MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer

  • Authors:
    • Yanjun Cai
    • Jian Ruan
    • Xueqing Yao
    • Liang Zhao
    • Baocheng Wang
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  • Published online on: April 3, 2017     https://doi.org/10.3892/or.2017.5548
  • Pages: 2787-2794
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Abstract

MicroRNAs (miRNAs) that negatively regulate gene expression play a key role in the development and progression of cancer. Aberrant expression of hsa-miR-187 (miR-187) has been reported in various malignancies. However, the function of miR-187 in tumor progression remains controversial and its role in non-small cell lung cancer (NSCLC) is poorly understood. In the present study, the role of miR-187 in the progression of NSCLC was investigated. Our results revealed that miR-187 was frequently upregulated in NSCLC tissues and cells. Furthermore, ectopic introduction of miR-187 promoted cell migration, whereas miR-187 inhibitor had the contrary effect in NSCLC cells. Of significance, miR-187 induced epithelial-mesenchymal transition (EMT), which plays a pivotal role in the initiation of metastasis and activated mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) pathways. Polymerase I and transcript release factor (PTRF) was identified as a direct target of miR-187 in the promotion of the migration of NSCLC cells. Restored expression of PTRF neutralized the promoting effect of miR-187 on cell migration and EMT of NSCLC cells. Collectively, our data highlight the pivotal role of miR-187 in the progression of NSCLC, indicating this factor as a potential candidate in molecular cancer therapy.
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May-2017
Volume 37 Issue 5

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Cai Y, Ruan J, Yao X, Zhao L and Wang B: MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncol Rep 37: 2787-2794, 2017
APA
Cai, Y., Ruan, J., Yao, X., Zhao, L., & Wang, B. (2017). MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer. Oncology Reports, 37, 2787-2794. https://doi.org/10.3892/or.2017.5548
MLA
Cai, Y., Ruan, J., Yao, X., Zhao, L., Wang, B."MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer". Oncology Reports 37.5 (2017): 2787-2794.
Chicago
Cai, Y., Ruan, J., Yao, X., Zhao, L., Wang, B."MicroRNA-187 modulates epithelial-mesenchymal transition by targeting PTRF in non-small cell lung cancer". Oncology Reports 37, no. 5 (2017): 2787-2794. https://doi.org/10.3892/or.2017.5548