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Article

Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma

  • Authors:
    • Mingming Fan
    • Jun Shen
    • Hu Liu
    • Zhijian Wen
    • Jue Yang
    • Pinghua Yang
    • Kai Liu
    • Yanxin Chang
    • Jicheng Duan
    • Kai Lu
  • View Affiliations / Copyright

    Affiliations: Department of Laparoscopy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China, The First Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, P.R. China, Department of Hepatobiliary Pancreatic Vascular Surgery, No. 174 Hospital of PLA, Xiamen, Fujian, P.R. China
  • Pages: 1083-1090
    |
    Published online on: July 3, 2017
       https://doi.org/10.3892/or.2017.5785
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Abstract

Paired-related homeobox 1 (PRRX1) has been identified as a novel molecule associated with induction of epithelial-mesenchymal transition (EMT), acquisition of cancer stem cell like properties and poor prognosis in tumors. However, the function of PRRX1 in hepatocellular carcinoma has not been elucidated. In the present study, we observed that PRRX1 expression levels were downregulated and positively correlated with the downregulated expression of p53 in hepatocellular carcinoma specimens. Decreased expression of PRRX1 and/or p53 by siRNA induced both the migration and the invasion features of HCC cells in vitro. Furthermore, the loss of PRRX1 inhibits hepatocellular carcinoma (HCC) cell apoptosis, an anti-apoptotic expression profile was upregulated accompanied by downregulated expression of p53. HCC patients with low-expression of both PRRX1 and p53 had a significantly shorter overall and disease-free survival. These findings demonstrate that PRRX1 plays an important role in metastasis and apoptosis of HCC cells through the p53-dependent signaling pathway and is expected to become a novel biomarker associated with patient prognosis and survival.
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1 

Bosch FX, Ribes J, Díaz M and Cléries R: Primary liver cancer: Worldwide incidence and trends. Gastroenterology. 127:(Suppl 1). S5–S16. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Yuen MF, Tanaka Y, Fong DY, Fung J, Wong DK, Yuen JC, But DY, Chan AO, Wong BC, Mizokami M, et al: Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B. J Hepatol. 50:80–88. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Tsai JH, Donaher JL, Murphy DA, Chau S and Yang J: Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell. 22:725–736. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Tsai JH and Yang J: Epithelial-mesenchymal plasticity in carcinoma metastasis. Genes Dev. 27:2192–2206. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Bae YK, Choi JE, Kang SH and Lee SJ: Epithelial-mesenchymal transition phenotype is associated with clinicopathological factors that indicate aggressive biological behavior and poor clinical outcomes in invasive breast cancer. J Breast Cancer. 18:256–263. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Polyak K and Weinberg RA: Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat Rev Cancer. 9:265–273. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Taneyhill LA, Coles EG and Bronner-Fraser M: Snail2 directly represses cadherin 6B during epithelial-to-mesenchymal transitions of the neural crest. Development. 134:1481–1490. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Deep G, Jain AK, Ramteke A, Ting H, Vijendra KC, Gangar SC, Agarwal C and Agarwal R: SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin. Mol Cancer. 13:372014. View Article : Google Scholar : PubMed/NCBI

9 

Campbell K, Whissell G, Franch-Marro X, Batlle E and Casanova J: Specific GATA factors act as conserved inducers of an endodermal-EMT. Dev Cell. 21:1051–1061. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Song K, Li Q, Jiang ZZ, Guo CW and Li P: Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer. Cancer Biol Ther. 12:388–398. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Ocaña OH, Córcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, Barrallo-Gimeno A, Cano A and Nieto MA: Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell. 22:709–724. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Takahashi Y, Sawada G, Kurashige J, Uchi R, Matsumura T, Ueo H, Takano Y, Akiyoshi S, Eguchi H, Sudo T, et al: Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer. Br J Cancer. 109:307–311. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Guo J, Fu Z, Wei J, Lu W, Feng J and Zhang S: PRRX1 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer. Med Oncol. 32:3932015. View Article : Google Scholar : PubMed/NCBI

14 

Hirata H, Sugimachi K, Takahashi Y, Ueda M, Sakimura S, Uchi R, Kurashige J, Takano Y, Nanbara S, Komatsu H, et al: Downregulation of PRRX1 confers cancer stem cell-like properties and predicts poor prognosis in hepatocellular carcinoma. Ann Surg Oncol. 22:(Suppl 3). S1402–S1409. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Vogelstein B, Lane D and Levine AJ: Surfing the p53 network. Nature. 408:307–310. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Chari NS, Pinaire NL, Thorpe L, Medeiros LJ, Routbort MJ and McDonnell TJ: The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death. Apoptosis. 14:336–347. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Soussi T: p53 alterations in human cancer: More questions than answers. Oncogene. 26:2145–2156. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Lewis BC, Klimstra DS, Socci ND, Xu S, Koutcher JA and Varmus HE: The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol Cell Biol. 25:1228–1237. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Chen YW, Klimstra DS, Mongeau ME, Tatem JL, Boyartchuk V and Lewis BC: Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res. 67:7589–7596. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Hansen JE, Fischer LK, Chan G, Chang SS, Baldwin SW, Aragon RJ, Carter JJ, Lilly M, Nishimura RN, Weisbart RH, et al: Antibody-mediated p53 protein therapy prevents liver metastasis in vivo. Cancer Res. 67:1769–1774. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Marte B: Cancer: Super p53. Nature. 420:2792002. View Article : Google Scholar : PubMed/NCBI

22 

Yee SB, Choi HJ, Chung SW, Park DH, Sung B, Chung HY and Kim ND: Growth inhibition of luteolin on HepG2 cells is induced via p53 and Fas/Fas-ligand besides the TGF-β pathway. Int J Oncol. 47:747–754. 2015.PubMed/NCBI

23 

Zhu R, Mok MT, Kang W, Lau SS, Yip WK, Chen Y, Lai PB, Wong VW, To KF, Sung JJ, et al: Truncated HBx-dependent silencing of GAS2 promotes hepatocarcinogenesis through deregulation of cell cycle, senescence and p53-mediated apoptosis. J Pathol. 237:38–49. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Lou G, Liu Y, Wu S, Xue J, Yang F, Fu H, Zheng M and Chen Z: The p53/miR-34a/SIRT1 positive feedback loop in quercetin-induced apoptosis. Cell Physiol Biochem. 35:2192–2202. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fan M, Shen J, Liu H, Wen Z, Yang J, Yang P, Liu K, Chang Y, Duan J, Lu K, Lu K, et al: Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma. Oncol Rep 38: 1083-1090, 2017.
APA
Fan, M., Shen, J., Liu, H., Wen, Z., Yang, J., Yang, P. ... Lu, K. (2017). Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma. Oncology Reports, 38, 1083-1090. https://doi.org/10.3892/or.2017.5785
MLA
Fan, M., Shen, J., Liu, H., Wen, Z., Yang, J., Yang, P., Liu, K., Chang, Y., Duan, J., Lu, K."Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 38.2 (2017): 1083-1090.
Chicago
Fan, M., Shen, J., Liu, H., Wen, Z., Yang, J., Yang, P., Liu, K., Chang, Y., Duan, J., Lu, K."Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 38, no. 2 (2017): 1083-1090. https://doi.org/10.3892/or.2017.5785
Copy and paste a formatted citation
x
Spandidos Publications style
Fan M, Shen J, Liu H, Wen Z, Yang J, Yang P, Liu K, Chang Y, Duan J, Lu K, Lu K, et al: Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma. Oncol Rep 38: 1083-1090, 2017.
APA
Fan, M., Shen, J., Liu, H., Wen, Z., Yang, J., Yang, P. ... Lu, K. (2017). Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma. Oncology Reports, 38, 1083-1090. https://doi.org/10.3892/or.2017.5785
MLA
Fan, M., Shen, J., Liu, H., Wen, Z., Yang, J., Yang, P., Liu, K., Chang, Y., Duan, J., Lu, K."Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 38.2 (2017): 1083-1090.
Chicago
Fan, M., Shen, J., Liu, H., Wen, Z., Yang, J., Yang, P., Liu, K., Chang, Y., Duan, J., Lu, K."Downregulation of PRRX1 via the p53-dependent signaling pathway predicts poor prognosis in hepatocellular carcinoma". Oncology Reports 38, no. 2 (2017): 1083-1090. https://doi.org/10.3892/or.2017.5785
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