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Article

New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity

  • Authors:
    • Xian Li
    • Huijun Wu
    • Xiaohui Ouyang
    • Bo Zhang
    • Xiulan Su
  • View Affiliations / Copyright

    Affiliations: Clinical Medical Research Center, The Affiliated Hospital, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, P.R. China, Department of Hepatobiliary Pancreatic Surgery, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia 010010, P.R. China
  • Pages: 129-140
    |
    Published online on: May 26, 2017
       https://doi.org/10.3892/or.2017.5674
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Abstract

Anticancer bioactive peptide (ACBP) is extracted from normal goat spleens and exhibits antitumor activity alone and in combination with low cisplatin doses to achieve antitumor efficacy similar to higher cisplatin doses via sustained medication modes. In the present study, we investigated whether elevated levels of induced or normal ACBP in MKN‑45 gastric cancer (GC) cells may reduce their toxicity to oxaliplatin (L‑OHP) in a dose‑dependent manner. The growth inhibition rate (IR), morphological changes and gene expression were examined in MKN‑45 GC cells. Compared with normal ACBP, induced ACBP alone significantly enhanced the anticancer activity of L‑OHP‑mediated apoptosis and reduced the amount and side‑effects of L‑OHP (P<0.05). The inhibition of cancer cell growth at high concentrations of induced ACBP and L‑OHP was significantly more effective than at low concentrations. In addition, for the first time, we examined the potential of a combination of induced ACBP and L‑OHP to increase L‑OHP sensitivity in human gastric carcinoma xenograft tumors. Nude mice were implanted with human gastric carcinoma MKN‑45 cells and treated with an intraperitoneal injection of 0.5 ml of normal saline, 30 µg/ml ACBP, 20 µg/ml L‑OHP or 30 µg/ml ACBP + 20 µg/ml L‑OHP [combination of anticancer bioactive peptide and oxaliplatin (A+L)] via the tail vein twice a week. In vivo short‑term intermittent use of induced ACBP alone significantly inhibited MKN‑45 tumor growth. The combination of induced ACBP and L‑OHP also significantly improved the quality of life of the nude mice and reduced the toxicity of L‑OHP. Based on flow cytometry and gene expression analyses, A+L significantly increased the proportion of cells in the G2/M phase (P<0.05) relative to ACBP or L‑OHP alone, and short‑term intraperitoneal injection of ACBP increased the sensitizing effect of L‑OHP. Collectively, these results suggest that high levels of induced ACBP in combination with L‑OHP via a short‑term intermittent medication mode could be a useful clinical therapeutic strategy for GC.
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1 

Kassam Z, Mackay H, Buckley CA, Fung S, Pintile M, Kim J and Ringash J: Evaluating the impact on quality of life of chemoradiation in gastric cancer. Curr Oncol. 17:77–84. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Chen XZ, Zhang WH and Hu JK: A difficulty in improving population survival outcome of gastric cancer in mainland China: Low proportion of early diseases. Med Oncol. 31:3152014. View Article : Google Scholar : PubMed/NCBI

3 

Ye L, Zhang ZY, Du WD, Schneider ME, Qiu Y, Zhou Y, Zhou FS, Zuo XB, Chen G, Ma XL, et al: Genetic analysis of ADIPOQ variants and gastric cancer risk: A hospital-based case-control study in China. Med Oncol. 30:6582013. View Article : Google Scholar : PubMed/NCBI

4 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Fock KM: Review article: The epidemiology and prevention of gastric cancer. Aliment Pharmacol Ther. 40:250–260. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Soulié P, Bensmaïne A, Garrino C, Chollet P, Brain E, Fereres M, Jasmin C, Musset M, Misset JL and Cvitkovic E: Oxaliplatin/cisplatin (L-OHP/CDDP) combination in heavily pretreated ovarian cancer. Eur J Cancer. 33:1400–1406. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Dong HL and Chen M: GEM combination 5-Fu/L-OHP treatment of advanced pancreatic cancer, effect observation of 47 cases. Mod Prev Med. 35:3872–3873. 2008.

8 

Zhang C, Ren Z and Li C: Recent effect of combination chemotherapy of hydroxycamptothecin and 5-FU, MMC for advanced pancreatic cancer. Guangzhou Med J. 34:38–39. 2003.

9 

Rebucci M and Michiels C: Molecular aspects of cancer cell resistance to chemotherapy. Biochem Pharmacol. 85:1219–1226. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Cervantes A, Roselló S, Roda D and Rodríguez-Braun E: The treatment of advanced gastric cancer: Current strategies and future perspectives. Ann Oncol. 19 Suppl 5:v103–v107. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Yoong J, Michael M and Leong T: Targeted therapies for gastric cancer: Current status. Drugs. 71:1367–1384. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Mathé G, Kidani Y, Noji M, Maral R, Bourut C and Chenu E: Antitumor activity of l-OHP in mice. Cancer Lett. 27:135–143. 1985. View Article : Google Scholar : PubMed/NCBI

13 

Degardin M, Cappelaere P, Krakowski I, Fargeot P, Cupissol D and Brienza S: Phase II trial of oxaliplatin (L-OHP) in advanced, recurrent and/or metastatic squamous cell carcinoma of the head and neck. Eur J Cancer B Oral Oncol. 32B:278–279. 1996. View Article : Google Scholar : PubMed/NCBI

14 

Fiteni F, Nguyen T, Vernerey D, Paillard MJ, Kim S, Demarchi M, Fein F, Borg C, Bonnetain F and Pivot X: Cisplatin/gemcitabine or oxaliplatin/gemcitabine in the treatment of advanced biliary tract cancer: A systematic review. Cancer Med. 3:1502–1511. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Zhang C, Jia S and Su X: Effect of anticancer bioactive peptide on the gene expression of human gastric cancer BGC-823 cells. J Clin Oncol. 37:1021–1023. 2010.

16 

Wen ZH and Su XL: The effect of anti-cancer bioactive peptide on the expression of p53 and Bcl-2 of tumor tissues of experimental nude mice. Med Rev. 17:1557–1559. 2011.

17 

Su X, Dong C, Zhang J, Su L, Wang X, Cui H and Chen Z: Combination therapy of anti-cancer bioactive peptide with Cisplatin decreases chemotherapy dosing and toxicity to improve the quality of life in xenograft nude mice bearing human gastric cancer. Cell Biosci. 4:72014. View Article : Google Scholar : PubMed/NCBI

18 

Sui CG, Meng FD, Li Y and Jiang YH: Antiproliferative activity of rosamultic acid is associated with induction of apoptosis, cell cycle arrest, inhibition of cell migration and caspase activation in human gastric cancer (SGC-7901) cells. Phytomedicine. 22:796–806. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Tu K, Zheng X, Zhou Z, Li C, Zhang J, Gao J, Yao Y and Liu Q: Recombinant human adenovirus-p53 injection induced apoptosis in hepatocellular carcinoma cell lines mediated by p53-Fbxw7 pathway, which controls c-Myc and cyclin E. PLoS One. 8:e685742013. View Article : Google Scholar : PubMed/NCBI

21 

Yao HJ, Zhang YG, Sun L and Liu Y: The effect of hyaluronic acid functionalized carbon nanotubes loaded with salinomycin on gastric cancer stem cells. Biomaterials. 35:9208–9223. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Wang J, Chen X, Su L, Li P, Cai Q, Liu B, Wu W and Zhu Z: MicroRNA-126 inhibits cell proliferation in gastric cancer by targeting LAT-1. Biomed Pharmacother. 72:66–73. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Tu K, Zheng X, Zan X, Han S, Yao Y and Liu Q: Evaluation of Fbxw7 expression and its correlation with the expression of c-Myc, cyclin E and p53 in human hepatocellular carcinoma. Hepatol Res. 42:904–910. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Yin T, Lu L, Xiong Z, Wei S and Cui D: ATPase inhibitory factor 1 is a prognostic marker and contributes to proliferation and invasion of human gastric cancer cells. Biomed Pharmacother. 70:90–96. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Stacul F, Bertolotto M, De Gobbis F, Calderan L, Cioffi V, Romano A, Zanconati F and Cova MA: US, colour-Doppler US and fine-needle aspiration biopsy in the diagnosis of thyroid nodules. Radiol Med (Torino). 112:751–762. 2007. View Article : Google Scholar

26 

Yu L, Yang L, An W and Su X: Anticancer bioactive peptide-3 inhibits human gastric cancer growth by suppressing gastric cancer stem cells. J Cell Biochem. 115:697–711. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Su L, Xu G, Shen J, Tuo Y, Zhang X, Jia S, Chen Z and Su X: Anticancer bioactive peptide suppresses human gastric cancer growth through modulation of apoptosis and the cell cycle. Oncol Rep. 23:3–9. 2010.PubMed/NCBI

28 

Kundu T, Dey S, Roy M, Siddiqi M and Bhattacharya RK: Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. Cancer Lett. 230:111–121. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Alshatwi AA, Athinarayanan J and Periasamy VS: Green synthesis of bimetallic Au@Pt nanostructures and their application for proliferation inhibition and apoptosis induction in human cervical cancer cell. J Mater Sci Mater Med. 26:1482015. View Article : Google Scholar : PubMed/NCBI

30 

Khoo BY, Chua SL and Balaram P: Apoptotic effects of chrysin in human cancer cell lines. Int J Mol Sci. 11:2188–2199. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Li W, Wang J, Jiang HR, Xu XL, Zhang J, Liu ML and Zhai LY: Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo. Int J Mol Sci. 12:668–681. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Pietenpol JA and Stewart ZA: Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis. Toxicology. 181–182. 2002.PubMed/NCBI

33 

Xiang Z, Kang QJ and Xiang X: Gene and protein expression in the oxaliplatin-resistant HT29/L-OHP human colon cancer cell line. Genet Mol Res. 14:11013–11022. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Reubold TF and Eschenburg S: A molecular view on signal transduction by the apoptosome. Cell Signal. 24:1420–1425. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Huang L, Zhang T, Li S, Duan J, Ye F, Li H, She Z, Gao G and Yang X: Anthraquinone G503 induces apoptosis in gastric cancer cells through the mitochondrial pathway. PLoS One. 9:e1082862014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wu H, Ouyang X, Zhang B and Su X: New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity. Oncol Rep 38: 129-140, 2017.
APA
Li, X., Wu, H., Ouyang, X., Zhang, B., & Su, X. (2017). New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity. Oncology Reports, 38, 129-140. https://doi.org/10.3892/or.2017.5674
MLA
Li, X., Wu, H., Ouyang, X., Zhang, B., Su, X."New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity". Oncology Reports 38.1 (2017): 129-140.
Chicago
Li, X., Wu, H., Ouyang, X., Zhang, B., Su, X."New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity". Oncology Reports 38, no. 1 (2017): 129-140. https://doi.org/10.3892/or.2017.5674
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wu H, Ouyang X, Zhang B and Su X: New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity. Oncol Rep 38: 129-140, 2017.
APA
Li, X., Wu, H., Ouyang, X., Zhang, B., & Su, X. (2017). New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity. Oncology Reports, 38, 129-140. https://doi.org/10.3892/or.2017.5674
MLA
Li, X., Wu, H., Ouyang, X., Zhang, B., Su, X."New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity". Oncology Reports 38.1 (2017): 129-140.
Chicago
Li, X., Wu, H., Ouyang, X., Zhang, B., Su, X."New bioactive peptide reduces the toxicity of chemotherapy drugs and increases drug sensitivity". Oncology Reports 38, no. 1 (2017): 129-140. https://doi.org/10.3892/or.2017.5674
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