Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers

  • Authors:
    • Tiesong Zhang
    • Jing Ma
    • Chao Li
    • Ken Lin
    • Fan Lou
    • Hongchao Jiang
    • Yingqin Gao
    • Yanli Yang
    • Cheng Ming
    • Biao Ruan
  • View Affiliations

  • Published online on: January 13, 2017     https://doi.org/10.3892/or.2017.5365
  • Pages: 1653-1661
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Abstract

Pediatric head and neck cancers account for overall 12% of all pediatric cancers. Despite recent advances in therapeutic modalities, children with tumor metastasis have poor prognosis. Therefore, there is an unmet need for new and effective treatment modalities for pediatric head and neck cancers. The present study describes a simple and efficient method for fabrication of cationic lipid‑polymer hybrid nanoparticles (CLPNs) for co‑delivery of cisplatin (CDDP) and DNA (CDDP/DNA CLPNs) for the therapy of childhood head and neck cancers. CDDP/DNA CLPNs were prepared by the modified double emulsion solvent evaporation method with self‑assembly. CDDP‑loaded CLPNs (CDDP CLPNs), CDDP-loaded polymeric nanoparticles (PNPs) (CDDP PNPs), and DNA‑loaded Lipofectamine® 2000 (DNA LIPO) were also prepared for comparison. The results illustrated that the concentration of the cationic lipid has influence on the characteristics of CLPNs. In vitro anticancer effect, in vitro transfection efficiency, in vivo antitumor and gene delivery efficacy of CDDP/DNA CLPNs have advantages over other formulations tested. In conclusion, outstanding delivery ability of CLPNs for both CDDP and DNA could combine the therapeutic efficiency of both drug and gene for the treatment of pediatric rhabdomyosarcoma (RMS).
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March-2017
Volume 37 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang T, Ma J, Li C, Lin K, Lou F, Jiang H, Gao Y, Yang Y, Ming C, Ruan B, Ruan B, et al: Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers. Oncol Rep 37: 1653-1661, 2017
APA
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H. ... Ruan, B. (2017). Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers. Oncology Reports, 37, 1653-1661. https://doi.org/10.3892/or.2017.5365
MLA
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H., Gao, Y., Yang, Y., Ming, C., Ruan, B."Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers". Oncology Reports 37.3 (2017): 1653-1661.
Chicago
Zhang, T., Ma, J., Li, C., Lin, K., Lou, F., Jiang, H., Gao, Y., Yang, Y., Ming, C., Ruan, B."Core‑shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers". Oncology Reports 37, no. 3 (2017): 1653-1661. https://doi.org/10.3892/or.2017.5365