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Article

Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism

  • Authors:
    • Chao Wang
    • Huan Wang
    • Yaqian Zhang
    • Wei Guo
    • Cong Long
    • Jingchao Wang
    • Limei Liu
    • Xiaoping Sun
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Virology, Department of Pathogen Biology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China, Department of Pathology and Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, P.R. China, Corneal Disease Department of Weifang Eye Hospital, Weifang, Shandong 261041, P.R. China
  • Pages: 2109-2120
    |
    Published online on: March 2, 2017
       https://doi.org/10.3892/or.2017.5489
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Abstract

Nasopharyngeal carcinoma (NPC) is a malignancy derived from the epithelial cells of the nasopharynx cavity, and is closely associated with Epstein-Barr virus (EBV) infection. In addition to NPC, EBV causes various human malignancies, such as gastric cancer, hematological tumors and lymphoepithelioma-like carcinomas. Epstein-Barr nuclear antigen 1 (EBNA1) encoded by EBV is indispensable for replication, partition, transcription and maintenance of viral genomes. Berberine, a naturally occurring isoquinoline alkaloid, shows anti-inflammatory, anticholinergic, antioxidative, and anticancer activities. In the present study, the antitumor effect of berberine was studied. Cell Counting Kit-8 (CCK-8) assays were performed to demonstrate whether the proliferation of EBV-positive NPC cells was inhibited by berberine. Flow cytometric results revealed that berberine induced cell cycle arrest and apoptosis. Quantitative-PCR and western blotting results indicated that berberine decreased the expression of EBNA1 at both the mRNA and protein levels in the EBV-positive NPC cells. The function of EBNA1 promoter Qp which is to drive EBNA1 transcription in type Ⅱ latent infection was strongly suppressed by berberine. Overexpression of EBNA1 attenuated this inhibitory effect. Berberine also suppressed the activity of signal transducer and activator of transcription 3 which is a new therapeutic target in a series of malignancies, including NPC. Viral titer experiments demonstrated that berberine decreased the production of virions in HONE1 and HK1-EBV cells. In a mouse xenograft model of NPC induced by HONE1 cells, berberine significantly inhibited tumor formation. Altogether, these results indicate that berberine decreases the expression of EBNA1 and exhibits an antitumor effect against NPC both in vitro and in vivo.
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View References

1 

Martin KA, Lupey LN and Tempera I: Epstein-Barr virus oncoprotein LMP1 mediates epigenetic changes in host gene expression through PARP1. J Virol. 90:8520–8530. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Cui Q, Feng FT, Xu M, Liu WS, Yao YY, Xie SH, Li XZ, Ye ZL, Feng QS, Chen LZ, et al: Nasopharyngeal carcinoma risk prediction via salivary detection of host and Epstein-Barr virus genetic variants. Oncotarget. 2016.

3 

Xu M, Cheung CC, Chow C, Lun SW, Cheung ST and Lo KW: Overexpression of PIN1 enhances cancer growth and aggressiveness with cyclin D1 induction in EBV-associated nasopharyngeal carcinoma. PLoS One. 11:e01568332016. View Article : Google Scholar : PubMed/NCBI

4 

Sivachandran N, Thawe NN and Frappier L: Epstein-Barr virus nuclear antigen 1 replication and segregation functions in nasopharyngeal carcinoma cell lines. J Virol. 85:10425–10430. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Mansouri S, Pan Q, Blencowe BJ, Claycomb JM and Frappier L: Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer. J Virol. 88:11166–11177. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Houldcroft CJ and Kellam P: Host genetics of Epstein-Barr virus infection, latency and disease. Rev Med Virol. 25:71–84. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Zhu DD, Zhang J, Deng W, Yip YL, Lung HL, Tsang CM, Law WT, Yang J, Lau VM, Shuen WH, et al: Significance of NF-κB activation in immortalization of nasopharyngeal epithelial cells. Int J Cancer. 138:1175–1185. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Wang FW, Wu XR, Liu WJ, Liang YJ, Huang YF, Liao YJ, Shao CK, Zong YS, Mai SJ and Xie D: The nucleotide polymorphisms within the Epstein-Barr virus C and Q promoters from nasopharyngeal carcinoma affect transcriptional activity in vitro. Eur Arch Otorhinolaryngol. 269:931–938. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Shen Y, Zhang S, Sun R, Wu T and Qian J: Understanding the interplay between host immunity and Epstein-Barr virus in NPC patients. Emerg Microbes Infect. 4:e202015. View Article : Google Scholar : PubMed/NCBI

10 

Sam CK, Brooks LA, Niedobitek G, Young LS, Prasad U and Rickinson AB: Analysis of Epstein-Barr virus infection in nasopharyngeal biopsies from a group at high risk of nasopharyngeal carcinoma. Int J Cancer. 53:957–962. 1993. View Article : Google Scholar : PubMed/NCBI

11 

Kelly GL, Stylianou J, Rasaiyaah J, Wei W, Thomas W, Croom-Carter D, Kohler C, Spang R, Woodman C, Kellam P, et al: Different patterns of Epstein-Barr virus latency in endemic Burkitt lymphoma (BL) lead to distinct variants within the BL-associated gene expression signature. J Virol. 87:2882–2894. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Kempkes B and Ling PD: EBNA2 and its coactivator EBNA-LP. Curr Top Microbiol Immunol. 391:35–59. 2015.PubMed/NCBI

13 

Frappier L: Contributions of Epstein-Barr nuclear antigen 1 (EBNA1) to cell immortalization and survival. Viruses. 4:1537–1547. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Dheekollu J, Wiedmer A, Sentana-Lledo D, Cassel J, Messick T and Lieberman PM: HCF1 and OCT2 cooperate with EBNA1 to enhance OriP-dependent transcription and episome maintenance of latent Epstein-Barr virus. J Virol. 90:5353–5367. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Wood VH, O'Neil JD, Wei W, Stewart SE, Dawson CW and Young LS: Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways. Oncogene. 26:4135–4147. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Valentine R, Dawson CW, Hu C, Shah KM, Owen TJ, Date KL, Maia SP, Shao J, Arrand JR, Young LS, et al: Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation. Mol Cancer. 9:12010. View Article : Google Scholar : PubMed/NCBI

17 

Tempera I, De Leo A, Kossenkov AV, Cesaroni M, Song H, Dawany N, Showe L, Lu F, Wikramasinghe P and Lieberman PM: Identification of MEF2B, EBF1, and IL6R as direct gene targets of Epstein-Barr virus (EBV) nuclear antigen 1 critical for EBV-infected B-lymphocyte survival. J Virol. 90:345–355. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Holowaty MN, Sheng Y, Nguyen T, Arrowsmith C and Frappier L: Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP. J Biol Chem. 278:47753–47761. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Saridakis V, Sheng Y, Sarkari F, Holowaty MN, Shire K, Nguyen T, Zhang RG, Liao J, Lee W, Edwards AM, et al: Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization. Mol Cell. 18:25–36. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Wang FW, Wu XR, Liu WJ, Liao YJ, Lin S, Zong YS, Zeng MS, Zeng YX, Mai SJ and Xie D: Heat shock factor 1 upregulates transcription of Epstein-Barr Virus nuclear antigen 1 by binding to a heat shock element within the BamHI-Q promoter. Virology. 421:184–191. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Brooks L, Yao QY, Rickinson AB and Young LS: Epstein-Barr virus latent gene transcription in nasopharyngeal carcinoma cells: Coexpression of EBNA1, LMP1, and LMP2 transcripts. J Virol. 66:2689–2697. 1992.PubMed/NCBI

22 

Chen H, Lee JM, Zong Y, Borowitz M, Ng MH, Ambinder RF and Hayward SD: Linkage between STAT regulation and Epstein-Barr virus gene expression in tumors. J Virol. 75:2929–2937. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Chen H, Lee JM, Wang Y, Huang DP, Ambinder RF and Hayward SD: The Epstein-Barr virus latency BamHI-Q promoter is positively regulated by STATs and Zta interference with JAK/STAT activation leads to loss of BamHI-Q promoter activity. Proc Natl Acad Sci USA. 96:9339–9344. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Yu H and Jove R: The STATs of cancer - new molecular targets come of age. Nat Rev Cancer. 4:97–105. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Imai S, Kuroda M, Yamashita R and Ishiura Y: Therapeutic inhibition of Epstein-Barr virus-associated tumor cell growth by dominant-negative EBNA1. Uirusu. 55:239–249. 2005.(In Chinese). View Article : Google Scholar : PubMed/NCBI

26 

Coppotelli G, Mughal N, Callegari S, Sompallae R, Caja L, Luijsterburg MS, Dantuma NP, Moustakas A and Masucci MG: The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins. Nucleic Acids Res. 41:2950–2962. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Goto H, Kariya R, Shimamoto M, Kudo E, Taura M, Katano H and Okada S: Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway. Cancer Sci. 103:775–781. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Lin JP, Yang JS, Lee JH, Hsieh WT and Chung JG: Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line. World J Gastroenterol. 12:21–28. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Peng PL, Hsieh YS, Wang CJ, Hsu JL and Chou FP: Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Toxicol Appl Pharmacol. 214:8–15. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Kim JB, Yu JH, Ko E, Lee KW, Song AK, Park SY, Shin I, Han W and Noh DY: The alkaloid Berberine inhibits the growth of Anoikis-resistant MCF-7 and MDA-MB-231 breast cancer cell lines by inducing cell cycle arrest. Phytomedicine. 17:436–440. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Kishimoto A, Dong SF, Negishi H, Yasui N, Sun JN and Ikeda K: Effects of berberine on adipose tissues and kidney function in 3T3-L1 cells and spontaneously hypertensive rats. Nat Prod Commun. 10:1543–1546. 2015.PubMed/NCBI

32 

Bae YA and Cheon HG: Activating transcription factor-3 induction is involved in the anti-inflammatory action of berberine in RAW264.7 murine macrophages. Korean J Physiol Pharmacol. 20:415–424. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Wang J, Qi Q, Feng Z, Zhang X, Huang B, Chen A, Prestegarden L, Li X and Wang J: Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. Oncotarget. 7:66944–66958. 2016.PubMed/NCBI

34 

Barzegar E, Fouladdel S, Movahhed TK, Atashpour S, Ghahremani MH, Ostad SN and Azizi E: Effects of berberine on proliferation, cell cycle distribution and apoptosis of human breast cancer T47D and MCF7 cell lines. Iran J Basic Med Sci. 18:334–342. 2015.PubMed/NCBI

35 

Liu J, He C, Zhou K, Wang J and Kang JX: Coptis extracts enhance the anticancer effect of estrogen receptor antagonists on human breast cancer cells. Biochem Biophys Res Commun. 378:174–178. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Abukhdeir AM, Vitolo MI, Argani P, De Marzo AM, Karakas B, Konishi H, Gustin JP, Lauring J, Garay JP, Pendleton C, et al: Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci USA. 105:288–293. 2008. View Article : Google Scholar : PubMed/NCBI

37 

Kuo CL, Chi CW and Liu TY: Modulation of apoptosis by berberine through inhibition of cyclooxygenase-2 and Mcl-1 expression in oral cancer cells. In Vivo. 19:247–252. 2005.PubMed/NCBI

38 

Hwang JM, Kuo HC, Tseng TH, Liu JY and Chu CY: Berberine induces apoptosis through a mitochondria/caspases pathway in human hepatoma cells. Arch Toxicol. 80:62–73. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Park GB, Park SH, Kim D, Kim YS, Yoon SH and Hur DY: Berberine induces mitochondrial apoptosis of EBV-transformed B cells through p53-mediated regulation of XAF1 and GADD45α. Int J Oncol. 49:411–421. 2016.PubMed/NCBI

40 

Tsang CM, Cheung YC, Lui VW, Yip YL, Zhang G, Lin VW, Cheung KC, Feng Y and Tsao SW: Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts. BMC Cancer. 13:6192013. View Article : Google Scholar : PubMed/NCBI

41 

Sun X, Barlow EA, Ma S, Hagemeier SR, Duellman SJ, Burgess RR, Tellam J, Khanna R and Kenney SC: Hsp90 inhibitors block outgrowth of EBV-infected malignant cells in vitro and in vivo through an EBNA1-dependent mechanism. Proc Natl Acad Sci USA. 107:3146–3151. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Zhou H, Guo W, Long C, Wang H, Wang J and Sun X: Triptolide inhibits proliferation of Epstein-Barr virus-positive B lymphocytes by down-regulating expression of a viral protein LMP1. Biochem Biophys Res Commun. 456:815–820. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Long C, Guo W, Zhou H, Wang J, Wang H and Sun X: Triptolide decreases expression of latency-associated nuclear antigen 1 and reduces viral titers in Kaposi's sarcoma-associated and herpesvirus-related primary effusion lymphoma cells. Int J Oncol. 48:1519–1530. 2016.PubMed/NCBI

44 

Long C, Wang J, Guo W, Wang H, Wang C, Liu Y and Sun X: Triptolide inhibits transcription of hTERT through down-regulation of transcription factor specificity protein 1 in primary effusion lymphoma cells. Biochem Biophys Res Commun. 469:87–93. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Xu M, Xiao Y, Yin J, Hou W, Yu X, Shen L, Liu F, Wei L and Jia W: Berberine promotes glucose consumption independently of AMP-activated protein kinase activation. PLoS One. 9:e1037022014. View Article : Google Scholar : PubMed/NCBI

46 

Wu CC, Fang CY, Hsu HY, Chen YJ, Chou SP, Huang SY, Cheng YJ, Lin SF, Chang Y, Tsai CH, et al: Luteolin inhibits Epstein-Barr virus lytic reactivation by repressing the promoter activities of immediate-early genes. Antiviral Res. 132:99–110. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Choi ES, Nam JS, Jung JY, Cho NP and Cho SD: Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer. Sci Rep. 4:71622014. View Article : Google Scholar : PubMed/NCBI

48 

Saha SK and Khuda-Bukhsh AR: Berberine alters epigenetic modifications, disrupts microtubule network, and modulates HPV-18 E6-E7 oncoproteins by targeting p53 in cervical cancer cell HeLa: A mechanistic study including molecular docking. Eur J Pharmacol. 744:132–146. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Paiar F, Di Cataldo V, Zei G, Pasquetti EM, Cecchini S, Meattini I, Mangoni M, Agresti B, Iermano C, Bonomo P, et al: Role of chemotherapy in nasopharyngeal carcinoma. Oncol Rev. 6:e12012. View Article : Google Scholar : PubMed/NCBI

50 

Gu J, Yin L, Wu J, Zhang N, Huang T, Ding K, Cao H, Xu L and He X: Cetuximab and cisplatin show different combination effect in nasopharyngeal carcinoma cells lines via inactivation of EGFR/AKT signaling pathway. Biochem Res Int. 2016:70169072016. View Article : Google Scholar : PubMed/NCBI

51 

Frappier L: Role of EBNA1 in NPC tumourigenesis. Semin Cancer Biol. 22:154–161. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Li CH, Wu DF, Ding H, Zhao Y, Zhou KY and Xu DF: Berberine hydrochloride impact on physiological processes and modulation of twist levels in nasopharyngeal carcinoma CNE-1 cells. Asian Pac J Cancer Prev. 15:1851–1857. 2014. View Article : Google Scholar : PubMed/NCBI

53 

O'Neil JD, Owen TJ, Wood VH, Date KL, Valentine R, Chukwuma MB, Arrand JR, Dawson CW and Young LS: Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro. J Gen Virol. 89:2833–2842. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Aziz MH, Hafeez BB, Sand JM, Pierce DB, Aziz SW, Dreckschmidt NE and Verma AK: Protein kinase Cε mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2). Oncogene. 29:3100–3109. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Liu YP, Tan YN, Wang ZL, Zeng L, Lu ZX, Li LL, Luo W, Tang M and Cao Y: Phosphorylation and nuclear translocation of STAT3 regulated by the Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Int J Mol Med. 21:153–162. 2008.PubMed/NCBI

56 

Kennedy G, Komano J and Sugden B: Epstein-Barr virus provides a survival factor to Burkitt's lymphomas. Proc Natl Acad Sci USA. 100:14269–14274. 2003. View Article : Google Scholar : PubMed/NCBI

57 

Hong M, Murai Y, Kutsuna T, Takahashi H, Nomoto K, Cheng CM, Ishizawa S, Zhao QL, Ogawa R, Harmon BV, et al: Suppression of Epstein-Barr nuclear antigen 1 (EBNA1) by RNA interference inhibits proliferation of EBV-positive Burkitt's lymphoma cells. J Cancer Res Clin Oncol. 132:1–8. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Yin Q and Flemington EK: siRNAs against the Epstein Barr virus latency replication factor, EBNA1, inhibit its function and growth of EBV-dependent tumor cells. Virology. 346:385–393. 2006. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Wang C, Wang H, Zhang Y, Guo W, Long C, Wang J, Liu L and Sun X: Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncol Rep 37: 2109-2120, 2017.
APA
Wang, C., Wang, H., Zhang, Y., Guo, W., Long, C., Wang, J. ... Sun, X. (2017). Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncology Reports, 37, 2109-2120. https://doi.org/10.3892/or.2017.5489
MLA
Wang, C., Wang, H., Zhang, Y., Guo, W., Long, C., Wang, J., Liu, L., Sun, X."Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism". Oncology Reports 37.4 (2017): 2109-2120.
Chicago
Wang, C., Wang, H., Zhang, Y., Guo, W., Long, C., Wang, J., Liu, L., Sun, X."Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism". Oncology Reports 37, no. 4 (2017): 2109-2120. https://doi.org/10.3892/or.2017.5489
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Spandidos Publications style
Wang C, Wang H, Zhang Y, Guo W, Long C, Wang J, Liu L and Sun X: Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncol Rep 37: 2109-2120, 2017.
APA
Wang, C., Wang, H., Zhang, Y., Guo, W., Long, C., Wang, J. ... Sun, X. (2017). Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncology Reports, 37, 2109-2120. https://doi.org/10.3892/or.2017.5489
MLA
Wang, C., Wang, H., Zhang, Y., Guo, W., Long, C., Wang, J., Liu, L., Sun, X."Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism". Oncology Reports 37.4 (2017): 2109-2120.
Chicago
Wang, C., Wang, H., Zhang, Y., Guo, W., Long, C., Wang, J., Liu, L., Sun, X."Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism". Oncology Reports 37, no. 4 (2017): 2109-2120. https://doi.org/10.3892/or.2017.5489
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