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April-2017 Volume 37 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib

  • Authors:
    • Naokazu Chiba
    • Yosuke Ozawa
    • Kosuke Hikita
    • Masaaki Okihara
    • Toru Sano
    • Koichi Tomita
    • Kiminori Takano
    • Shigeyuki Kawachi
  • View Affiliations / Copyright

    Affiliations: Department of Digestive and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo 193-0998, Japan
  • Pages: 2270-2276
    |
    Published online on: February 23, 2017
       https://doi.org/10.3892/or.2017.5474
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Abstract

At advanced stages of hepatocellular carcinoma (HCC), the multikinase inhibitor sorafenib is the only effective treatment. Surrogate markers that predict the biological and clinical efficacy of sorafenib may help tailor treatment on an individual patient basis. In the present study, the clinical significance of the expression of HOXB9, a transcriptional factor, in HCC was assessed. Increased HOXB9 expression in HCC was found to be positively correlated with the expression of angiogenic factors, increased vascular invasion and was found to be associated with poor overall patient survival. Sorafenib treatment effectively suppressed the expression of angiogenic factors and activation of the Raf/MEK/ERK pathway in HOXB9-expressing HCC cell lines. Consistent with these findings, HCC patients, whose cancer expressed high levels of HOXB9, exhibited increased overall survival upon sorafenib treatment. Collectively, these results suggest that HOXB9 expression in HCC could be a surrogate marker for a beneficial response to sorafenib treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Chiba N, Ozawa Y, Hikita K, Okihara M, Sano T, Tomita K, Takano K and Kawachi S: Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib. Oncol Rep 37: 2270-2276, 2017.
APA
Chiba, N., Ozawa, Y., Hikita, K., Okihara, M., Sano, T., Tomita, K. ... Kawachi, S. (2017). Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib. Oncology Reports, 37, 2270-2276. https://doi.org/10.3892/or.2017.5474
MLA
Chiba, N., Ozawa, Y., Hikita, K., Okihara, M., Sano, T., Tomita, K., Takano, K., Kawachi, S."Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib". Oncology Reports 37.4 (2017): 2270-2276.
Chicago
Chiba, N., Ozawa, Y., Hikita, K., Okihara, M., Sano, T., Tomita, K., Takano, K., Kawachi, S."Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib". Oncology Reports 37, no. 4 (2017): 2270-2276. https://doi.org/10.3892/or.2017.5474
Copy and paste a formatted citation
x
Spandidos Publications style
Chiba N, Ozawa Y, Hikita K, Okihara M, Sano T, Tomita K, Takano K and Kawachi S: Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib. Oncol Rep 37: 2270-2276, 2017.
APA
Chiba, N., Ozawa, Y., Hikita, K., Okihara, M., Sano, T., Tomita, K. ... Kawachi, S. (2017). Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib. Oncology Reports, 37, 2270-2276. https://doi.org/10.3892/or.2017.5474
MLA
Chiba, N., Ozawa, Y., Hikita, K., Okihara, M., Sano, T., Tomita, K., Takano, K., Kawachi, S."Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib". Oncology Reports 37.4 (2017): 2270-2276.
Chicago
Chiba, N., Ozawa, Y., Hikita, K., Okihara, M., Sano, T., Tomita, K., Takano, K., Kawachi, S."Increased expression of HOXB9 in hepatocellular carcinoma predicts poor overall survival but a beneficial response to sorafenib". Oncology Reports 37, no. 4 (2017): 2270-2276. https://doi.org/10.3892/or.2017.5474
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