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Article

Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma

  • Authors:
    • Qiao-Li Lv
    • Hong Du
    • Yan-Ling Liu
    • Yuang-Tao Huang
    • Gui-Hua Wang
    • Xue Zhang
    • Shu-Hui Chen
    • Hong-Hao Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Science and Education, Jiangxi Key Laboratory of Translational Cancer Research, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China, Department of Pharmacy, Qingdao Mental Health Center, Qingdao, Shandong 266034, P.R. China, Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Neurology, The Brain Hospital of Hunan Province, Changsha, Hunan 410008, P.R. China, Department of Oncology, Changsha Central Hospital, Changsha, Hunan 410008, P.R. China, Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China
  • Pages: 959-966
    |
    Published online on: June 28, 2017
       https://doi.org/10.3892/or.2017.5762
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Abstract

Accumulating evidence demonstrates that dysregulated microRNAs (miRNAs) play a critical role in tumorigenesis and progression of various cancers. miR-320b, a member of miR‑320 family, was revealed downregulated in numerous human cancers, including nasopharyngeal carcinoma and colorectal cancer. However, the function of miR‑320b in human glioma remained poorly defined. In this study, we report that miR‑320b was lowly expressed in glioma tissues and cell lines in contrast with controls, being closely correlated with histological malignancy of glioma. Furthermore, patients with low expression of miR‑320b were associated with poor prognostic outcomes. In vitro functional assays indicated that overexpression of miR‑320b could markedly enhance cell apoptosis rate and suppress cell proliferation, migration and invasion. miR-320b mimic impaired cell cycle and metastasis through inhibiting the expression of G1/S transition key regulator Cyclin D1 as well as decreasing the expression level of MMP2 and MMP9. Additionally, upregulation of miR‑320b could markedly promote apoptosis by increasing the level of Bax and reducing Bcl-2 expression in glioma. Taken together, our data suggested that miR‑320b might serve as a novel prognostic marker and potential therapeutic target for glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Lv Q, Du H, Liu Y, Huang Y, Wang G, Zhang X, Chen S and Zhou H: Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. Oncol Rep 38: 959-966, 2017.
APA
Lv, Q., Du, H., Liu, Y., Huang, Y., Wang, G., Zhang, X. ... Zhou, H. (2017). Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. Oncology Reports, 38, 959-966. https://doi.org/10.3892/or.2017.5762
MLA
Lv, Q., Du, H., Liu, Y., Huang, Y., Wang, G., Zhang, X., Chen, S., Zhou, H."Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma". Oncology Reports 38.2 (2017): 959-966.
Chicago
Lv, Q., Du, H., Liu, Y., Huang, Y., Wang, G., Zhang, X., Chen, S., Zhou, H."Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma". Oncology Reports 38, no. 2 (2017): 959-966. https://doi.org/10.3892/or.2017.5762
Copy and paste a formatted citation
x
Spandidos Publications style
Lv Q, Du H, Liu Y, Huang Y, Wang G, Zhang X, Chen S and Zhou H: Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. Oncol Rep 38: 959-966, 2017.
APA
Lv, Q., Du, H., Liu, Y., Huang, Y., Wang, G., Zhang, X. ... Zhou, H. (2017). Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma. Oncology Reports, 38, 959-966. https://doi.org/10.3892/or.2017.5762
MLA
Lv, Q., Du, H., Liu, Y., Huang, Y., Wang, G., Zhang, X., Chen, S., Zhou, H."Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma". Oncology Reports 38.2 (2017): 959-966.
Chicago
Lv, Q., Du, H., Liu, Y., Huang, Y., Wang, G., Zhang, X., Chen, S., Zhou, H."Low expression of microRNA-320b correlates with tumorigenesis and unfavorable prognosis in glioma". Oncology Reports 38, no. 2 (2017): 959-966. https://doi.org/10.3892/or.2017.5762
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