Anticancer potential of bioactive peptides from animal sources (Review)

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

McGuire S: World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr. 7:418–419. 2016. View Article : Google Scholar : PubMed/NCBI

Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R and Langer R: Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2:751–760. 2007. View Article : Google Scholar : PubMed/NCBI

Amit D and Hochberg A: Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences. J Transl Med. 8:1342010. View Article : Google Scholar : PubMed/NCBI

Kang TH, Mao CP, He L, Tsai YC, Liu K, La V, Wu TC and Hung CF: Tumor-targeted delivery of IL-2 by NKG2D leads to accumulation of antigen-specific CD8⁺ T cells in the tumor loci and enhanced anti-tumor effects. PLoS One. 7:e351412012. View Article : Google Scholar : PubMed/NCBI

Blaurock N, Schmerler D, Hünniger K, Kurzai O, Ludewig K, Baier M, Brunkhorst FM, Imhof D and Kiehntopf M: C-terminal alpha-1 antitrypsin peptide: A new sepsis biomarker with immunomodulatory function. Mediators Inflamm. 2016:61294372016. View Article : Google Scholar : PubMed/NCBI

Porta A, Petrone AM, Morello S, Granata I, Rizzo F, Memoli D, Weisz A and Maresca B: Design and expression of peptides with antimicrobial activity against Salmonella typhimurium. Cell Microbiol. 19:e126452017.doi: 10.1111/cmi.12645. View Article : Google Scholar

Dabarera MC, Athiththan LV and Perera RP: Antihypertensive peptides from curd. Ayu. 36:214–219. 2015. View Article : Google Scholar : PubMed/NCBI

Shiratsuchi E, Ura M, Nakaba M, Maeda I and Okamoto K: Elastin peptides prepared from piscine and mammalian elastic tissues inhibit collagen-induced platelet aggregation and stimulate migration and proliferation of human skin fibroblasts. J Pept Sci. 16:652–658. 2010. View Article : Google Scholar : PubMed/NCBI

Qin Y, Zhou J, Zhang W, Yang X, Wang J, Wei C, Gu F and Lei T: Construction of an anticancer fusion peptide (ACFP) derived from milk proteins and an assay of anti-ovarian cancer cells in vitro. Anticancer Agents Med Chem. Jun 26–2016.(Epub ahead of print).

Kongcharoen A, Poolex W, Wichai T and Boonsombat R: Production of an antioxidative peptide from hairy basil seed waste by a recombinant Escherichia coli. Biotechnol Lett. 38:1195–1201. 2016. View Article : Google Scholar : PubMed/NCBI

Iwaniak A, Darewicz M, Minkiewicz P, Protasiewicz M and Borawska J: (Biologically active peptides derived from food proteins as the food components with cardioprotective properties). Pol Merkur Lekarski. 36:403–406. 2014.(In Polish). PubMed/NCBI

Jang A, Jo C, Kang K-S and Lee M: Antimicrobial and human cancer cell cytotoxic effect of synthetic angiotensin-converting enzyme (ACE) inhibitory peptides. Food Chem. 107:327–336. 2008. View Article : Google Scholar

Su L, Xu G, Shen J, Tuo Y, Zhang X, Jia S, Chen Z and Su X: Anticancer bioactive peptide suppresses human gastric cancer growth through modulation of apoptosis and the cell cycle. Oncol Rep. 23:3–9. 2010.PubMed/NCBI

Yu L, Yang L, An W and Su X: Anticancer bioactive peptide-3 inhibits human gastric cancer growth by suppressing gastric cancer stem cells. J Cell Biochem. 115:697–711. 2014. View Article : Google Scholar : PubMed/NCBI

Su X, Dong C, Zhang J, Su L, Wang X, Cui H and Chen Z: Combination therapy of anti-cancer bioactive peptide with Cisplatin decreases chemotherapy dosing and toxicity to improve the quality of life in xenograft nude mice bearing human gastric cancer. Cell Biosci. 4:72014. View Article : Google Scholar : PubMed/NCBI

Su LY, Shi YX, Yan MR, Xi Y and Su XL: Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway. Acta Pharmacol Sin. 36:1514–1519. 2015. View Article : Google Scholar : PubMed/NCBI

Park YW and Nam MS: Bioactive peptides in milk and dairy products: A review. Korean J Food Sci Anim Resour. 35:831–840. 2015. View Article : Google Scholar : PubMed/NCBI

Roy MK, Watanabe Y and Tamai Y: Induction of apoptosis in HL-60 cells by skimmed milk digested with a proteolytic enzyme from the yeast Saccharomyces cerevisiae. J Biosci Bioeng. 88:426–432. 1999. View Article : Google Scholar : PubMed/NCBI

Meisel H and FitzGerald RJ: Biofunctional peptides from milk proteins: Mineral binding and cytomodulatory effects. Curr Pharm Des. 9:1289–1295. 2003. View Article : Google Scholar : PubMed/NCBI

MacDonald RS, Thornton WH Jr and Marshall RT: A cell culture model to identify biologically active peptides generated by bacterial hydrolysis of casein. J Dairy Sci. 77:1167–1175. 1994. View Article : Google Scholar : PubMed/NCBI

Ganjam LS, Thornton WH Jr, Marshall RT and MacDonald RS: Antiproliferative effects of yogurt fractions obtained by membrane dialysis on cultured mammalian intestinal cells. J Dairy Sci. 80:2325–2329. 1997. View Article : Google Scholar : PubMed/NCBI

Legrand D, Pierce A, Elass E, Carpentier M, Mariller C and Mazurier J: Lactoferrin structure and functions. Adv Exp Med Biol. 606:163–194. 2008. View Article : Google Scholar : PubMed/NCBI

Sánchez-Gómez S, Ferrer-Espada R, Stewart PS, Pitts B, Lohner K and de Martínez Tejada G: Antimicrobial activity of synthetic cationic peptides and lipopeptides derived from human lactoferricin against Pseudomonas aeruginosa planktonic cultures and biofilms. BMC Microbiol. 15:1372015. View Article : Google Scholar : PubMed/NCBI

Yin C, Wong JH and Ng TB: Recent studies on the antimicrobial peptides lactoferricin and lactoferrampin. Curr Mol Med. 14:1139–1154. 2014. View Article : Google Scholar : PubMed/NCBI

Mader JS, Salsman J, Conrad DM and Hoskin DW: Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines. Mol Cancer Ther. 4:612–624. 2005. View Article : Google Scholar : PubMed/NCBI

Eliassen LT, Berge G, Leknessund A, Wikman M, Lindin I, Løkke C, Ponthan F, Johnsen JI, Sveinbjørnsson B, Kogner P, et al: The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo. Int J Cancer. 119:493–500. 2006. View Article : Google Scholar : PubMed/NCBI

Yin CM, Wong JH, Xia J and Ng TB: Studies on anticancer activities of lactoferrin and lactoferricin. Curr Protein Pept Sci. 14:492–503. 2013. View Article : Google Scholar : PubMed/NCBI

Harnedy PA and FitzGerald RJ: Bioactive peptides from marine processing waste and shellfish: A review. J Funct Foods. 4:6–24. 2012. View Article : Google Scholar

Zhou QJ, Wang J, Liu M, Qiao Y, Hong WS, Su YQ, Han KH, Ke QZ and Zheng WQ: Identification, expression and antibacterial activities of an antimicrobial peptide NK-lysin from a marine fish Larimichthys crocea. Fish Shellfish Immunol. 55:195–202. 2016. View Article : Google Scholar : PubMed/NCBI

Shaala LA, Youssef DT, Ibrahim SR and Mohamed GA: Callyptide A, a new cytotoxic peptide from the Red Sea marine sponge Callyspongia species. Nat Prod Res. Mar 7–2016.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

Suarez-Jimenez GM, Burgos-Hernandez A and Ezquerra-Brauer JM: Bioactive peptides and depsipeptides with anticancer potential: Sources from marine animals. Mar Drugs. 10:963–986. 2012. View Article : Google Scholar : PubMed/NCBI

Guha P, Kaptan E, Bandyopadhyaya G, Kaczanowska S, Davila E, Thompson K, Martin SS, Kalvakolanu DV, Vasta GR and Ahmed H: Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis. Proc Natl Acad Sci USA. 110:5052–5057. 2013. View Article : Google Scholar : PubMed/NCBI

Jumeri and Kim SM: Antioxidant and anticancer activities of enzymatic hydrolysates of solitary tunicate (Styela clava). Food Sci Biotechnol. 20:10752011. View Article : Google Scholar

Kurt O, Ozdal-Kurt F, Tuğlu MI and Akçora CM: The cytotoxic, neurotoxic, apoptotic and antiproliferative activities of extracts of some marine algae on the MCF-7 cell line. Biotech Histochem. 89:568–576. 2014. View Article : Google Scholar : PubMed/NCBI

Hsu K-C, Li-Chan ECY and Jao C-L: Antiproliferative activity of peptides prepared from enzymatic hydrolysates of tuna dark muscle on human breast cancer cell line MCF-7. Food Chem. 126:617–622. 2011. View Article : Google Scholar

Lee YG, Kim JY, Lee KW, Kim KH and Lee HJ: Peptides from anchovy sauce induce apoptosis in a human lymphoma cell (U937) through the increase of caspase-3 and −8 activities. Ann NY Acad Sci. 1010:399–404. 2003. View Article : Google Scholar : PubMed/NCBI

Lee YG, Lee KW, Kim JY, Kim KH and Lee HJ: Induction of apoptosis in a human lymphoma cell line by hydrophobic peptide fraction separated from anchovy sauce. Biofactors. 21:63–67. 2004. View Article : Google Scholar : PubMed/NCBI

Picot L, Bordenave S, Didelot S, Fruitier-Arnaudin I, Sannier F, Thorkelsson G, Bergé JP, Guérard F, Chabeaud A and Piot JM: Antiproliferative activity of fish protein hydrolysates on human breast cancer cell lines. Process Biochem. 41:1217–1222. 2006. View Article : Google Scholar

Chen JY, Lin WJ and Lin TL: A fish antimicrobial peptide, tilapia hepcidin TH2-3, shows potent antitumor activity against human fibrosarcoma cells. Peptides. 30:1636–1642. 2009. View Article : Google Scholar : PubMed/NCBI

Chang WT, Pan CY, Rajanbabu V, Cheng CW and Chen JY: Tilapia (Oreochromis mossambicus) antimicrobial peptide, hepcidin 1–5, shows antitumor activity in cancer cells. Peptides. 32:342–352. 2011. View Article : Google Scholar : PubMed/NCBI

Chen JY, Lin WJ, Wu JL, Her GM and Hui CF: Epinecidin-1 peptide induces apoptosis which enhances antitumor effects in human leukemia U937 cells. Peptides. 30:2365–2373. 2009. View Article : Google Scholar : PubMed/NCBI

Hsu JC, Lin LC, Tzen JT and Chen JY: Characteristics of the antitumor activities in tumor cells and modulation of the inflammatory response in RAW264.7 cells of a novel antimicrobial peptide, chrysophsin-1, from the red sea bream (Chrysophrys major). Peptides. 32:900–910. 2011. View Article : Google Scholar : PubMed/NCBI

Wu SP, Huang TC, Lin CC, Hui CF, Lin CH and Chen JY: Pardaxin, a fish antimicrobial peptide, exhibits antitumor activity toward murine fibrosarcoma in vitro and in vivo. Mar Drugs. 10:1852–1872. 2012. View Article : Google Scholar : PubMed/NCBI

Wilson-Sanchez G, Moreno-Félix C, Velazquez C, Plascencia-Jatomea M, Acosta A, Machi-Lara L, Aldana-Madrid ML, Ezquerra-Brauer JM, Robles-Zepeda R and Burgos-Hernandez A: Antimutagenicity and antiproliferative studies of lipidic extracts from white shrimp (Litopenaeus vannamei). Mar Drugs. 8:2795–2809. 2010. View Article : Google Scholar : PubMed/NCBI

Lin MC, Lin SB, Chen JC, Hui CF and Chen JY: Shrimp anti-lipopolysaccharide factor peptide enhances the antitumor activity of cisplatin in vitro and inhibits HeLa cells growth in nude mice. Peptides. 31:1019–1025. 2010. View Article : Google Scholar : PubMed/NCBI

Somboonwiwat K, Marcos M, Tassanakajon A, Klinbunga S, Aumelas A, Romestand B, Gueguen Y, Boze H, Moulin G and Bachère E: Recombinant expression and anti-microbial activity of anti-lipopolysaccharide factor (ALF) from the black tiger shrimp Penaeus monodon. Dev Comp Immunol. 29:841–851. 2005. View Article : Google Scholar : PubMed/NCBI

Kannan A, Hettiarachchy NS, Marshall M, Raghavan S and Kristinsson H: Shrimp shell peptide hydrolysates inhibit human cancer cell proliferation. J Sci Food Agric. 91:1920–1924. 2011. View Article : Google Scholar : PubMed/NCBI

Aneiros A and Garateix A: Bioactive peptides from marine sources: Pharmacological properties and isolation procedures. J Chromatogr B Analyt Technol Biomed Life Sci. 803:41–53. 2004. View Article : Google Scholar : PubMed/NCBI

Baker MA, Grubb DR and Lawen A: Didemnin B induces apoptosis in proliferating but not resting peripheral blood mononuclear cells. Apoptosis. 7:407–412. 2002. View Article : Google Scholar : PubMed/NCBI

Ahuja D, Vera MD, SirDeshpande BV, Morimoto H, Williams PG, Joullié MM and Toogood PL: Inhibition of protein synthesis by didemnin B: How EF-1alpha mediates inhibition of translocation. Biochemistry. 39:4339–4346. 2000. View Article : Google Scholar : PubMed/NCBI

Vera MD and Joullié MM: Natural products as probes of cell biology: 20 years of didemnin research. Med Res Rev. 22:102–145. 2002. View Article : Google Scholar : PubMed/NCBI

Taraboletti G, Poli M, Dossi R, Manenti L, Borsotti P, Faircloth GT, Broggini M, D'Incalci M, Ribatti D and Giavazzi R: Antiangiogenic activity of aplidine, a new agent of marine origin. Br J Cancer. 90:2418–2424. 2004.PubMed/NCBI

Andavan GS and Lemmens-Gruber R: Cyclodepsipeptides from marine sponges: Natural agents for drug research. Mar Drugs. 8:810–834. 2010. View Article : Google Scholar : PubMed/NCBI

Faivre S, Chièze S, Delbaldo C, Ady-Vago N, Guzman C, Lopez-Lazaro L, Lozahic S, Jimeno J, Pico F, Armand JP, et al: Phase I and pharmacokinetic study of aplidine, a new marine cyclodepsipeptide in patients with advanced malignancies. J Clin Oncol. 23:7871–7880. 2005. View Article : Google Scholar : PubMed/NCBI

Geldof AA, Mastbergen SC, Henrar RE and Faircloth GT: Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays. Cancer Chemother Pharmacol. 44:312–318. 1999. View Article : Google Scholar : PubMed/NCBI

Albella B, Faircloth G, López-Lázaro L, Guzmán C, Jimeno J and Bueren JA: In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. comparison with the clinical results. Eur J Cancer. 38:1395–1404. 2002. View Article : Google Scholar : PubMed/NCBI

Hamada Y and Shioiri T: Recent progress of the synthetic studies of biologically active marine cyclic peptides and depsipeptides. Chem Rev. 105:4441–4482. 2005. View Article : Google Scholar : PubMed/NCBI

Vervoort H, Fenical W and Epifanio RA: Tamandarins A and B: New cytotoxic depsipeptides from a Brazilian ascidian of the family Didemnidae. J Org Chem. 65:782–792. 2000. View Article : Google Scholar : PubMed/NCBI

Cheng L, Wang C, Liu H, Wang F, Zheng L, Zhao J, Chu E and Lin X: A novel polypeptide extracted from Ciona savignyi induces apoptosis through a mitochondrial-mediated pathway in human colorectal carcinoma cells. Clin Colorectal Cancer. 11:207–214. 2012. View Article : Google Scholar : PubMed/NCBI

Liu G, Liu M, Wei J, Huang H, Zhang Y, Zhao J, Xiao L, Wu N, Zheng L and Lin X: CS5931, a novel polypeptide in Ciona savignyi, represses angiogenesis via inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). Mar Drugs. 12:1530–1544. 2014. View Article : Google Scholar : PubMed/NCBI

Blunt JW, Copp BR, Hu WP, Munro MH, Northcote PT and Prinsep MR: Marine natural products. Nat Prod Rep. 26:170–244. 2009. View Article : Google Scholar : PubMed/NCBI

Ibrahim SR, Min CC, Teuscher F, Ebel R, Kakoschke C, Lin W, Wray V, Edrada-Ebel R and Proksch P: Callyaerins A-F and H, new cytotoxic cyclic peptides from the Indonesian marine sponge Callyspongia aerizusa. Bioorg Med Chem. 18:4947–4956. 2010. View Article : Google Scholar : PubMed/NCBI

Coello L, Reyes F, Martín MJ, Cuevas C and Fernández R: Isolation and structures of pipecolidepsins A and B, cytotoxic cyclic depsipeptides from the Madagascan sponge Homophymia lamellosa. J Nat Prod. 77:298–303. 2014. View Article : Google Scholar : PubMed/NCBI

Zhan KX, Jiao WH, Yang F, Li J, Wang SP, Li YS, Han BN and Lin HW: Reniochalistatins A-E, cyclic peptides from the marine sponge Reniochalina stalagmitis. J Nat Prod. 77:2678–2684. 2014. View Article : Google Scholar : PubMed/NCBI

Williams DE, Yu K, Behrisch HW, Van Soest R and Andersen RJ: Rolloamides A and B, cytotoxic cyclic heptapeptides isolated from the Caribbean marine sponge Eurypon laughlini. J Nat Prod. 72:1253–1257. 2009. View Article : Google Scholar : PubMed/NCBI

Nakazawa H, Kitano K, Cioca D, Ishikawa M, Ueno M, Ishida F and Kiyosawa K: Induction of polyploidization by jaspamide in HL-60 cells. Acta Haematol. 104:65–71. 2000. View Article : Google Scholar : PubMed/NCBI

Cioca DP and Kitano K: Induction of apoptosis and CD10/neutral endopeptidase expression by jaspamide in HL-60 line cells. Cell Mol Life Sci. 59:1377–1387. 2002. View Article : Google Scholar : PubMed/NCBI

Odaka C, Sanders ML and Crews P: Jasplakinolide induces apoptosis in various transformed cell lines by a caspase-3-like protease-dependent pathway. Clin Diagn Lab Immunol. 7:947–952. 2000.PubMed/NCBI

Ebada SS, Wray V, de Voogd NJ, Deng Z, Lin W and Proksch P: Two new jaspamide derivatives from the marine sponge Jaspis splendens. Mar Drugs. 7:434–444. 2009. View Article : Google Scholar : PubMed/NCBI

Zampella A, Sepe V, Bellotta F, Luciano P, D'Auria MV, Cresteil T, Debitus C, Petek S, Poupat C and Ahond A: Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp. Org Biomol Chem. 7:4037–4044. 2009. View Article : Google Scholar : PubMed/NCBI

Pelay-Gimeno M, García-Ramos Y, Martin Jesús M, Spengler J, Molina-Guijarro JM, Munt S, Francesch AM, Cuevas C, Tulla-Puche J and Albericio F: The first total synthesis of the cyclodepsipeptide pipecolidepsin A. Nat Commun. 4:23522013. View Article : Google Scholar : PubMed/NCBI

Freitas VM, Rangel M, Bisson LF, Jaeger RG and Machado-Santelli GM: The geodiamolide H, derived from Brazilian sponge Geodia corticostylifera, regulates actin cytoskeleton, migration and invasion of breast cancer cells cultured in three-dimensional environment. J Cell Physiol. 216:583–594. 2008. View Article : Google Scholar : PubMed/NCBI

Tan KC, Wakimoto T and Abe I: Lipodiscamides A-C, new cytotoxic lipopeptides from Discodermia kiiensis. Org Lett. 16:3256–3259. 2014. View Article : Google Scholar : PubMed/NCBI

Bishara A, Rudi A, Aknin M, Neumann D, Ben-Califa N and Kashman Y: Taumycins A and B, two bioactive lipodepsipeptides from the Madagascar sponge Fascaplysinopsis sp. Org Lett. 10:4307–4309. 2008. View Article : Google Scholar : PubMed/NCBI

Teta R, Irollo E, Della Sala G, Pirozzi G, Mangoni A and Costantino V: Smenamides A and B, chlorinated peptide/polyketide hybrids containing a dolapyrrolidinone unit from the Caribbean sponge Smenospongia aurea. Evaluation of their role as leads in antitumor drug research. Mar Drugs. 11:4451–4463. 2013. View Article : Google Scholar : PubMed/NCBI

Wang YK, He HL, Wang GF, Wu H, Zhou BC, Chen XL and Zhang YZ: Oyster (Crassostrea gigas) hydrolysates produced on a plant scale have antitumor activity and immunostimulating effects in BALB/c mice. Mar Drugs. 8:255–268. 2010. View Article : Google Scholar : PubMed/NCBI

Cheong SH, Kim EK, Hwang JW, Kim YS, Lee JS, Moon SH, Jeon BT and Park PJ: Purification of a novel peptide derived from a shellfish, Crassostrea gigas, and evaluation of its anticancer property. J Agric Food Chem. 61:11442–11446. 2013. View Article : Google Scholar : PubMed/NCBI

Kim EK, Joung HJ, Kim YS, Hwang JW, Ahn CB, Jeon YJ, Moon SH and Park PJ: Purification of a novel anticancer peptide from enzymatic hydrolysate of Mytilus coruscus. J Microbiol Biotechnol. 22:1381–1387. 2012. View Article : Google Scholar : PubMed/NCBI

Harris JR and Markl J: Keyhole limpet hemocyanin: Molecular structure of a potent marine immunoactivator. A review. Eur Urol. 37:(Suppl 3). 24–33. 2000. View Article : Google Scholar : PubMed/NCBI

Tzianabos AO: Polysaccharide immunomodulators as therapeutic agents: Structural aspects and biologic function. Clin Microbiol Rev. 13:523–533. 2000. View Article : Google Scholar : PubMed/NCBI

Lamm DL, Dehaven JI and Riggs DR: Keyhole limpet hemocyanin immunotherapy of bladder cancer: Laboratory and clinical studies. Eur Urol. 37:(Suppl 3). 41–44. 2000. View Article : Google Scholar : PubMed/NCBI

Murai A, Kitahara K, Okumura S, Kobayashi M and Horio F: Oral antibiotics enhance antibody responses to keyhole limpet hemocyanin in orally but not muscularly immunized chickens. Anim Sci J. 87:257–265. 2016. View Article : Google Scholar : PubMed/NCBI

Riggs DR, Jackson B, Vona-Davis L and McFadden D: In vitro anticancer effects of a novel immunostimulant: Keyhole limpet hemocyanin. J Surg Res. 108:279–284. 2002. View Article : Google Scholar : PubMed/NCBI

McFadden DW, Riggs DR, Jackson BJ and Vona-Davis L: Keyhole limpet hemocyanin, a novel immune stimulant with promising anticancer activity in Barrett's esophageal adenocarcinoma. Am J Surg. 186:552–555. 2003. View Article : Google Scholar : PubMed/NCBI

Riggs DR, Jackson BJ, Vona-Davis L, Nigam A and McFadden DW: In vitro effects of keyhole limpet hemocyanin in breast and pancreatic cancer in regards to cell growth, cytokine production, and apoptosis. Am J Surg. 189:680–684. 2005. View Article : Google Scholar : PubMed/NCBI

Pettit GR, Srirangam JK, Barkoczy J, Williams MD, Durkin KP, Boyd MR, Bai R, Hamel E, Schmidt JM and Chapuis JC: Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications. Anticancer Drug Des. 10:529–544. 1995.PubMed/NCBI

Pettit GR, Flahive EJ, Boyd MR, Bai R, Hamel E, Pettit RK and Schmidt JM: Antineoplastic agents 360. Synthesis and cancer cell growth inhibitory studies of dolastatin 15 structural modifications. Anticancer Drug Des. 13:47–66. 1998.PubMed/NCBI

Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, et al: Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications. J Med Chem. 57:10527–10543. 2014. View Article : Google Scholar : PubMed/NCBI

Gajula PK, Asthana J, Panda D and Chakraborty TK: A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death. J Med Chem. 56:2235–2245. 2013. View Article : Google Scholar : PubMed/NCBI

Pettit GR, Hogan F and Toms S: Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10. J Nat Prod. 74:962–968. 2011. View Article : Google Scholar : PubMed/NCBI

Suenaga K, Kajiwara S, Kuribayashi S, Handa T and Kigoshi H: Synthesis and cytotoxicity of aurilide analogs. Bioorg Med Chem Lett. 18:3902–3905. 2008. View Article : Google Scholar : PubMed/NCBI

Sato S, Murata A, Orihara T, Shirakawa T, Suenaga K, Kigoshi H and Uesugi M: Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol. 18:131–139. 2011. View Article : Google Scholar : PubMed/NCBI

Semenzato M, Cogliati S and Scorrano L: Prohibitin(g) cancer: Aurilide and killing by Opa1-dependent cristae remodeling. Chem Biol. 18:8–9. 2011. View Article : Google Scholar : PubMed/NCBI

Shilabin AG and Hamann MT: In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities. Bioorg Med Chem. 19:6628–6632. 2011. View Article : Google Scholar : PubMed/NCBI

Cruz LJ, Luque-Ortega JR, Rivas L and Albericio F: Kahalalide F, an antitumor depsipeptide in clinical trials, and its analogues as effective antileishmanial agents. Mol Pharm. 6:813–824. 2009. View Article : Google Scholar : PubMed/NCBI

Hosta L, Pla-Roca M, Arbiol J, López-Iglesias C, Samitier J, Cruz LJ, Kogan MJ and Albericio F: Conjugation of Kahalalide F with gold nanoparticles to enhance in vitro antitumoral activity. Bioconjug Chem. 20:138–146. 2009. View Article : Google Scholar : PubMed/NCBI

García-Rocha M, Bonay P and Avila J: The antitumoral compound Kahalalide F acts on cell lysosomes. Cancer Lett. 99:43–50. 1996. View Article : Google Scholar : PubMed/NCBI

Janmaat ML, Rodriguez JA, Jimeno J, Kruyt FA and Giaccone G: Kahalalide F induces necrosis-like cell death that involves depletion of ErbB3 and inhibition of Akt signaling. Mol Pharmacol. 68:502–510. 2005.PubMed/NCBI

Wesson KJ and Hamann MT: Keenamide A, a bioactive cyclic peptide from the marine mollusk Pleurobranchus forskalii. J Nat Prod. 59:629–631. 1996. View Article : Google Scholar : PubMed/NCBI

Conlon JM, Mechkarska M, Lukic ML and Flatt PR: Potential therapeutic applications of multifunctional host-defense peptides from frog skin as anti-cancer, anti-viral, immunomodulatory, and anti-diabetic agents. Peptides. 57:67–77. 2014. View Article : Google Scholar : PubMed/NCBI

Angeletti LR, Agrimi U, Curia C, French D and Mariani-Costantini R: Healing rituals and sacred serpents. Lancet. 340:223–225. 1992. View Article : Google Scholar : PubMed/NCBI

Oelkrug C, Hartke M and Schubert A: Mode of action of anticancer peptides (ACPs) from amphibian origin. Anticancer Res. 35:635–643. 2015.PubMed/NCBI

Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H and Woodhams DC: The alyteserins: Two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). Peptides. 30:1069–1073. 2009. View Article : Google Scholar : PubMed/NCBI

Conlon JM, Mechkarska M, Prajeep M, Arafat K, Zaric M, Lukic ML and Attoub S: Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent. Amino Acids. 44:715–723. 2013. View Article : Google Scholar : PubMed/NCBI

Conlon JM, Galadari S, Raza H and Condamine E: Design of potent, non-toxic antimicrobial agents based upon the naturally occurring frog skin peptides, ascaphin-8 and peptide XT-7. Chem Biol Drug Des. 72:58–64. 2008. View Article : Google Scholar : PubMed/NCBI

Rozek T, Wegener KL, Bowie JH, Olver IN, Carver JA, Wallace JC and Tyler MJ: The antibiotic and anticancer active aurein peptides from the Australian bell frogs Litoria aurea and Litoria raniformis the solution structure of aurein 1.2. Eur J Biochem. 267:5330–5341. 2000. View Article : Google Scholar : PubMed/NCBI

van Zoggel H, Hamma-Kourbali Y, Galanth C, Ladram A, Nicolas P, Courty J, Amiche M and Delbé J: Antitumor and angiostatic peptides from frog skin secretions. Amino Acids. 42:385–395. 2012. View Article : Google Scholar : PubMed/NCBI

Shi D, Hou X, Wang L, Gao Y, Wu D, Xi X, Zhou M, Kwok HF, Duan J, Chen T, et al: Two novel dermaseptin-like antimicrobial peptides with anticancer activities from the skin secretion of Pachymedusa dacnicolor. Toxins (Basel). 8:82016. View Article : Google Scholar

Conlon JM, Woodhams DC, Raza H, Coquet L, Leprince J, Jouenne T, Vaudry H and Rollins-Smith LA: Peptides with differential cytolytic activity from skin secretions of the lemur leaf frog Hylomantis lemur (Hylidae: Phyllomedusinae). Toxicon. 50:498–506. 2007. View Article : Google Scholar : PubMed/NCBI

Wan Y, Ma C, Zhou M, Xi X, Li L, Wu D, Wang L, Lin C, Lopez JC, Chen T, et al: Phylloseptin-PBa - A novel broad-spectrum antimicrobial peptide from the skin secretion of the peruvian purple-sided leaf frog (Phyllomedusa baltea) which exhibits cancer cell cytotoxicity. Toxins (Basel). 7:5182–5193. 2015. View Article : Google Scholar : PubMed/NCBI

Ohsaki Y, Gazdar AF, Chen HC and Johnson BE: Antitumor activity of magainin analogues against human lung cancer cell lines. Cancer Res. 52:3534–3538. 1992.PubMed/NCBI

Lehmann J, Retz M, Sidhu SS, Suttmann H, Sell M, Paulsen F, Harder J, Unteregger G and Stöckle M: Antitumor activity of the antimicrobial peptide magainin II against bladder cancer cell lines. Eur Urol. 50:141–147. 2006. View Article : Google Scholar : PubMed/NCBI

Baker MA, Maloy WL, Zasloff M and Jacob LS: Anticancer efficacy of Magainin2 and analogue peptides. Cancer Res. 53:3052–3057. 1993.PubMed/NCBI

Koszałka P, Kamysz E, Wejda M, Kamysz W and Bigda J: Antitumor activity of antimicrobial peptides against U937 histiocytic cell line. Acta Biochim Pol. 58:111–117. 2011.PubMed/NCBI

Miyazaki Y, Aoki M, Yano Y and Matsuzaki K: Interaction of antimicrobial peptide magainin 2 with gangliosides as a target for human cell binding. Biochemistry. 51:10229–10235. 2012. View Article : Google Scholar : PubMed/NCBI

Li S, Hao L, Bao W, Zhang P, Su D, Cheng Y, Nie L, Wang G, Hou F and Yang Y: A novel short anionic antibacterial peptide isolated from the skin of Xenopus laevis with broad antibacterial activity and inhibitory activity against breast cancer cell. Arch Microbiol. 198:473–482. 2016. View Article : Google Scholar : PubMed/NCBI

Libério MS, Joanitti GA, Azevedo RB, Cilli EM, Zanotta LC, Nascimento AC, Sousa MV, Pires Júnior OR, Fontes W and Castro MS: Anti-proliferative and cytotoxic activity of pentadactylin isolated from Leptodactylus labyrinthicus on melanoma cells. Amino Acids. 40:51–59. 2011. View Article : Google Scholar : PubMed/NCBI

Attoub S, Arafat H, Mechkarska M and Conlon JM: Anti-tumor activities of the host-defense peptide hymenochirin-1B. Regul Pept. 187:51–56. 2013. View Article : Google Scholar : PubMed/NCBI

Attoub S, Mechkarska M, Sonnevend A, Radosavljevic G, Jovanovic I, Lukic ML and Conlon JM: Esculentin-2CHa: A host-defense peptide with differential cytotoxicity against bacteria, erythrocytes and tumor cells. Peptides. 39:95–102. 2013. View Article : Google Scholar : PubMed/NCBI

Merchant ME, Roche C, Elsey RM and Prudhomme J: Antibacterial properties of serum from the American alligator (Alligator mississippiensis). Comp Biochem Physiol B Biochem Mol Biol. 136:505–513. 2003. View Article : Google Scholar : PubMed/NCBI

Merchant ME, Pallansch M, Paulman RL, Wells JB, Nalca A and Ptak R: Antiviral activity of serum from the American alligator (Alligator mississippiensis). Antiviral Res. 66:35–38. 2005. View Article : Google Scholar : PubMed/NCBI

Merchant ME, Leger N, Jerkins E, Mills K, Pallansch MB, Paulman RL and Ptak RG: Broad spectrum antimicrobial activity of leukocyte extracts from the American alligator (Alligator mississippiensis). Vet Immunol Immunopathol. 110:221–228. 2006. View Article : Google Scholar : PubMed/NCBI

Merchant ME, Roche CM, Thibodeaux D and Elsey RM: Identification of alternative pathway serum complement activity in the blood of the American alligator (Alligator mississippiensis). Comp Biochem Physiol B Biochem Mol Biol. 141:281–288. 2005. View Article : Google Scholar : PubMed/NCBI

Pata S, Yaraksa N, Daduang S, Temsiripong Y, Svasti J, Araki T and Thammasirirak S: Characterization of the novel antibacterial peptide Leucrocin from crocodile (Crocodylus siamensis) white blood cell extracts. Dev Comp Immunol. 35:545–553. 2011. View Article : Google Scholar : PubMed/NCBI

Yaraksa N, Anunthawan T, Theansungnoen T, Daduang S, Araki T, Dhiravisit A and Thammasirirak S: Design and synthesis of cationic antibacterial peptide based on Leucrocin I sequence, antibacterial peptide from crocodile (Crocodylus siamensis) white blood cell extracts. J Antibiot (Tokyo). 67:205–212. 2014. View Article : Google Scholar : PubMed/NCBI

Patathananone S, Thammasirirak S, Daduang J, Chung JG, Temsiripong Y and Daduang S: Bioactive compounds from crocodile (Crocodylus siamensis) white blood cells induced apoptotic cell death in hela cells. Environ Toxicol. 31:986–997. 2016. View Article : Google Scholar : PubMed/NCBI

Theansungnoen T, Maijaroen S, Jangpromma N, Yaraksa N, Daduang S, Temsiripong T, Daduang J and Klaynongsruang S: Cationic antimicrobial peptides derived from Crocodylus siamensis leukocyte extract, revealing anticancer activity and apoptotic induction on human cervical cancer cells. Protein J. 35:202–211. 2016. View Article : Google Scholar : PubMed/NCBI

He S, Mao X, Zhang T, Guo X, Ge Y, Ma C and Zhang X: Separation and nanoencapsulation of antitumor peptides from Chinese three-striped box turtle (Cuora trifasciata). J Microencapsul. 33:344–354. 2016. View Article : Google Scholar : PubMed/NCBI

Chippaux JP and Goyffon M: Epidemiology of scorpionism: A global appraisal. Acta Trop. 107:71–79. 2008. View Article : Google Scholar : PubMed/NCBI

Goudet C, Chi CW and Tytgat J: An overview of toxins and genes from the venom of the Asian scorpion Buthus martensi Karsch. Toxicon. 40:1239–1258. 2002. View Article : Google Scholar : PubMed/NCBI

Srinivasan KN, Gopalakrishnakone P, Tan PT, Chew KC, Cheng B, Kini RM, Koh JL, Seah SH and Brusic V: SCORPION, a molecular database of scorpion toxins. Toxicon. 40:23–31. 2002. View Article : Google Scholar : PubMed/NCBI

DeBin JA, Maggio JE and Strichartz GR: Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol. 264:C361–C369. 1993.PubMed/NCBI

Dardevet L, Rani D, Aziz TA, Bazin I, Sabatier JM, Fadl M, Brambilla E and De Waard M: Chlorotoxin: A helpful natural scorpion peptide to diagnose glioma and fight tumor invasion. Toxins (Basel). 7:1079–1101. 2015. View Article : Google Scholar : PubMed/NCBI

Mamelak AN and Jacoby DB: Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601). Expert Opin Drug Deliv. 4:175–186. 2007. View Article : Google Scholar : PubMed/NCBI

Veiseh O, Gunn JW, Kievit FM, Sun C, Fang C, Lee JS and Zhang M: Inhibition of tumor-cell invasion with chlorotoxin-bound superparamagnetic nanoparticles. Small. 5:256–264. 2009. View Article : Google Scholar : PubMed/NCBI

Deshane J, Garner CC and Sontheimer H: Chlorotoxin inhibits glioma cell invasion via matrix metalloproteinase-2. J Biol Chem. 278:4135–4144. 2003. View Article : Google Scholar : PubMed/NCBI

Soroceanu L, Manning TJ Jr and Sontheimer H: Modulation of glioma cell migration and invasion using Cl(−) and K(+) ion channel blockers. J Neurosci. 19:5942–5954. 1999.PubMed/NCBI

Sontheimer H: An unexpected role for ion channels in brain tumor metastasis. Exp Biol Med (Maywood). 233:779–791. 2008. View Article : Google Scholar : PubMed/NCBI

Lui VC, Lung SS, Pu JK, Hung KN and Leung GK: Invasion of human glioma cells is regulated by multiple chloride channels including ClC-3. Anticancer Res. 30:4515–4524. 2010.PubMed/NCBI

Guo X, Ma C, Du Q, Wei R, Wang L, Zhou M, Chen T and Shaw C: Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: Evaluation of their antimicrobial and anticancer activities. Biochimie. 95:1784–1794. 2013. View Article : Google Scholar : PubMed/NCBI

Ali SA, Alam M, Abbasi A, Undheim EA, Fry BG, Kalbacher H and Voelter W: Structure-activity relationship of chlorotoxin-like peptides. Toxins (Basel). 8:362016. View Article : Google Scholar : PubMed/NCBI

Kuhn-Nentwig L: Antimicrobial and cytolytic peptides of venomous arthropods. Cell Mol Life Sci. 60:2651–2668. 2003. View Article : Google Scholar : PubMed/NCBI

Vorontsova OV, Egorova NS, Arseniev AS and Feofanov AV: Haemolytic and cytotoxic action of latarcin Ltc2a. Biochimie. 93:227–241. 2011. View Article : Google Scholar : PubMed/NCBI

Liu Z, Deng M, Xiang J, Ma H, Hu W, Zhao Y, Li DW and Liang S: A novel spider peptide toxin suppresses tumor growth through dual signaling pathways. Curr Mol Med. 12:1350–1360. 2012. View Article : Google Scholar : PubMed/NCBI

Moreno M and Giralt E: Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparan. Toxins (Basel). 7:1126–1150. 2015. View Article : Google Scholar : PubMed/NCBI

Havas LJ: Effect of bee venom on colchicine-induced tumours. Nature. 166:567–568. 1950. View Article : Google Scholar : PubMed/NCBI

Jo M, Park MH, Kollipara PS, An BJ, Song HS, Han SB, Kim JH, Song MJ and Hong JT: Anti-cancer effect of bee venom toxin and melittin in ovarian cancer cells through induction of death receptors and inhibition of JAK2/STAT3 pathway. Toxicol Appl Pharmacol. 258:72–81. 2012. View Article : Google Scholar : PubMed/NCBI

Wang C, Chen T, Zhang N, Yang M, Li B, Lü X, Cao X and Ling C: Melittin, a major component of bee venom, sensitizes human hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating CaMKII-TAK1-JNK/p38 and inhibiting IkappaBalpha kinase-NFkappaB. J Biol Chem. 284:3804–3813. 2009. View Article : Google Scholar : PubMed/NCBI

Park MH, Choi MS, Kwak DH, Oh KW, Yoon DY, Han SB, Song HS, Song MJ and Hong JT: Anti-cancer effect of bee venom in prostate cancer cells through activation of caspase pathway via inactivation of NF-κB. Prostate. 71:801–812. 2011. View Article : Google Scholar : PubMed/NCBI

Park JH, Jeong YJ, Park KK, Cho HJ, Chung IK, Min KS, Kim M, Lee KG, Yeo JH, Park KK, et al: Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression. Mol Cells. 29:209–215. 2010. View Article : Google Scholar : PubMed/NCBI

Gajski G and Garaj-Vrhovac V: Melittin: A lytic peptide with anticancer properties. Environ Toxicol Pharmacol. 36:697–705. 2013. View Article : Google Scholar : PubMed/NCBI

Pan H, Soman NR, Schlesinger PH, Lanza GM and Wickline SA: Cytolytic peptide nanoparticles (‘NanoBees’) for cancer therapy. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 3:318–327. 2011. View Article : Google Scholar : PubMed/NCBI

Soman NR, Baldwin SL, Hu G, Marsh JN, Lanza GM, Heuser JE, Arbeit JM, Wickline SA and Schlesinger PH: Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth. J Clin Invest. 119:2830–2842. 2009. View Article : Google Scholar : PubMed/NCBI

Yamada Y, Shinohara Y, Kakudo T, Chaki S, Futaki S, Kamiya H and Harashima H: Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy. Int J Pharm. 303:1–7. 2005. View Article : Google Scholar : PubMed/NCBI

de Azevedo RA, Figueiredo CR, Ferreira AK, Matsuo AL, Massaoka MH, Girola N, Auada AV, Farias CF, Pasqualoto KF, Rodrigues CP, et al: Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo. Peptides. 68:113–119. 2015. View Article : Google Scholar : PubMed/NCBI

Vyas VK, Brahmbhatt K, Bhatt H and Parmar U: Therapeutic potential of snake venom in cancer therapy: Current perspectives. Asian Pac J Trop Biomed. 3:156–162. 2013. View Article : Google Scholar : PubMed/NCBI

Kerkis I, Hayashi MA, da Prieto Silva AR, Pereira A, De Sá, Júnior PL, Zaharenko AJ, Rádis-Baptista G, Kerkis A and Yamane T: State of the art in the studies on crotamine, a cell penetrating peptide from South American rattlesnake. Biomed Res Int. 2014:6759852014. View Article : Google Scholar : PubMed/NCBI

Pereira A, Kerkis A, Hayashi MA, Pereira AS, Silva FS, Oliveira EB, da Prieto Silva AR, Yamane T, Rádis-Baptista G and Kerkis I: Crotamine toxicity and efficacy in mouse models of melanoma. Expert Opin Investig Drugs. 20:1189–1200. 2011. View Article : Google Scholar : PubMed/NCBI

León G, Sánchez L, Hernández A, Villalta M, Herrera M, Segura A, Estrada R and Gutiérrez JM: Immune response towards snake venoms. Inflamm Allergy Drug Targets. 10:381–398. 2011. View Article : Google Scholar : PubMed/NCBI

Wang H, Ke M, Tian Y, Wang J, Li B, Wang Y, Dou J and Zhou C: BF-30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice. Eur J Pharmacol. 707:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

Naumann GB, Silva LF, Silva L, Faria G, Richardson M, Evangelista K, Kohlhoff M, Gontijo CM, Navdaev A, de Rezende FF, et al: Cytotoxicity and inhibition of platelet aggregation caused by an l-amino acid oxidase from Bothrops leucurus venom. Biochim Biophys Acta. 1810:683–694. 2011. View Article : Google Scholar : PubMed/NCBI

Harris F, Dennison SR, Singh J and Phoenix DA: On the selectivity and efficacy of defense peptides with respect to cancer cells. Med Res Rev. 33:190–234. 2013. View Article : Google Scholar : PubMed/NCBI

Lohner K and Hilpert K: Antimicrobial peptides: Cell membrane and microbial surface interactions. Biochim Biophys Acta. 1858:915–917. 2016. View Article : Google Scholar : PubMed/NCBI

Bailly C: Anticancer properties of lamellarins. Mar Drugs. 13:1105–1123. 2015. View Article : Google Scholar : PubMed/NCBI

Riedl S, Leber R, Rinner B, Schaider H, Lohner K and Zweytick D: Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. Biochim Biophys Acta. 1848:2918–2931. 2015. View Article : Google Scholar : PubMed/NCBI

Riedl S, Rinner B, Asslaber M, Schaider H, Walzer S, Novak A, Lohner K and Zweytick D: In search of a novel target - phosphatidylserine exposed by non-apoptotic tumor cells and metastases of malignancies with poor treatment efficacy. Biochim Biophys Acta. 1808:2638–2645. 2011. View Article : Google Scholar : PubMed/NCBI

Papo N, Seger D, Makovitzki A, Kalchenko V, Eshhar Z, Degani H and Shai Y: Inhibition of tumor growth and elimination of multiple metastases in human prostate and breast xenografts by systemic inoculation of a host defense-like lytic peptide. Cancer Res. 66:5371–5378. 2006. View Article : Google Scholar : PubMed/NCBI

Won A, Ruscito A and Ianoul A: Imaging the membrane lytic activity of bioactive peptide latarcin 2a. Biochim Biophys Acta. 1818:3072–3080. 2012. View Article : Google Scholar : PubMed/NCBI

Rashid R, Veleba M and Kline KA: Focal targeting of the bacterial envelope by antimicrobial peptides. Front Cell Dev Biol. 4:552016. View Article : Google Scholar : PubMed/NCBI

Sorochkina AI, Kovalchuk SI, Omarova EO, Sobko AA, Kotova EA and Antonenko YN: Peptide-induced membrane leakage by lysine derivatives of gramicidin A in liposomes, planar bilayers, and erythrocytes. Biochim Biophys Acta. 1828:2428–2435. 2013. View Article : Google Scholar : PubMed/NCBI

Ryan L, Lamarre B, Diu T, Ravi J, Judge PJ, Temple A, Carr M, Cerasoli E, Su B, Jenkinson HF, et al: Anti-antimicrobial peptides: Folding-mediated host defense antagonists. J Biol Chem. 288:20162–20172. 2013. View Article : Google Scholar : PubMed/NCBI

Han Y, Cui Z, Li YH, Hsu WH and Lee BH: In vitro and in vivo anticancer activity of pardaxin against proliferation and growth of oral squamous cell carcinoma. Mar Drugs. 14:22015. View Article : Google Scholar : PubMed/NCBI

Pino-Angeles A, Leveritt JM III and Lazaridis T: Pore structure and synergy in antimicrobial peptides of the magainin family. PLOS Comput Biol. 12:e10045702016. View Article : Google Scholar : PubMed/NCBI

Zhang SK, Song JW, Gong F, Li SB, Chang HY, Xie HM, Gao HW, Tan YX and Ji SP: Design of an α-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci Rep. 6:273942016. View Article : Google Scholar : PubMed/NCBI

Kashiwada A, Mizuno M and Hashimoto J: pH-Dependent membrane lysis by using melittin-inspired designed peptides. Org Biomol Chem. 14:6281–6288. 2016. View Article : Google Scholar : PubMed/NCBI

Ros U and García-Sáez AJ: More Than a Pore: The interplay of pore-forming proteins and lipid membranes. J Membr Biol. 248:545–561. 2015. View Article : Google Scholar : PubMed/NCBI

Bolintineanu DS, Vivcharuk V and Kaznessis YN: Multiscale models of the antimicrobial peptide protegrin-1 on gram-negative bacteria membranes. Int J Mol Sci. 13:11000–11011. 2012. View Article : Google Scholar : PubMed/NCBI

Lohner K: Novel antibiotics based upon the multiple mechanisms of membrane perturbation by antimicrobial peptides. Curr Top Med Chem. July;2016.(In press). PubMed/NCBI

Wang C, Zolotarskaya OY, Nair SS, Ehrhardt CJ, Ohman DE, Wynne KJ and Yadavalli VK: Real-time observation of antimicrobial polycation effects on Escherichia coli: Adapting the carpet model for membrane disruption to quaternary copolyoxetanes. Langmuir. 32:2975–2984. 2016. View Article : Google Scholar : PubMed/NCBI

Bechinger B: The SMART model: Soft membranes adapt and respond, also transiently, in the presence of antimicrobial peptides. J Pept Sci. 21:346–355. 2015. View Article : Google Scholar : PubMed/NCBI

Mulder KC, Lima LA, Miranda VJ, Dias SC and Franco OL: Current scenario of peptide-based drugs: The key roles of cationic antitumor and antiviral peptides. Front Microbiol. 4:3212013. View Article : Google Scholar : PubMed/NCBI

Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, et al: Bax regulates primary necrosis through mitochondrial dynamics. Proc Natl Acad Sci USA. 109:6566–6571. 2012. View Article : Google Scholar : PubMed/NCBI

Linkermann A, Konstantinidis K and Kitsis RN: Catch me if you can: Targeting the mitochondrial permeability transition pore in myocardial infarction. Cell Death Differ. 23:1–2. 2016. View Article : Google Scholar : PubMed/NCBI

Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, et al: Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. eLife. 2:e007722013. View Article : Google Scholar : PubMed/NCBI

Farsinejad S, Gheisary Z, Samani Ebrahimi S and Alizadeh AM: Mitochondrial targeted peptides for cancer therapy. Tumour Biol. 36:5715–5725. 2015. View Article : Google Scholar : PubMed/NCBI

Meng MX, Ning JF, Yu JY, Chen DD, Meng XL, Xu JP and Zhang J: Antitumor activity of recombinant antimicrobial peptide penaeidin-2 against kidney cancer cells. J Huazhong Univ Sci Technolog Med Sci. 34:529–534. 2014. View Article : Google Scholar : PubMed/NCBI

Hilchie AL, Doucette CD, Pinto DM, Patrzykat A, Douglas S and Hoskin DW: Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts. Breast Cancer Res. 13:R1022011. View Article : Google Scholar : PubMed/NCBI

Hilchie AL, Conrad DM, Coombs MR, Zemlak T, Doucette CD, Liwski RS and Hoskin DW: Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts. Leuk Lymphoma. 54:2255–2262. 2013. View Article : Google Scholar : PubMed/NCBI

Eike LM, Yang N, Rekdal Ø and Sveinbjørnsson B: The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells. Oncotarget. 6:34910–34923. 2015.PubMed/NCBI

Burns KE, McCleerey TP and Thévenin D: pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates. Sci Rep. 6:284652016. View Article : Google Scholar : PubMed/NCBI

Mandal SM, Pati BR, Chakraborty R and Franco OL: New insights into the bioactivity of peptides from probiotics. Front Biosci (Elite Ed). 8:450–459. 2016. View Article : Google Scholar : PubMed/NCBI

Gaspar D, Veiga AS and Castanho MA: From antimicrobial to anticancer peptides. A review. Front Microbiol. 4:2942013. View Article : Google Scholar : PubMed/NCBI

Liao W, Zhang R, Dong C, Yu Z and Ren J: Novel walnut peptide-selenium hybrids with enhanced anticancer synergism: Facile synthesis and mechanistic investigation of anticancer activity. Int J Nanomed. 11:1305–1321. 2016.

Svensen N, Walton JG and Bradley M: Peptides for cell-selective drug delivery. Trends Pharmacol Sci. 33:186–192. 2012. View Article : Google Scholar : PubMed/NCBI

Wakabayashi N, Yano Y, Kawano K and Matsuzaki K: A pH-dependent charge reversal peptide for cancer targeting. Eur Biophys J. 46:121–127. 2017. View Article : Google Scholar : PubMed/NCBI

Hu X and Liu S: Recent advances towards the fabrication and biomedical applications of responsive polymeric assemblies and nanoparticle hybrid superstructures. Dalton Trans. 44:3904–3922. 2015. View Article : Google Scholar : PubMed/NCBI

Balducci A, Wen Y, Zhang Y, Helfer BM, Hitchens TK, Meng WS, Wesa AK and Janjic JM: A novel probe for the non-invasive detection of tumor-associated inflammation. OncoImmunology. 2:e230342013. View Article : Google Scholar : PubMed/NCBI