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Article

Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome

  • Authors:
    • Agnieszka Rybarczyk
    • Jakub Klacz
    • Agata Wronska
    • Marcin Matuszewski
    • Zbigniew Kmiec
    • Piotr M. Wierzbicki
  • View Affiliations / Copyright

    Affiliations: Department of Histology, Faculty of Medicine, Medical University of Gdansk, 80211 Gdansk, Poland, Department of Urology, Faculty of Medicine, Medical University of Gdansk, 80402 Gdansk, Poland
  • Pages: 427-439
    |
    Published online on: May 15, 2017
       https://doi.org/10.3892/or.2017.5642
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Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of RCC (70-80%). Yes-associated protein 1 (YAP1) protein is a nuclear effector of the Hippo pathway and acts as a transcriptional co-activator of genes involved in the processes of growth and development of tissues. Hippo signaling, with its key kinases, MST2 and large tumor suppressor kinase 1 (LATS1), plays a significant role in the negative regulation of the amount and activity of YAP1 protein. Components of the Hippo pathway and YAP1 levels are frequently dysregulated in a variety of tumors, suggestive of their possible involvement in carcinogenesis. Our aim was to evaluate gene and protein expression profiles of YAP1, MST2 and LATS1 and the methylation status of MST2 and LATS1 promoters in ccRCC. mRNA levels of MST2, LATS1 and YAP1 genes were assessed in the tumor and matched normal kidney tissues of 86 patients, and in 12 samples of local metastases by quantitative PCR (qPCR). Proteins were semi-quantified in 58 patient samples by western blotting. Hypermethylation of LATS1 and MST2 promoters was measured by methylation‑specific high‑resolution-melting qPCR. We found that LATS1 promoter hypermethylation, decreased LATS1 mRNA/protein and increased YAP1 mRNA/protein levels in tumor samples were associated with higher TNM and Fuhrman's stages and patient survival. Higher YAP1 mRNA levels were associated with poor outcome (HR=4.03, p=0.036). No changes in MST2 (promoter/mRNA/protein) were found. We propose that deregulation of LATS1 and YAP1 expression is associated with ccRCC progression and poor patient survival. Measurement of YAP1 mRNA levels in paired tumor-normal kidney tissue samples may serve as a new prognostic factor in ccRCC.
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1 

Novara G, Martignoni G, Artibani W and Ficarra V: Grading systems in renal cell carcinoma. J Urol. 177:430–436. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Massari F, Bria E, Maines F, Milella M, Giannarelli D, Cognetti F, Pappagallo G, Tortora G and Porta C: Adjuvant treatment for resected renal cell carcinoma: Are all strategies equally negative? Potential implications for trial design with targeted agents. Clin Genitourin Cancer. 11:471–476. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Keizman D, Rouvinov K, Sella A, Gottfried M, Maimon N, Kim JJ, Eisenberger MA, Sinibaldi V, Peer A, Carducci MA, et al: Is there a ‘Trial Effect’ on outcome of patients with metastatic renal cell carcinoma treated with sunitinib? Cancer Res Treat. 48:281–287. 2016. View Article : Google Scholar : PubMed/NCBI

4 

van der Mijn JC, Mier JW, Broxterman HJ and Verheul HM: Predictive biomarkers in renal cell cancer: Insights in drug resistance mechanisms. Drug Resist Updat. 17:77–88. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Zhao B, Lei QY and Guan KL: The Hippo-YAP pathway: New connections between regulation of organ size and cancer. Curr Opin Cell Biol. 20:638–646. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Zhao B, Li L, Lei Q and Guan KL: The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version. Genes Dev. 24:862–874. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Liu H, Jiang D, Chi F and Zhao B: The Hippo pathway regulates stem cell proliferation, self-renewal, and differentiation. Protein Cell. 3:291–304. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Harvey KF, Zhang X and Thomas DM: The Hippo pathway and human cancer. Nat Rev Cancer. 13:246–257. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Zhao B, Tumaneng K and Guan KL: The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal. Nat Cell Biol. 13:877–883. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Halder G and Johnson RL: Hippo signaling: Growth control and beyond. Development. 138:9–22. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Moya IM and Halder G: The Hippo pathway in cellular reprogramming and regeneration of different organs. Curr Opin Cell Biol. 43:62–68. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wierzbicki PM and Rybarczyk A: The Hippo pathway in colorectal cancer. Folia Histochem Cytobiol. 53:105–119. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Janse van Rensburg HJ and Yang X: The roles of the Hippo pathway in cancer metastasis. Cell Signal. 28:1761–1772. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Johnson R and Halder G: The two faces of Hippo: Targeting the Hippo pathway for regenerative medicine and cancer treatment. Nat Rev Drug Discov. 13:63–79. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Cai J, Zhang N, Zheng Y, De Wilde RF, Maitra A and Pan D: The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 24:2383–2388. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Morinaga N, Shitara Y, Yanagita Y, Koida T, Kimura M, Asao T, Kimijima I, Takenoshita S, Hirota T, Saya H, et al: Molecular analysis of the h-warts/LATS1 gene in human breast cancer. Int J Oncol. 17:1125–1129. 2000.PubMed/NCBI

17 

Wierzbicki PM, Adrych K, Kartanowicz D, Stanislawowski M, Kowalczyk A, Godlewski J, Skwierz-Bogdanska I, Celinski K, Gach T, Kulig J, et al: Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation. World J Gastroenterol. 19:4363–4373. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Lin XY, Zhang XP, Wu JH, Qiu XS and Wang EH: Expression of LATS1 contributes to good prognosis and can negatively regulate YAP oncoprotein in non-small-cell lung cancer. Tumour Biol. 35:6435–6443. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, et al: Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 16:425–438. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Miyanaga A, Masuda M, Tsuta K, Kawasaki K, Nakamura Y, Sakuma T, Asamura H, Gemma A and Yamada T: Hippo pathway gene mutations in malignant mesothelioma: Revealed by RNA and targeted exon sequencing. J Thorac Oncol. 10:844–851. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Bora-Singhal N, Nguyen J, Schaal C, Perumal D, Singh S, Coppola D and Chellappan S: YAP1 regulates OCT4 activity and SOX2 expression to facilitate self-renewal and vascular mimicry of stem-like cells. Stem Cells. 33:1705–1718. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Machado-Neto JA, Lazarini M, Favaro P, Franchi GC Jr, Nowill AE, Saad ST and Traina F: ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells. Exp Cell Res. 324:137–145. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Vlug EJ, van de Ven RA, Vermeulen JF, Bult P, van Diest PJ and Derksen PW: Nuclear localization of the transcriptional coactivator YAP is associated with invasive lobular breast cancer. Cell Oncol (Dordr). 36:375–384. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Li M, Lu J, Zhang F, Li H, Zhang B, Wu X, Tan Z, Zhang L, Gao G, Mu J, et al: Yes-associated protein 1 (YAP1) promotes human gallbladder tumor growth via activation of the AXL/MAPK pathway. Cancer Lett. 355:201–209. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Liu YC and Wang YZ: Role of Yes-associated protein 1 in gliomas: Pathologic and therapeutic aspects. Tumour Biol. 36:2223–2227. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Klacz J, Wierzbicki PM, Wronska A, Rybarczyk A, Stanislawowski M, Slebioda T, Olejniczak A, Matuszewski M and Kmiec Z: Decreased expression of RASSF1A tumor suppressor gene is associated with worse prognosis in clear cell renal cell carcinoma. Int J Oncol. 48:55–66. 2016.PubMed/NCBI

27 

Wierzbicki PM, Klacz J, Rybarczyk A, Slebioda T, Stanislawowski M, Wronska A, Kowalczyk A, Matuszewski M and Kmiec Z: Identification of a suitable qPCR reference gene in metastatic clear cell renal cell carcinoma. Tumour Biol. 35:12473–12487. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Wojdacz TK and Dobrovic A: Methylation-sensitive high resolution melting (MS-HRM): A new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res. 35:e412007. View Article : Google Scholar : PubMed/NCBI

30 

Avădănei ER, Wierzbicki PM, Giuşcă SE, Grigoraş A, Amălinei C and Căruntu ID: Macrophage profile in primary versus secondary liver tumors. Folia Histochem Cytobiol. 52:112–123. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Sobin LH, Gospodarowicz MK and Wittekind C: International Union against Cancer: TNM classification of malignant tumours. Wiley-Blackwell; Chichester, West Sussex, UK; Hoboken, NJ: 2010

32 

Delahunt B, Sika-Paotonu D, Bethwaite PB, Jordan T William, Magi-Galluzzi C, Zhou M, Samaratunga H and Srigley JR: Grading of clear cell renal cell carcinoma should be based on nucleolar prominence. Am J Surg Pathol. 35:1134–1139. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Lin L, Sabnis AJ, Chan E, Olivas V, Cade L, Pazarentzos E, Asthana S, Neel D, Yan JJ, Lu X, et al: The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies. Nat Genet. 47:250–256. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhang L, Yang S, Chen X, Stauffer S, Yu F, Lele SM, Fu K, Datta K, Palermo N, Chen Y, et al: The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells. Mol Cell Biol. 35:1350–1362. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Mei L, Yuan L, Shi W, Fan S, Tang C, Fan X, Yang W, Qian Y, Hussain M and Wu X: SUMOylation of large tumor suppressor 1 at Lys751 attenuates its kinase activity and tumor-suppressor functions. Cancer Lett. 386:1–11. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Saucedo LJ and Edgar BA: Filling out the Hippo pathway. Nat Rev Mol Cell Biol. 8:613–621. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Yu FX, Zhao B and Guan KL: Hippo pathway in organ size control, tissue homeostasis, and cancer. Cell. 163:811–828. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Nokin MJ, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, Turtoi A, Costanza B, Smargiasso N, Baiwir D, et al: Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. eLife. 5:52016. View Article : Google Scholar

39 

Chen KH, He J, Wang DL, Cao JJ, Li MC, Zhao XM, Sheng X, Li WB and Liu WJ: Methylation associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma. Int J Oncol. 45:2511–2521. 2014.PubMed/NCBI

40 

Zhang H, Geng D, Gao J, Qi Y, Shi Y, Wang Y, Jiang Y, Zhang Y, Fu J, Dong Y, et al: Expression and significance of Hippo/YAP signaling in glioma progression. Tumour Biol. 37:15665–15676. 2016. View Article : Google Scholar

41 

He J, Tang F, Liu L, Chen L, Li J, Ou D, Zhang L, Li Z, Feng D, Li W, et al: Positive regulation of TAZ expression by EBV-LMP1 contributes to cell proliferation and epithelial-mesenchymal transition in nasopharyngeal carcinoma. Oncotarget. Dec 2–2016.(Epub ahead of print). doi.org/10.18632/oncotarget.13775. View Article : Google Scholar

42 

Jiang Z, Li X, Hu J, Zhou W, Jiang Y, Li G and Lu D: Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res. 56:450–458. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Sasaki H, Hikosaka Y, Kawano O, Yano M and Fujii Y: Hypermethylation of the large tumor suppressor genes in Japanese lung cancer. Oncol Lett. 1:303–307. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Oh JE, Ohta T, Satomi K, Foll M, Durand G, McKay J, Le Calvez-Kelm F, Mittelbronn M, Brokinkel B, Paulus W, et al: Alterations in the NF2/LATS1/LATS2/YAP pathway in schwannomas. J Neuropathol Exp Neurol. 74:952–959. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Reddy VR, Annamalai T, Narayanan V and Ramanathan A: Hypermethylation of promoter region of LATS1 - a CDK interacting protein in oral squamous cell carcinomas - a pilot study in India. Asian Pac J Cancer Prev. 16:1599–1603. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Karamitopoulou E, Zlobec I, Patsouris E, Peros G and Lugli A: Loss of E-cadherin independently predicts the lymph node status in colorectal cancer. Pathology. 43:133–137. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Li L, Fang R, Liu B, Shi H, Wang Y, Zhang W, Zhang X and Ye L: Deacetylation of tumor-suppressor MST1 in Hippo pathway induces its degradation through HBXIP-elevated HDAC6 in promotion of breast cancer growth. Oncogene. 35:4048–4057. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Rawat SJ and Chernoff J: Regulation of mammalian Ste20 (Mst) kinases. Trends Biochem Sci. 40:149–156. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Liang K, Zhou G, Zhang Q, Li J and Zhang C: Expression of hippo pathway in colorectal cancer. Saudi J Gastroenterol. 20:188–194. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Seidel C, Schagdarsurengin U, Blümke K, Würl P, Pfeifer GP, Hauptmann S, Taubert H and Dammann R: Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol Carcinog. 46:865–871. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Piccolo S, Dupont S and Cordenonsi M: The biology of YAP/TAZ: Hippo signaling and beyond. Physiol Rev. 94:1287–1312. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Plouffe SW, Hong AW and Guan KL: Disease implications of the Hippo/YAP pathway. Trends Mol Med. 21:212–222. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E, Dawson D, Willis JE, Markowitz SD, Camargo FD, et al: Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci USA. 108:E1312–E1320. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Cao JJ, Zhao XM, Wang DL, Chen KH, Sheng X, Li WB, Li MC, Liu WJ and He J: YAP is overexpressed in clear cell renal cell carcinoma and its knockdown reduces cell proliferation and induces cell cycle arrest and apoptosis. Oncol Rep. 32:1594–1600. 2014.PubMed/NCBI

55 

Dong C, Wei KJ, Zhang WB, Sun H, Pan HY and Zhang L: LATS2 induced by TNF-alpha and inhibited cell proliferation and invasion by phosphorylating YAP in oral squamous cell carcinoma. J Oral Pathol Med. 44:475–481. 2015. View Article : Google Scholar : PubMed/NCBI

56 

He C, Lv X, Hua G, Lele SM, Remmenga S, Dong J, Davis JS and Wang C: YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene. 34:6040–6054. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Jerhammar F, Johansson AC, Ceder R, Welander J, Jansson A, Grafström RC, Söderkvist P and Roberg K: YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer. Oral Oncol. 50:832–839. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Konsavage WM Jr, Kyler SL, Rennoll SA, Jin G and Yochum GS: Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. J Biol Chem. 287:11730–11739. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Yuan H, Liu H, Liu Z, Zhu D, Amos CI, Fang S, Lee JE and Wei Q: Genetic variants in Hippo pathway genes YAP1TEAD1TEAD4 are associated with melanoma-specific survival. Int J Cancer. 137:638–645. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Zhao J, Li X, Yang Y, Zhu D, Zhang C, Liu D, Wu K and Zhao S: Effect of YAP1 silencing on esophageal cancer. Onco Targets Ther. 9:3137–3146. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Li P, Sun D, Li X, He Y, Li W, Zhao J, Wang Y, Wang H and Xin Y: Elevated expression of Nodal and YAP1 is associated with poor prognosis of gastric adenocarcinoma. J Cancer Res Clin Oncol. 142:1765–1773. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Liao T, Wen D, Ma B, Hu JQ, Qu N, Shi RL, Liu L, Guan Q, Li DS and Ji QH: Yes-associated protein 1 promotes papillary thyroid cancer cell proliferation by activating the ERK/MAPK signaling pathway. Oncotarget. Feb 14–2017.(Epub ahead of print). doi.org/10.18632/oncotarget.14319.

63 

Pan Y, Robertson G, Pedersen L, Lim E, Hernandez-Herrera A, Rowat AC, Patil SL, Chan CK, Wen Y, Zhang X, et al: miR-509-3p is clinically significant and strongly attenuates cellular migration and multi-cellular spheroids in ovarian cancer. Oncotarget. 7:25930–25948. 2016.PubMed/NCBI

64 

Xu R, Zeng G, Gao J, Ren Y, Zhang Z, Zhang Q, Zhao J, Tao H and Li D: miR-138 suppresses the proliferation of oral squamous cell carcinoma cells by targeting Yes-associated protein 1. Oncol Rep. 34:2171–2178. 2015.PubMed/NCBI

65 

Xiao L, Zhou H, Li XP, Chen J, Fang C, Mao CX, Cui JJ, Zhang W, Zhou HH, Yin JY, et al: MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1. Oncotarget. 7:40038–40046. 2016.PubMed/NCBI

66 

Lee KW, Lee SS, Kim SB, Sohn BH, Lee HS, Jang HJ, Park YY, Kopetz S, Kim SS, Oh SC, et al: Significant association of oncogene YAP1 with poor prognosis and cetuximab resistance in colorectal cancer patients. Clin Cancer Res. 21:357–364. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, et al: The Hippo coactivator YAP1 mediates EGFR overexpression and confers chemoresistance in esophageal cancer. Clin Cancer Res. 21:2580–2590. 2015. View Article : Google Scholar : PubMed/NCBI

68 

Touil Y, Igoudjil W, Corvaisier M, Dessein AF, Vandomme J, Monté D, Stechly L, Skrypek N, Langlois C, Grard G, et al: Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. Clin Cancer Res. 20:837–846. 2014. View Article : Google Scholar : PubMed/NCBI

69 

Wang DY, Wu YN, Huang JQ, Wang W, Xu M, Jia JP, Han G, Mao BB and Bi WZ: Hippo/YAP signaling pathway is involved in osteosarcoma chemoresistance. Chin J Cancer. 35:472016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Rybarczyk A, Klacz J, Wronska A, Matuszewski M, Kmiec Z and Wierzbicki PM: Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome. Oncol Rep 38: 427-439, 2017.
APA
Rybarczyk, A., Klacz, J., Wronska, A., Matuszewski, M., Kmiec, Z., & Wierzbicki, P.M. (2017). Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome. Oncology Reports, 38, 427-439. https://doi.org/10.3892/or.2017.5642
MLA
Rybarczyk, A., Klacz, J., Wronska, A., Matuszewski, M., Kmiec, Z., Wierzbicki, P. M."Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome". Oncology Reports 38.1 (2017): 427-439.
Chicago
Rybarczyk, A., Klacz, J., Wronska, A., Matuszewski, M., Kmiec, Z., Wierzbicki, P. M."Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome". Oncology Reports 38, no. 1 (2017): 427-439. https://doi.org/10.3892/or.2017.5642
Copy and paste a formatted citation
x
Spandidos Publications style
Rybarczyk A, Klacz J, Wronska A, Matuszewski M, Kmiec Z and Wierzbicki PM: Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome. Oncol Rep 38: 427-439, 2017.
APA
Rybarczyk, A., Klacz, J., Wronska, A., Matuszewski, M., Kmiec, Z., & Wierzbicki, P.M. (2017). Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome. Oncology Reports, 38, 427-439. https://doi.org/10.3892/or.2017.5642
MLA
Rybarczyk, A., Klacz, J., Wronska, A., Matuszewski, M., Kmiec, Z., Wierzbicki, P. M."Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome". Oncology Reports 38.1 (2017): 427-439.
Chicago
Rybarczyk, A., Klacz, J., Wronska, A., Matuszewski, M., Kmiec, Z., Wierzbicki, P. M."Overexpression of the YAP1 oncogene in clear cell renal cell carcinoma is associated with poor outcome". Oncology Reports 38, no. 1 (2017): 427-439. https://doi.org/10.3892/or.2017.5642
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