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Article Open Access

MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4

Retraction in: /10.3892/or.2023.8570
  • Authors:
    • Chengyi Jiang
    • Hongtao Wang
    • Lei Zhou
    • Tao Jiang
    • Yajia Xu
    • Lin Xia
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, P.R. China, Department of Immunology, Bengbu Medical College, Bengbu, Anhui, P.R. China, Department of Pathology, Bengbu Medical College, Bengbu, Anhui, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 82-88
    |
    Published online on: May 15, 2017
       https://doi.org/10.3892/or.2017.5641
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Abstract

MicroRNAs are important factors in the pathogenic processes of human types of cancers including nasopharyngeal carcinoma (NPC). In the present study, we confirmed that the microRNA-212 expression level was significantly decreased both in NPC tissues and NPC cell lines. Decreased expression of miR-212 was associated with advanced tumor-node-metastasis (TNM) stage and metastasis of NPC. Patients with a lower level of miR-212 had significantly decreased rates of overall and disease-free survival. Functional experiments showed that forced expression of miR-212 inhibited the migration and invasion of NPC cells while inhibition of miR-212 increased the migration and invasion of NPC cells. Furthermore, the results of luciferase assay, qRT-PCR and western blotting showed that SOX4 was the direct downstream target of miR-212 in NPC cells. In addition, we further confirmed that miR-212 exerted its inhibitory influence on the migration and invasion of NPC cells by targeting SOX4.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang C, Wang H, Zhou L, Jiang T, Xu Y and Xia L: MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570. Oncol Rep 38: 82-88, 2017.
APA
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., & Xia, L. (2017). MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570. Oncology Reports, 38, 82-88. https://doi.org/10.3892/or.2017.5641
MLA
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., Xia, L."MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570". Oncology Reports 38.1 (2017): 82-88.
Chicago
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., Xia, L."MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570". Oncology Reports 38, no. 1 (2017): 82-88. https://doi.org/10.3892/or.2017.5641
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang C, Wang H, Zhou L, Jiang T, Xu Y and Xia L: MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570. Oncol Rep 38: 82-88, 2017.
APA
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., & Xia, L. (2017). MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570. Oncology Reports, 38, 82-88. https://doi.org/10.3892/or.2017.5641
MLA
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., Xia, L."MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570". Oncology Reports 38.1 (2017): 82-88.
Chicago
Jiang, C., Wang, H., Zhou, L., Jiang, T., Xu, Y., Xia, L."MicroRNA-212 inhibits the metastasis of nasopharyngeal carcinoma by targeting SOX4 Retraction in /10.3892/or.2023.8570". Oncology Reports 38, no. 1 (2017): 82-88. https://doi.org/10.3892/or.2017.5641
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