuvant to improve the anticancer potential of cisplatin. Exp Mol Pathol. 94:137–147. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Oberoi HS, Nukolova NV, Kabanov AV and Bronich TK: Nanocarriers for delivery of platinum anticancer drugs. Adv Drug Deliv Rev. 65:1667–1685. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Kojima H, Iida M, Yaguchi Y, Suzuki R, Hayashi N, Moriyama H and Manome Y: Enhancement of cisplatin sensitivity in squamous cell carcinoma of the head and neck transfected with a survivin antisense gene. Arch Otolaryngol Head Neck Surg. 132:682–685. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Jiang M, Liu Z, Xiang Y, Ma H, Liu S, Liu Y and Zheng D: Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck squamous cell carcinoma. BMC Cancer. 11:542011. View Article : Google Scholar : PubMed/NCBI

12 

Shao Z, Shao J, Tan B, Guan S, Liu Z, Zhao Z, He F and Zhao J: Targeted lung cancer therapy: Preparation and optimization of transferrin-decorated nanostructured lipid carriers as novel nanomedicine for co-delivery of anticancer drugs and DNA. Int J Nanomed. 10:1223–1233. 2015. View Article : Google Scholar

13 

Teo PY, Cheng W, Hedrick JL and Yang YY: Co-delivery of drugs and plasmid DNA for cancer therapy. Adv Drug Deliv Rev. 98:41–63. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Yang T, Zhao P, Rong Z, Li B, Xue H, You J, He C, Li W, He X, Lee RJ, et al: Anti-tumor efficiency of lipid-coated cisplatin nanoparticles co-loaded with microRNA-375. Theranostics. 6:142–154. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Wasungu L and Hoekstra D: Cationic lipids, lipoplexes and intracellular delivery of genes. J Control Release. 116:255–264. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Zhang L, Chan JM, Gu FX, Rhee JW, Wang AZ, Radovic-Moreno AF, Alexis F, Langer R and Farokhzad OC: Self-assembled lipid - polymer hybrid nanoparticles: A robust drug delivery platform. ACS Nano. 2:1696–1702. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Yang XZ, Dou S, Wang YC, Long HY, Xiong MH, Mao CQ, Yao YD and Wang J: Single-step assembly of cationic lipid-polymer hybrid nanoparticles for systemic delivery of siRNA. ACS Nano. 6:4955–4965. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Bose RJ, Arai Y, Ahn JC, Park H and Lee SH: Influence of cationic lipid concentration on properties of lipid-polymer hybrid nanospheres for gene delivery. Int J Nanomed. 10:5367–5382. 2015.

19 

He C, Lu J and Lin W: Hybrid nanoparticles for combination therapy of cancer. J Control Release. 219:224–236. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Hadinoto K, Sundaresan A and Cheow WS: Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: A review. Eur J Pharm Biopharm. 85(3 Pt A): 427–443. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Guo S, Wang Y, Miao L, Xu Z, Lin CM, Zhang Y and Huang L: Lipid-coated Cisplatin nanoparticles induce neighboring effect and exhibit enhanced anticancer efficacy. ACS Nano. 7:9896–9904. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Han L, Ren Y, Long L, Zhong Y, Shen C, Pu P, Yuan X and Kang C: Inhibition of C6 glioma in vivo by combination chemotherapy of implantation of polymer wafer and intracarotid perfusion of transferrin-decorated nanoparticles. Oncol Rep. 27:121–128. 2012.PubMed/NCBI

23 

Nakata H, Miyazaki T, Iwasaki T, Nakamura A, Kidani T, Sakayama K, Masumoto J and Miura H: Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles. Oncol Rep. 33:1593–1598. 2015.PubMed/NCBI

24 

Yu W, Liu C, Ye J, Zou W, Zhang N and Xu W: Novel cationic SLN containing a synthesized single-tailed lipid as a modifier for gene delivery. Nanotechnology. 20:2151022009. View Article : Google Scholar : PubMed/NCBI

25 

Wang RH, Cao HM, Tian ZJ, Jin B, Wang Q, Ma H and Wu J: Efficacy of dual-functional liposomes containing paclitaxel for treatment of lung cancer. Oncol Rep. 33:783–791. 2015.PubMed/NCBI

26 

Yu W, Liu C, Liu Y, Zhang N and Xu W: Mannan-modified solid lipid nanoparticles for targeted gene delivery to alveolar macrophages. Pharm Res. 27:1584–1596. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Yang Q, Zhang S, Kang M, Dong R and Zhao J: Synergistic growth inhibition by sorafenib and cisplatin in human osteosarcoma cells. Oncol Rep. 33:2537–2544. 2015.PubMed/NCBI

28 

Almeida PV, Shahbazi MA, Mäkilä E, Kaasalainen M, Salonen J, Hirvonen J and Santos HA: Amine-modified hyaluronic acid-functionalized porous silicon nanoparticles for targeting breast cancer tumors. Nanoscale. 6:10377–10387. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Ye Y, Zhang X, Zhang T, Wang H and Wu B: Design and evaluation of injectable niclosamide nanocrystals prepared by wet media milling technique. Drug Dev Ind Pharm. 41:1416–1424. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, et al: Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells. Oncol Rep. 35:1101–1108. 2016.PubMed/NCBI

31 

Lv X, Liu F, Shang Y and Chen SZ: Honokiol exhibits enhanced antitumor effects with chloroquine by inducing cell death and inhibiting autophagy in human non-small cell lung cancer cells. Oncol Rep. 34:1289–1300. 2015.PubMed/NCBI

32 

Mainardes RM and Evangelista RC: PLGA nanoparticles containing praziquantel: Effect of formulation variables on size distribution. Int J Pharm. 290:137–144. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Liu P, Sun L, Zhou DS, Zhang P, Wang YH, Li D, Li QH and Feng RJ: Development of alendronate-conjugated poly (lactic-co-glycolic acid)-dextran nanoparticles for active targeting of cisplatin in osteosarcoma. Sci Rep. 5:173872015. View Article : Google Scholar : PubMed/NCBI

34 

Asthana S, Jaiswal AK, Gupta PK, Dube A and Chourasia MK: Th-1 biased immunomodulation and synergistic antileishmanial activity of stable cationic lipid-polymer hybrid nanoparticle: Biodistribution and toxicity assessment of encapsulated amphotericin B. Eur J Pharm Biopharm. 89:62–73. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Valencia PM, Basto PA, Zhang L, Rhee M, Langer R, Farokhzad OC and Karnik R: Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano. 4:1671–1679. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Seedat N, Kalhapure RS, Mocktar C, Vepuri S, Jadhav M, Soliman M and Govender T: Co-encapsulation of multi-lipids and polymers enhances the performance of vancomycin in lipid-polymer hybrid nanoparticles: In vitro and in silico studies. Mater Sci Eng C. 61:616–630. 2016. View Article : Google Scholar

37 

D'Mello S, Salem AK, Hong L and Elangovan S: Characterization and evaluation of the efficacy of cationic complex mediated plasmid DNA delivery in human embryonic palatal mesenchyme cells. J Tissue Eng Regen Med. 10:927–937. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Dong W, Jin GH, Li SF, Sun QM, Ma DY and Hua ZC: Cross-linked polyethylenimine as potential DNA vector for gene delivery with high efficiency and low cytotoxicity. Acta Biochim Biophys Sin (Shanghai). 38:780–787. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Khurana B, Goyal AK, Budhiraja A, Aora D and Vyas SP: Lipoplexes versus nanoparticles: pDNA/siRNA delivery. Drug Deliv. 20:57–64. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Krishnamurthy S, Vaiyapuri R, Zhang L and Chan JM: Lipid-coated polymeric nanoparticles for cancer drug delivery. Biomater Sci. 3:923–936. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang T, Ma J, Li C, Lin K, Lou F, Jiang H, Gao Y, Yang Y, Ming C, Ruan B, Ruan B, et al: Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers. Oncol Rep 37: 1653-1661, 2017.
APA
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H. ... Ruan, B. (2017). Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers. Oncology Reports, 37, 1653-1661. https://doi.org/10.3892/or.2017.5365
MLA
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H., Gao, Y., Yang, Y., Ming, C., Ruan, B."Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers". Oncology Reports 37.3 (2017): 1653-1661.
Chicago
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H., Gao, Y., Yang, Y., Ming, C., Ruan, B."Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers". Oncology Reports 37, no. 3 (2017): 1653-1661. https://doi.org/10.3892/or.2017.5365
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang T, Ma J, Li C, Lin K, Lou F, Jiang H, Gao Y, Yang Y, Ming C, Ruan B, Ruan B, et al: Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers. Oncol Rep 37: 1653-1661, 2017.
APA
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H. ... Ruan, B. (2017). Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers. Oncology Reports, 37, 1653-1661. https://doi.org/10.3892/or.2017.5365
MLA
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H., Gao, Y., Yang, Y., Ming, C., Ruan, B."Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers". Oncology Reports 37.3 (2017): 1653-1661.
Chicago
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H., Gao, Y., Yang, Y., Ming, C., Ruan, B."Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers". Oncology Reports 37, no. 3 (2017): 1653-1661. https://doi.org/10.3892/or.2017.5365
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team