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Article

miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD

  • Authors:
    • Zhi-Qiang Xiao
    • Teng-Kun Yin
    • Ya-Xing Li
    • Jian-He Zhang
    • Jian-Jun Gu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The First People's Hospital of Shangqiu, Shangqiu, Henan 476100, P.R. China, Department of Neurosurgery, Fuzong Clinical College, Fujian Medical University, Fuzhou, Fujian 350025, P.R. China, Department of Oncology, Taizhou People's Hospital Affiliated to the Medical College of Nantong University, Taizhou, Jiangsu 225300, P.R. China, Stroke Center, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, P.R. China
  • Pages: 167-174
    |
    Published online on: May 19, 2017
       https://doi.org/10.3892/or.2017.5651
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Abstract

MicroRNAs are short non-coding RNAs that play important roles in gliomas. However, the role of miR-130b in glioma remains unclear. In the present study, miR-130b expression was upregulated in glioma tissues and cell lines. Kaplan-Meier analysis indicated that the upregulation of miR-130b expression correlated with poor prognoses in glioma patients. Multivariate analysis demonstrated that this upregulation and a high-grade classification were independent factors that both predicted poor outcomes for glioma patients. Dual-luciferase assays identified that the cylindromatosis (CYLD) gene is a direct target of miR-130b. Functional studies demonstrated that a miR-130b mimic significantly promoted the growth and invasion of glioma cells, while also inhibiting apoptosis via selective targeting of CYLD, which was enhanced by CYLD-targeted siRNA. In contrast, a miR‑130b inhibitor suppressed these biological behaviors, and this inhibition was reversed by CYLD-targeted siRNA. These data revealed that miR-130b could act as a novel potential diagnostic biomarker for glioma, while also demonstrating the importance of miR‑130b in the cell proliferation and progression of glioma, indicating that it may serve as a useful therapeutic target for glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao Z, Yin T, Li Y, Zhang J and Gu J: miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD. Oncol Rep 38: 167-174, 2017.
APA
Xiao, Z., Yin, T., Li, Y., Zhang, J., & Gu, J. (2017). miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD. Oncology Reports, 38, 167-174. https://doi.org/10.3892/or.2017.5651
MLA
Xiao, Z., Yin, T., Li, Y., Zhang, J., Gu, J."miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD". Oncology Reports 38.1 (2017): 167-174.
Chicago
Xiao, Z., Yin, T., Li, Y., Zhang, J., Gu, J."miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD". Oncology Reports 38, no. 1 (2017): 167-174. https://doi.org/10.3892/or.2017.5651
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao Z, Yin T, Li Y, Zhang J and Gu J: miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD. Oncol Rep 38: 167-174, 2017.
APA
Xiao, Z., Yin, T., Li, Y., Zhang, J., & Gu, J. (2017). miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD. Oncology Reports, 38, 167-174. https://doi.org/10.3892/or.2017.5651
MLA
Xiao, Z., Yin, T., Li, Y., Zhang, J., Gu, J."miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD". Oncology Reports 38.1 (2017): 167-174.
Chicago
Xiao, Z., Yin, T., Li, Y., Zhang, J., Gu, J."miR-130b regulates the proliferation, invasion and apoptosis of glioma cells via targeting of CYLD". Oncology Reports 38, no. 1 (2017): 167-174. https://doi.org/10.3892/or.2017.5651
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