MicroRNA-605 functions as a tumor suppressor by targeting INPP4B in melanoma

  • Authors:
    • Lan Chen
    • Yaxuan Cao
    • Dongyun Rong
    • Ye Wang
    • Yu Cao
  • View Affiliations

  • Published online on: June 22, 2017     https://doi.org/10.3892/or.2017.5740
  • Pages: 1276-1286
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Abstract

MicroRNAs (miRNAs) play crucial roles in the initiation and progression of various cancers, including melanoma. Recently, the genetic variants and deregulation of miR-605 have been reported to participate in carcinogenesis. However, the expression status of the miR-605 in melanoma tissues and its role in melanoma progression remain unknown. In this study, we found that miR-605 was significantly downregulated in melanoma cell lines and clinical specimens. Further function studies demonstrated that miR-605 suppressed melanoma cell growth both in vitro and in vivo. Moreover, INPP4B gene was identified as a target of miR-605 through bioinformatics analysis and luciferase reporter assays. Further analysis demonstrated that the inhibition of INPP4B mediated SGK3 activation was required for the suppressive role of miR-605 on melanomas cell growth. Collectively, our data suggest that miR-605 functions as a tumor suppressor by negatively regulating INPP4B mediated SGK3 activation in melanoma and may present a potential target for therapeutic intervention.
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August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Chen L, Cao Y, Rong D, Wang Y and Cao Y: MicroRNA-605 functions as a tumor suppressor by targeting INPP4B in melanoma. Oncol Rep 38: 1276-1286, 2017
APA
Chen, L., Cao, Y., Rong, D., Wang, Y., & Cao, Y. (2017). MicroRNA-605 functions as a tumor suppressor by targeting INPP4B in melanoma. Oncology Reports, 38, 1276-1286. https://doi.org/10.3892/or.2017.5740
MLA
Chen, L., Cao, Y., Rong, D., Wang, Y., Cao, Y."MicroRNA-605 functions as a tumor suppressor by targeting INPP4B in melanoma". Oncology Reports 38.2 (2017): 1276-1286.
Chicago
Chen, L., Cao, Y., Rong, D., Wang, Y., Cao, Y."MicroRNA-605 functions as a tumor suppressor by targeting INPP4B in melanoma". Oncology Reports 38, no. 2 (2017): 1276-1286. https://doi.org/10.3892/or.2017.5740