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Article

MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer

  • Authors:
    • Yanjun Cai
    • Jian Ruan
    • Xueqing Yao
    • Liang Zhao
    • Baocheng Wang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Jinan Clinical College of the Second Military Medical University, Jinan, Shandong, P.R. China, Cancer Center, Traditional Chinese Medicine-Integrated Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China, Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, Guangdong, P.R. China, Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, P.R. China
  • Pages: 2787-2794
    |
    Published online on: April 3, 2017
       https://doi.org/10.3892/or.2017.5548
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Abstract

MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lung cancer (NSCLC) is poorly understood. In the present study, the role of miR-187 in the progression of NSCLC was investigated. Our results revealed that miR-187 was frequently upregulated in NSCLC tissues and cells. Furthermore, ectopic introduction of miR-187 promoted cell migration, whereas miR-187 inhibitor had the contrary effect in NSCLC cells. Of significance, miR-187 induced epithelial-mesenchymal transition (EMT), which plays a pivotal role in the initiation of metastasis and activated mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathways. Polymerase I and transcript release factor (PTRF) was identified as a direct target of miR-187 in the promotion of the migration of NSCLC cells. Restored expression of PTRF neutralized the promoting effect of miR-187 on cell migration and EMT of NSCLC cells. Collectively, our data highlight the pivotal role of miR-187 in the progression of NSCLC, indicating this factor as a potential candidate in molecular cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Cai Y, Ruan J, Yao X, Zhao L and Wang B: MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncol Rep 37: 2787-2794, 2017.
APA
Cai, Y., Ruan, J., Yao, X., Zhao, L., & Wang, B. (2017). MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncology Reports, 37, 2787-2794. https://doi.org/10.3892/or.2017.5548
MLA
Cai, Y., Ruan, J., Yao, X., Zhao, L., Wang, B."MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer". Oncology Reports 37.5 (2017): 2787-2794.
Chicago
Cai, Y., Ruan, J., Yao, X., Zhao, L., Wang, B."MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer". Oncology Reports 37, no. 5 (2017): 2787-2794. https://doi.org/10.3892/or.2017.5548
Copy and paste a formatted citation
x
Spandidos Publications style
Cai Y, Ruan J, Yao X, Zhao L and Wang B: MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncol Rep 37: 2787-2794, 2017.
APA
Cai, Y., Ruan, J., Yao, X., Zhao, L., & Wang, B. (2017). MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncology Reports, 37, 2787-2794. https://doi.org/10.3892/or.2017.5548
MLA
Cai, Y., Ruan, J., Yao, X., Zhao, L., Wang, B."MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer". Oncology Reports 37.5 (2017): 2787-2794.
Chicago
Cai, Y., Ruan, J., Yao, X., Zhao, L., Wang, B."MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer". Oncology Reports 37, no. 5 (2017): 2787-2794. https://doi.org/10.3892/or.2017.5548
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