Open Access

Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo

  • Authors:
    • Mahmoud Hashemzaei
    • Amin Delarami Far
    • Arezoo Yari
    • Reza Entezari Heravi
    • Kaveh Tabrizian
    • Seyed Mohammad Taghdisi
    • Sarvenaz Ekhtiari Sadegh
    • Konstantinos Tsarouhas
    • Dimitrios Kouretas
    • George Tzanakakis
    • Dragana Nikitovic
    • Nikita Yurevich Anisimov
    • Demetrios   A. Spandidos
    • Aristides M. Tsatsakis
    • Ramin Rezaee
  • View Affiliations

  • Published online on: June 28, 2017     https://doi.org/10.3892/or.2017.5766
  • Pages: 819-828
  • Copyright: © Hashemzaei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study focused on the elucidation of the putative anticancer potential of quercetin. The anticancer activity of quercetin at 10, 20, 40, 80 and 120 µM was assessed in vitro by MMT assay in 9 tumor cell lines (colon carcinoma CT‑26 cells, prostate adenocarcinoma LNCaP cells, human prostate PC3 cells, pheocromocytoma PC12 cells, estrogen receptor‑positive breast cancer MCF‑7 cells, acute lymphoblastic leukemia MOLT‑4 T‑cells, human myeloma U266B1 cells, human lymphoid Raji cells and ovarian cancer CHO cells). Quercetin was found to induce the apoptosis of all the tested cancer cell lines at the utilized concentrations. Moreover, quercetin significantly induced the apoptosis of the CT‑26, LNCaP, MOLT‑4 and Raji cell lines, as compared to control group (P<0.001), as demonstrated by Annexin V/PI staining. In in vivo experiments, mice bearing MCF‑7 and CT‑26 tumors exhibited a significant reduction in tumor volume in the quercetin‑treated group as compared to the control group (P<0.001). Taken together, quercetin, a naturally occurring compound, exhibits anticancer properties both in vivo and in vitro.
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August-2017
Volume 38 Issue 2

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Hashemzaei M, Delarami Far A, Yari A, Heravi RE, Tabrizian K, Taghdisi SM, Sadegh SE, Tsarouhas K, Kouretas D, Tzanakakis G, Tzanakakis G, et al: Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo. Oncol Rep 38: 819-828, 2017
APA
Hashemzaei, M., Delarami Far, A., Yari, A., Heravi, R.E., Tabrizian, K., Taghdisi, S.M. ... Rezaee, R. (2017). Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo. Oncology Reports, 38, 819-828. https://doi.org/10.3892/or.2017.5766
MLA
Hashemzaei, M., Delarami Far, A., Yari, A., Heravi, R. E., Tabrizian, K., Taghdisi, S. M., Sadegh, S. E., Tsarouhas, K., Kouretas, D., Tzanakakis, G., Nikitovic, D., Anisimov, N. Y., Spandidos, D. A., Tsatsakis, A. M., Rezaee, R."Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo". Oncology Reports 38.2 (2017): 819-828.
Chicago
Hashemzaei, M., Delarami Far, A., Yari, A., Heravi, R. E., Tabrizian, K., Taghdisi, S. M., Sadegh, S. E., Tsarouhas, K., Kouretas, D., Tzanakakis, G., Nikitovic, D., Anisimov, N. Y., Spandidos, D. A., Tsatsakis, A. M., Rezaee, R."Anticancer and apoptosis‑inducing effects of quercetin in vitro and in vivo". Oncology Reports 38, no. 2 (2017): 819-828. https://doi.org/10.3892/or.2017.5766