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Article

Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727

  • Authors:
    • Xiaolong Zhang
    • Xiaoyi Wu
    • Fangling Zhang
    • Shouyong Mo
    • Yuanyuan Lu
    • Wei Wei
    • Xiaoling Chen
    • Linhua Lan
    • Bin Lu
    • Yongzhang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Protein Quality Control and Diseases Laboratory, Cancer Center, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China, The Second Clinical Medical School, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China
  • Pages: 2237-2244
    |
    Published online on: March 13, 2017
       https://doi.org/10.3892/or.2017.5503
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Abstract

Paclitaxel induces apoptosis in a variety of cancer cells. However, the mechanism of paclitaxel inducing apoptosis in human esophageal squamous cell carcinoma (ESCC) remains to be defined. In this study, we found that paclitaxel-induced apoptosis by increasing the relevant apoptosis protein expression and the release of cytochrome c via downregulation of signal transducer and activator of transcription 3 (STAT3) and phospho-STAT3 (Ser727). In addition, paclitaxel treatment of ESCC cells EC-1 and Eca-109 led to marked mitochondrial membrane potential depolarization and significantly increasing of reactive oxygen species. Moreover, paclitaxel treatment resulted in the inhibition of mitochondrial respiration. In conclusion, our findings reveal that paclitaxel induced apoptosis in both EC-1 and Eca-109 cells through the reduction of STAT3 and phospho‑STAT3 (Ser727) level, and suggest that paclitaxel may be of therapeutic potential in the treatment of ESCC through the induction of mitochondrial apoptosis in ESCC cells.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Wu X, Zhang F, Mo S, Lu Y, Wei W, Chen X, Lan L, Lu B, Liu Y, Liu Y, et al: Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncol Rep 37: 2237-2244, 2017.
APA
Zhang, X., Wu, X., Zhang, F., Mo, S., Lu, Y., Wei, W. ... Liu, Y. (2017). Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology Reports, 37, 2237-2244. https://doi.org/10.3892/or.2017.5503
MLA
Zhang, X., Wu, X., Zhang, F., Mo, S., Lu, Y., Wei, W., Chen, X., Lan, L., Lu, B., Liu, Y."Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727". Oncology Reports 37.4 (2017): 2237-2244.
Chicago
Zhang, X., Wu, X., Zhang, F., Mo, S., Lu, Y., Wei, W., Chen, X., Lan, L., Lu, B., Liu, Y."Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727". Oncology Reports 37, no. 4 (2017): 2237-2244. https://doi.org/10.3892/or.2017.5503
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Wu X, Zhang F, Mo S, Lu Y, Wei W, Chen X, Lan L, Lu B, Liu Y, Liu Y, et al: Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncol Rep 37: 2237-2244, 2017.
APA
Zhang, X., Wu, X., Zhang, F., Mo, S., Lu, Y., Wei, W. ... Liu, Y. (2017). Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727. Oncology Reports, 37, 2237-2244. https://doi.org/10.3892/or.2017.5503
MLA
Zhang, X., Wu, X., Zhang, F., Mo, S., Lu, Y., Wei, W., Chen, X., Lan, L., Lu, B., Liu, Y."Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727". Oncology Reports 37.4 (2017): 2237-2244.
Chicago
Zhang, X., Wu, X., Zhang, F., Mo, S., Lu, Y., Wei, W., Chen, X., Lan, L., Lu, B., Liu, Y."Paclitaxel induces apoptosis of esophageal squamous cell carcinoma cells by downregulating STAT3 phosphorylation at Ser727". Oncology Reports 37, no. 4 (2017): 2237-2244. https://doi.org/10.3892/or.2017.5503
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