Open Access

Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions

  • Authors:
    • Dongjing Lin
    • Yaxiong Guo
    • Yanru Li
    • Yang Ruan
    • Mingzi Zhang
    • Xiangshu Jin
    • Minlan Yang
    • Yan Lu
    • Peiye Song
    • Shuai Zhao
    • Bing Dong
    • Yinping Xie
    • Qihua Dang
    • Chengshi Quan
  • View Affiliations

  • Published online on: June 27, 2017     https://doi.org/10.3892/or.2017.5756
  • Pages: 875-885
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Claudin-6 (CLDN6) is an integral component of the tight junction proteins in polarized epithelial and endothelial cells and plays a crucial role in maintaining cell integrity. Deregulation of CLDN6 expression and distribution in tumor tissues have been widely documented and correlated with cancer progression and metastasis. However, a complete mechanistic understanding of CLDN6 regulation and function remains to be studied. Herein, we show new potential properties of CLDN6 regulation and functions from bioinformatics analysis. Using numerous algorithms to characterize the CLDN6 gene promoter elements and the CLDN6 protein structure, physio-chemical and localization properties, and its evolutionary relationships. CLDN6 is regulated by a diverse set of transcription factors (SP1, SPR, AML-1a, CdxA, CRE-BP and CREB) and associated with the levels of methylation of CpG islands in promoters. The structural properties of CLDN6 indicate that it promotes cancer cell behavior via the ASK1-p38/JNK MAPK secretory signaling pathway. In conclusion, this information from bioinformatics analysis will help future attempts to better understand CLDN6 regulation and functions.
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August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Lin D, Guo Y, Li Y, Ruan Y, Zhang M, Jin X, Yang M, Lu Y, Song P, Zhao S, Zhao S, et al: Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions. Oncol Rep 38: 875-885, 2017
APA
Lin, D., Guo, Y., Li, Y., Ruan, Y., Zhang, M., Jin, X. ... Quan, C. (2017). Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions. Oncology Reports, 38, 875-885. https://doi.org/10.3892/or.2017.5756
MLA
Lin, D., Guo, Y., Li, Y., Ruan, Y., Zhang, M., Jin, X., Yang, M., Lu, Y., Song, P., Zhao, S., Dong, B., Xie, Y., Dang, Q., Quan, C."Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions". Oncology Reports 38.2 (2017): 875-885.
Chicago
Lin, D., Guo, Y., Li, Y., Ruan, Y., Zhang, M., Jin, X., Yang, M., Lu, Y., Song, P., Zhao, S., Dong, B., Xie, Y., Dang, Q., Quan, C."Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions". Oncology Reports 38, no. 2 (2017): 875-885. https://doi.org/10.3892/or.2017.5756