Open Access

MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4

  • Authors:
    • Chengyi Jiang
    • Hongtao Wang
    • Lei Zhou
    • Tao Jiang
    • Yajia Xu
    • Lin Xia
  • View Affiliations

  • Published online on: May 15, 2017     https://doi.org/10.3892/or.2017.5641
  • Pages: 82-88
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs are important factors in the pathogenic processes of human types of cancers including nasopharyngeal carcinoma (NPC). In the present study, we confirmed that the microRNA-212 expression level was significantly decreased both in NPC tissues and NPC cell lines. Decreased expression of miR-212 was associated with advanced tumor-node-metastasis (TNM) stage and metastasis of NPC. Patients with a lower level of miR-212 had significantly decreased rates of overall and disease-free survival. Functional experiments showed that forced expression of miR-212 inhibited the migration and invasion of NPC cells while inhibition of miR-212 increased the migration and invasion of NPC cells. Furthermore, the results of luciferase assay, qRT-PCR and western blotting showed that SOX4 was the direct downstream target of miR-212 in NPC cells. In addition, we further confirmed that miR-212 exerted its inhibitory influence on the migration and invasion of NPC cells by targeting SOX4.

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July 2017
Volume 38 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
APA
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., & Xia, L. (2017). MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4. Oncology Reports, 38, 82-88. https://doi.org/10.3892/or.2017.5641
MLA
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., Xia, L."MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4". Oncology Reports 38.1 (2017): 82-88.
Chicago
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., Xia, L."MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4". Oncology Reports 38, no. 1 (2017): 82-88. https://doi.org/10.3892/or.2017.5641