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Article

MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2

  • Authors:
    • Shengli Hu
    • Huibin Chen
    • Yuqiang Zhang
    • Chaojia Wang
    • Kaijun Liu
    • Hui Wang
    • Jie Luo
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, P.R. China, Department of Surgery, The First People's Hospital of Qujing City, Qujing, Yunnan 655000, P.R. China
  • Pages: 1691-1697
    |
    Published online on: February 3, 2017
       https://doi.org/10.3892/or.2017.5421
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Abstract

Dysregulation of microRNAs (miRNAs) is actively involved in the development and progression of glioma. miR-520c was previously found to inhibit glioblastoma cell migration. However, the clinical significance of miR-520c and its biological function in glioma remain largely unknown. In the present study, we found that miR-520c expression in glioma tissues was significantly decreased compared to adjacent non‑cancerous tissues. The low level of miR-520c was prominently correlated with advanced World Health Organization (WHO) grade and decreased overall survival of glioma patients. Overexpression of miR-520c in U251 cells significantly decreased the migration and invasion of the cancer cells, while miR-520c silencing promoted U87 cell migration and invasion in vitro. Mechanistically, miR-520c inversely regulated transforming growth factor-β receptor type 2 (TGFBRII) abundance in the glioma cells. Herein, TGFBRII was found to be a downstream target of miR-520c in glioma. Furthermore, an inverse correlation between TGFBRII and miR-520c expression was observed in the glioma cases. In constrast, restoration of TGFBRII expression abrogated the effects of miR-520c overexpression in U251 cells with increased cell migration and invasion. In addition, miR-520c overexpression blocked TGF-β1‑induced cell migration and invasion in U251 cells. Collectively, miR-520c may serve as a prognostic predictor and a therapeutic target for glioma patients.
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Copy and paste a formatted citation
Spandidos Publications style
Hu S, Chen H, Zhang Y, Wang C, Liu K, Wang H and Luo J: MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2. Oncol Rep 37: 1691-1697, 2017.
APA
Hu, S., Chen, H., Zhang, Y., Wang, C., Liu, K., Wang, H., & Luo, J. (2017). MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2. Oncology Reports, 37, 1691-1697. https://doi.org/10.3892/or.2017.5421
MLA
Hu, S., Chen, H., Zhang, Y., Wang, C., Liu, K., Wang, H., Luo, J."MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2". Oncology Reports 37.3 (2017): 1691-1697.
Chicago
Hu, S., Chen, H., Zhang, Y., Wang, C., Liu, K., Wang, H., Luo, J."MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2". Oncology Reports 37, no. 3 (2017): 1691-1697. https://doi.org/10.3892/or.2017.5421
Copy and paste a formatted citation
x
Spandidos Publications style
Hu S, Chen H, Zhang Y, Wang C, Liu K, Wang H and Luo J: MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2. Oncol Rep 37: 1691-1697, 2017.
APA
Hu, S., Chen, H., Zhang, Y., Wang, C., Liu, K., Wang, H., & Luo, J. (2017). MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2. Oncology Reports, 37, 1691-1697. https://doi.org/10.3892/or.2017.5421
MLA
Hu, S., Chen, H., Zhang, Y., Wang, C., Liu, K., Wang, H., Luo, J."MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2". Oncology Reports 37.3 (2017): 1691-1697.
Chicago
Hu, S., Chen, H., Zhang, Y., Wang, C., Liu, K., Wang, H., Luo, J."MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2". Oncology Reports 37, no. 3 (2017): 1691-1697. https://doi.org/10.3892/or.2017.5421
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