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Article

Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma

  • Authors:
    • Yu Zhao
    • Li Min
    • Changqin Xu
    • Linlin Shao
    • Shuilong Guo
    • Rui Cheng
    • Jie Xing
    • Shengtao Zhu
    • Shutian Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesions of Digestive Disease, Xicheng, Beijing 100050, P.R. China
  • Pages: 411-417
    |
    Published online on: May 30, 2017
       https://doi.org/10.3892/or.2017.5681
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Abstract

Even though various molecules may serve as biomarkers, little is known concerning the mechanisms underlying the carcinogenesis of ESCC, particularly the transcriptional regulatory network. Thus, in the present study, paired ESCC and non-cancerous (NC) tissues were assayed by Affymetrix microarray assays. Passing Attributes between Networks for Data Assimilation (PANDA) was used to construct networks between transcription factors (TFs) and their targets. AnaPANDA program was applied to compare the regulatory networks. A hypergeometric distribution model-based target profile similarity analysis was utilized to find co-activation effects using both TF-target networks and differential expression data. There were 1,116 genes upregulated and 1,301 genes downregulated in ESCC compared with NC tissues. In TF-target networks, 16,970 ESCC-specific edges and 9,307 NC-specific edges were identified. Edge enrichment analysis by AnaPANDA indicated 17 transcription factors (NFE2L2, ELK4, PAX6, TLX1, ESR1, ZNF143, TP53, REL, ELF5, STAT1, TBP, NHLH1, FOXL1, SOX9, STAT3, ELK1, and HOXA5) suppressed in ESCC and 5 (SPIB, BRCA1, MZF1, MAFG and NFE2L1) activated in ESCC. For SPIB, MZF1, MAFG and NFE2L1, a strong and significant co-activation effect among them was detected in ESCC. In conclusion, the construction of transcriptional regulatory networks found SPIB, MZF1, MAFG and NFE2L1 co-activated in ESCC, which provides distinctive insight into the carcinogenesis mechanism of ESCC.
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1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zhu HC, Yang X, Xu LP, Zhao LJ, Tao GZ, Zhang C, Qin Q, Cai J, Ma JX, Mao WD, et al: Meat consumption is associated with esophageal cancer risk in a meat- and cancer-histological-type dependent manner. Dig Dis Sci. 59:664–673. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: Defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol. 24:2137–2150. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Chen M, Huang J, Zhu Z, Zhang J and Li K: Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer. BMC Cancer. 13:5392013. View Article : Google Scholar : PubMed/NCBI

5 

Guo M, Ren J, House MG, Qi Y, Brock MV and Herman JG: Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus. Clin Cancer Res. 12:4515–4522. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Jia Y, Yang Y, Zhan Q, Brock MV, Zheng X, Yu Y, Herman JG and Guo M: Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer. J Mol Diagn. 14:577–585. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Wu L, Herman JG, Brock MV, Wu K, Mao G, Yan W, Nie Y, Liang H, Zhan Q, Li W, et al: Silencing DACH1 promotes esophageal cancer growth by inhibiting TGF-β signaling. PLoS One. 9:e955092014. View Article : Google Scholar : PubMed/NCBI

8 

Guo M, Ren J, Brock MV, Herman JG and Carraway HE: Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. Epigenetics. 3:336–341. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Jia Y, Yang Y, Brock MV, Cao B, Zhan Q, Li Y, Yu Y, Herman JG and Guo M: Methylation of TFPI-2 is an early event of esophageal carcinogenesis. Epigenomics. 4:135–146. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Wang JS, Guo M, Montgomery EA, Thompson RE, Cosby H, Hicks L, Wang S, Herman JG and Canto MI: DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus. Am J Gastroenterol. 104:2153–2160. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Yun T, Liu Y, Gao D, Linghu E, Brock MV, Yin D, Zhan Q, Herman JG and Guo M: Methylation of CHFR sensitizes esophageal squamous cell cancer to docetaxel and paclitaxel. genes. Cancer. 6:38–48. 2015.

12 

Rong R, Jiang LY, Sheikh MS and Huang Y: Mitotic kinase Aurora-A phosphorylates RASSF1A and modulates RASSF1A-mediated microtubule interaction and M-phase cell cycle regulation. Oncogene. 26:7700–7708. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Mori M and Croce CM: Promoter hypermethylation of RASSF1A in esophageal squamous cell carcinoma. Clin Cancer Res. 9:1441–1445. 2003.PubMed/NCBI

14 

Maesawa C, Tamura G, Nishizuka S, Ogasawara S, Ishida K, Terashima M, Sakata K, Sato N, Saito K and Satodate R: Inactivation of the CDKN2 gene by homozygous deletion and de novo methylation is associated with advanced stage esophageal squamous cell carcinoma. Cancer Res. 56:3875–3878. 1996.PubMed/NCBI

15 

Lee EJ, Lee BB, Kim JW, Shim YM, Hoseok I, Han J, Cho EY, Park J and Kim DH: Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinoma. Eur J Cancer. 42:972–980. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Barabási AL: Network medicine - from obesity to the ‘diseasome’. N Engl J Med. 357:404–407. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Silverman EK and Loscalzo J: Developing new drug treatments in the era of network medicine. Clin Pharmacol Ther. 93:26–28. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Silverman EK and Loscalzo J: Network medicine approaches to the genetics of complex diseases. Discov Med. 14:143–152. 2012.PubMed/NCBI

19 

Papin JA, Reed JL and Palsson BO: Hierarchical thinking in network biology: The unbiased modularization of biochemical networks. Trends Biochem Sci. 29:641–647. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Glass K, Quackenbush J, Spentzos D, Haibe-Kains B and Yuan GC: A network model for angiogenesis in ovarian cancer. BMC Bioinformatics. 16:1152015. View Article : Google Scholar : PubMed/NCBI

21 

Lao T, Glass K, Qiu W, Polverino F, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, et al: Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 7:122015. View Article : Google Scholar : PubMed/NCBI

22 

Xu CQ, Zhu ST, Wang M, Guo SL, Sun XJ, Cheng R, Xing J, Wang WH, Shao LL and Zhang ST: Pathway analysis of differentially expressed genes in human esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 19:1652–1661. 2015.PubMed/NCBI

23 

Banks CA, Lee ZT, Boanca G, Lakshminarasimhan M, Groppe BD, Wen Z, Hattem GL, Seidel CW, Florens L and Washburn MP: Controlling for gene expression changes in transcription factor protein networks. Mol Cell Proteomics. 13:1510–1522. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Buckingham M and Rigby PW: Gene regulatory networks and transcriptional mechanisms that control myogenesis. Dev Cell. 28:225–238. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Glass K, Quackenbush J, Silverman EK, Celli B, Rennard SI, Yuan GC and DeMeo DL: Sexually-dimorphic targeting of functionally-related genes in COPD. BMC Syst Biol. 8:1182014. View Article : Google Scholar : PubMed/NCBI

26 

Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS and Kaushansky K: A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells. J Biol Chem. 266:14183–14187. 1991.PubMed/NCBI

27 

Deng Y, Wang J, Wang G, Jin Y, Luo X, Xia X, Gong J and Hu J: p55PIK transcriptionally activated by MZF1 promotes colorectal cancer cell proliferation. Biomed Res Int. 2013:8681312013. View Article : Google Scholar : PubMed/NCBI

28 

Zheng L, Jiao W, Mei H, Song H, Li D, Xiang X, Chen Y, Yang F, Li H, Huang K, et al: miRNA-337-3p inhibits gastric cancer progression through repressing myeloid zinc finger 1-facilitated expression of matrix metalloproteinase 14. Oncotarget. 7:40314–40328. 2016.PubMed/NCBI

29 

Tsai SJ, Hwang JM, Hsieh SC, Ying TH and Hsieh YH: Overexpression of myeloid zinc finger 1 suppresses matrix metalloproteinase-2 expression and reduces invasiveness of SiHa human cervical cancer cells. Biochem Biophys Res Commun. 425:462–467. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Katsuoka F and Yamamoto M: Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. 586:197–205. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Yang YM, Roh YS, Seki E and Maf G: MafG, a novel target of FXR that regulates bile acid homeostasis. Gastroenterology. 149:1981–1983. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Ding X, Yang Y, Han B, Du C, Xu N, Huang H, Cai T, Zhang A, Han ZG, Zhou W, et al: Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation. PLoS One. 9:e953072014. View Article : Google Scholar : PubMed/NCBI

33 

No authors listed: MAFG mediates CIMP in BRAF-mutant colorectal cancer. Cancer Discov. 4:OF112014. View Article : Google Scholar

34 

Rui L, Schmitz R, Ceribelli M and Staudt LM: Malignant pirates of the immune system. Nat Immunol. 12:933–940. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Lenz G, Wright GW, Emre NC, Kohlhammer H, Dave SS, Davis RE, Carty S, Lam LT, Shaffer AL, Xiao W, et al: Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci USA. 105:13520–13525. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, et al: Spi-B is critical for plasmacytoid dendritic cell function and development. Blood. 120:4733–4743. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Schmidlin H, Diehl SA, Nagasawa M, Scheeren FA, Schotte R, Uittenbogaart CH, Spits H and Blom B: Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression. Blood. 112:1804–1812. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Schotte R, Nagasawa M, Weijer K, Spits H and Blom B: The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med. 200:1503–1509. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Takagi Y, Shimada K, Shimada S, Sakamoto A, Naoe T, Nakamura S, Hayakawa F, Tomita A and Kiyoi H: SPIB is a novel prognostic factor in diffuse large B-cell lymphoma that mediates apoptosis via the PI3K-AKT pathway. Cancer Sci. 107:1270–1280. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Zhang Y and Manning BD: mTORC1 signaling activates NRF1 to increase cellular proteasome levels. Cell Cycle. 14:2011–2017. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Kim HM, Han JW and Chan JY: Nuclear factor erythroid-2 like 1 (NFE2L1): Structure, function and regulation. Gene. 584:17–25. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Min L, Xu C, Shao L, Guo S, Cheng R, Xing J, Zhu S and Zhang S: Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma. Oncol Rep 38: 411-417, 2017.
APA
Zhao, Y., Min, L., Xu, C., Shao, L., Guo, S., Cheng, R. ... Zhang, S. (2017). Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma. Oncology Reports, 38, 411-417. https://doi.org/10.3892/or.2017.5681
MLA
Zhao, Y., Min, L., Xu, C., Shao, L., Guo, S., Cheng, R., Xing, J., Zhu, S., Zhang, S."Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma". Oncology Reports 38.1 (2017): 411-417.
Chicago
Zhao, Y., Min, L., Xu, C., Shao, L., Guo, S., Cheng, R., Xing, J., Zhu, S., Zhang, S."Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma". Oncology Reports 38, no. 1 (2017): 411-417. https://doi.org/10.3892/or.2017.5681
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Min L, Xu C, Shao L, Guo S, Cheng R, Xing J, Zhu S and Zhang S: Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma. Oncol Rep 38: 411-417, 2017.
APA
Zhao, Y., Min, L., Xu, C., Shao, L., Guo, S., Cheng, R. ... Zhang, S. (2017). Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma. Oncology Reports, 38, 411-417. https://doi.org/10.3892/or.2017.5681
MLA
Zhao, Y., Min, L., Xu, C., Shao, L., Guo, S., Cheng, R., Xing, J., Zhu, S., Zhang, S."Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma". Oncology Reports 38.1 (2017): 411-417.
Chicago
Zhao, Y., Min, L., Xu, C., Shao, L., Guo, S., Cheng, R., Xing, J., Zhu, S., Zhang, S."Construction of disease-specific transcriptional regulatory networks identifies co-activation of four gene in esophageal squamous cell carcinoma". Oncology Reports 38, no. 1 (2017): 411-417. https://doi.org/10.3892/or.2017.5681
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