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Article

MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2

Corrigendum in: /10.3892/or.2022.8413
  • Authors:
    • Deyao Wu
    • Xiaobing Niu
    • Jun Tao
    • Pengchao Li
    • Qiang Lu
    • Aiming Xu
    • Wei Chen
    • Zengjun Wang
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Reproductive Medicine and Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China
  • Pages: 3502-3508
    |
    Published online on: April 27, 2017
       https://doi.org/10.3892/or.2017.5607
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Abstract

Bladder cancer is the second most common urological malignancy in the US and is the most frequently diagnosed urological malignancy in China. An increasing amount of evidence indicates that microRNAs perform extremely important functions in many biological processes related to the formation and progression of cancers, including bladder cancer. Previous studies have reported that microRNA‑379-5p (miR-379-5p) is involved in tumour initiation and development in human cancers. However, the expression pattern, biological functions and the underlying mechanisms of miR-379-5p in bladder cancer remain unknown. The present study demonstrated that the expression levels of miR‑379-5p in bladder cancer tissues and cell lines were lower than the levels in adjacent normal tissues and the human bladder epithelial immortalized SV-HUC-1 cell line. Restoration of the expression of miR-379-5p inhibited bladder cancer cell proliferation, migration and invasion. Mouse double minute 2 (MDM2) was identified as a direct target gene of miR-379-5p. Furthermore, similar to miR-379-5p overexpression in bladder cancer cells, inhibition of MDM2 exerted tumor-suppressive effects. Rescue experiments showed that upregulation of MDM2 reversed the inhibitory effects of miR-379-5p on bladder cancer cell proliferation, migration and invasion. MDM2 was highly expressed and inversely correlated with miR-379-5p expression in bladder cancer tissues. These findings suggest that the miR-379-5p/MDM2 pathway plays an important role in bladder cancer and could serve as a potential candidate for bladder cancer therapeutics.
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Copy and paste a formatted citation
Spandidos Publications style
Wu D, Niu X, Tao J, Li P, Lu Q, Xu A, Chen W and Wang Z: MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413. Oncol Rep 37: 3502-3508, 2017.
APA
Wu, D., Niu, X., Tao, J., Li, P., Lu, Q., Xu, A. ... Wang, Z. (2017). MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413. Oncology Reports, 37, 3502-3508. https://doi.org/10.3892/or.2017.5607
MLA
Wu, D., Niu, X., Tao, J., Li, P., Lu, Q., Xu, A., Chen, W., Wang, Z."MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413". Oncology Reports 37.6 (2017): 3502-3508.
Chicago
Wu, D., Niu, X., Tao, J., Li, P., Lu, Q., Xu, A., Chen, W., Wang, Z."MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413". Oncology Reports 37, no. 6 (2017): 3502-3508. https://doi.org/10.3892/or.2017.5607
Copy and paste a formatted citation
x
Spandidos Publications style
Wu D, Niu X, Tao J, Li P, Lu Q, Xu A, Chen W and Wang Z: MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413. Oncol Rep 37: 3502-3508, 2017.
APA
Wu, D., Niu, X., Tao, J., Li, P., Lu, Q., Xu, A. ... Wang, Z. (2017). MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413. Oncology Reports, 37, 3502-3508. https://doi.org/10.3892/or.2017.5607
MLA
Wu, D., Niu, X., Tao, J., Li, P., Lu, Q., Xu, A., Chen, W., Wang, Z."MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413". Oncology Reports 37.6 (2017): 3502-3508.
Chicago
Wu, D., Niu, X., Tao, J., Li, P., Lu, Q., Xu, A., Chen, W., Wang, Z."MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2 Corrigendum in /10.3892/or.2022.8413". Oncology Reports 37, no. 6 (2017): 3502-3508. https://doi.org/10.3892/or.2017.5607
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